(5 references)-
- 抗原 See all TNFRSF18 抗体
- TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
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适用
- 小鼠
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宿主
- 大鼠
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克隆类型
- 单克隆
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标记
- This TNFRSF18 antibody is un-conjugated
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应用范围
- Flow Cytometry (FACS), Blocking Reagent (BR)
- 品牌
- BD Pharmingen™
- 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 过滤
- 0.2 μm filtered
- 内毒素水平
- Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
- 免疫原
- Mouse CD25+ CD4+ T Cell Line
- 克隆位点
- DTA
- 亚型
- IgG2b
- Top Product
- Discover our top product TNFRSF18 Primary Antibody
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anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-162) antibody
TNFRSF18 适用: 人 FACS, ELISA, WB, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 2A7A6 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 266-162) antibodyTNFRSF18 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM78 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 201-274) antibodyTNFRSF18 适用: 人 ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 184-241) antibodyTNFRSF18 适用: 人 FACS, ELISA, WB, IHC, ICC, Neut 宿主: 小鼠 Monoclonal 6H8B9 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 90-162) antibodyTNFRSF18 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 1-241) antibodyTNFRSF18 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-115) antibodyTNFRSF18 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 2H4 unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (C-Term) antibodyTNFRSF18 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 50-177) antibodyTNFRSF18 适用: 人 FACS, ELISA 宿主: 兔 Monoclonal DM52 unconjugated Recombinant Antibody
anti-Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18) (AA 26-115) antibodyTNFRSF18 适用: 人, 小鼠 ELISA, WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2H4 unconjugated
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- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1.0 mg/mL
- 缓冲液
- No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
- 储存液
- Azide free
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
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: "Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells." in: The Journal of experimental medicine, Vol. 202, Issue 7, pp. 885-91, (2005) (PubMed).
: "Cutting edge: the natural ligand for glucocorticoid-induced TNF receptor-related protein abrogates regulatory T cell suppression." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 172, Issue 10, pp. 5823-7, (2004) (PubMed).
: "Mouse glucocorticoid-induced tumor necrosis factor receptor ligand is costimulatory for T cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 25, pp. 15059-64, (2003) (PubMed).
: "Stimulation of CD25(+)CD4(+) regulatory T cells through GITR breaks immunological self-tolerance." in: Nature immunology, Vol. 3, Issue 2, pp. 135-42, (2002) (PubMed).
: "A new member of the tumor necrosis factor/nerve growth factor receptor family inhibits T cell receptor-induced apoptosis." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 12, pp. 6216-21, (1997) (PubMed).
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: "Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells." in: The Journal of experimental medicine, Vol. 202, Issue 7, pp. 885-91, (2005) (PubMed).
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- 抗原
- TNFRSF18 (Tumor Necrosis Factor Receptor Superfamily, Member 18 (TNFRSF18))
- 别名
- GITR (TNFRSF18 产品)
- 别名
- GITR antibody, TNFRSF18 antibody, AITR antibody, Gitr antibody, CD357 antibody, GITR-D antibody, TNF receptor superfamily member 18 antibody, tumor necrosis factor receptor superfamily, member 18 antibody, TNFRSF18 antibody, Tnfrsf18 antibody
- 背景
- The DTA-1 antibody reacts with GITR [Glucocorticoid-induced Tumor necrosis factor (TNF) receptor family-Related], a 66-70-kDa homodimer glycoprotein that is a member of the TNF receptor superfamily and is also known as TNFRSF18. As its name implies, GITR expression was first detected in T lymphocytes that had been treated with dexamethasone, a glucocorticoid. In normal naive mice, GITR is expressed at moderate levels on CD25-positive/CD4-positive/CD8a-negative thymocytes and on CD25-positive/CD4-positive/CD45RB-low splenocytes. It is also expressed at low levels on splenic CD25-negative/CD4-positive/CD45RB-low T lymphocytes, B lymphocytes, macrophages, and dendritic cells. Activation of T and B lymphocytes upregulates GITR expression. GITR is a costimulatory receptor that plays an important role in Regulatory T (Treg)-cell functions, and a GITR Ligand has been detected on B lymphocytes, macrophages, and dendritic cells. mAb DTA-1 abrogates suppression by Treg cells without affecting their proliferative response, while it is co-stimulatory for T lymphocytes that are not Treg cells.
- 途径
- Cancer Immune Checkpoints
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