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MUC1 抗体

MUC1 适用: 人 IHC (fro), EIA 宿主: 小鼠 Monoclonal VU-12E1 unconjugated
产品编号 ABIN1106101
发货至: 中国
  • 抗原 See all MUC1 抗体
    MUC1 (Mucin 1 (MUC1))
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    小鼠
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    单克隆
    标记
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    This MUC1 antibody is un-conjugated
    应用范围
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    Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    特异性
    VU-12E1 reacts with MUC1.
    交叉反应 (详细)
    Species reactivity (tested):Human.
    纯化方法
    Purified
    免疫原
    A Balb/c mouse was immunized with live cells (10e7 cells/dose in PBS) of human breast cancer cell line ZR-75-1. Splenocytes were fused with SP2/0 mouse myeloma cells. Stability of the hybridomas was established by subcloning four times.
    克隆位点
    VU-12E1
    亚型
    IgG1
    Top Product
    Discover our top product MUC1 Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 浓度
    0,1 mg/mL
    缓冲液
    PBS, 0.05 % sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Avoid repeated freezing and thawing.
    储存条件
    4 °C/-20 °C
    储存方法
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原
    MUC1 (Mucin 1 (MUC1))
    别名
    CD227 / Mucin-1 / MUC1 (MUC1 产品)
    别名
    CA 15-3 antibody, CD227 antibody, EMA antibody, H23AG antibody, KL-6 antibody, MAM6 antibody, MCKD1 antibody, MUC-1 antibody, MUC-1/SEC antibody, MUC-1/X antibody, MUC1/ZD antibody, PEM antibody, PEMT antibody, PUM antibody, Muc-1 antibody, mucin 1, cell surface associated antibody, mucin 1, transmembrane antibody, MUC1 antibody, Muc1 antibody
    背景
    MUC1 is a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 aminoacids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is upregulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion. The dominant epitope of mAb VU12E1 is the 5-mer PDTRP of the MUC1 tandem repeat as established with Synonyms: Breast carcinoma-associated antigen DF3, CA 15-3, Carcinoma-associated mucin, DF3, EMA, Episialin, H23AG, MUC-1, PEMT, PUM, Peanut-reactive urinary mucin, Polymorphic epithelial mucin, Tumor-associated epithelial membrane antigen, Tumor-associated mucin
    基因ID
    4582
    NCBI登录号
    NP_001018016
    UniProt
    P15941
    途径
    Negative Regulation of intrinsic apoptotic Signaling
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