-
- 抗原 See all CD130/gp130 (IL6ST) 抗体
- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
-
适用
- 人, 小鼠
-
宿主
-
仓鼠
-
克隆类型
- 单克隆
-
标记
- This CD130/gp130 antibody is un-conjugated
-
应用范围
- Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
- 交叉反应 （详细）
- Species reactivity (tested):Human, mouse
- 纯化方法
- Protein G agarose
- 免疫原
- Mouse CD130 transfected 293T cells
- 克隆位点
- HMb1
- 亚型
- IgG
- Top Product
- Discover our top product IL6ST Primary Antibody
-
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 392-566) antibody
IL6ST 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 238-500) antibodyIL6ST 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 73-231) antibodyIL6ST 适用: 人, 猴 WB, IHC, ELISA, FACS, ICC, Neut 宿主: 小鼠 Monoclonal 8D4D2 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 26-323) antibodyIL6ST 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 871-899), (C-Term) antibodyIL6ST 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB17993 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 651-750) antibodyIL6ST 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (pSer782) antibodyIL6ST 适用: 人, 大鼠 WB, ELISA, IF (p), ICC, IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (AA 678-857) antibodyKO Validated IL6ST 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibodyIL6ST 适用: 人 WB, IHC, ELISA, FACS, IP, Func 宿主: 小鼠 Monoclonal B-P4 unconjugated
anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) (C-Term) antibodyIL6ST 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
- Optimal working dilution should be determined by the investigator.
- 限制
- 仅限研究用
-
- 浓度
- 1.0 mg/mL
- 缓冲液
- PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
- 储存液
- Without preservative
- 注意事项
- Avoid repeated freezing and thawing.
- 储存条件
- -20 °C
- 储存方法
- Store (in aliquots) at -20 °C.
-
- 抗原
- CD130/gp130 (IL6ST) (Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
- 别名
- CD130 / IL6ST (IL6ST 产品)
- 别名
- CD130 antibody, CDW130 antibody, GP130 antibody, IL-6RB antibody, 5133400A03Rik antibody, AA389424 antibody, BB405851 antibody, D13Ertd699e antibody, gp130 antibody, Ac1055 antibody, Gp130 antibody, Il-6rb antibody, IL-6 antibody, interleukin 6 signal transducer antibody, IL6ST antibody, Il6st antibody, il6st antibody
- 背景
- The interleukin-6 (IL-6) cytokine family, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and B-cell stimulatory factor 3, are also known as gp130 cytokines because they all share gp130 as a common transducer protein within their functional receptor complexes. In the case of IL-6, binding of the ligand to its specific a-receptor (IL-6Ra/CD126) induces dimerization of gp130, activation of the gp130-associated Janus kinases Jak1, Jak2 and Tyk2 and phosphorylation of gp130 at cytoplasmic tyrosine residues. These phosphotyrosines serve as docking sites for SH2-domain-containing proteins such as STAT1, STAT3, the protein tyrosine phosphatase SHP2 and the suppressor of cytokine signaling 3 (SOCS3). The subsequently tyrosine phosphorylated STAT homo- or heterodimers translocate to the nucleus where they bind to enhancer sequences of IL-6-inducible genes. Both IL-6Ra and gp130 have soluble forms. Although soluble gp130 inhibits the effect of IL-6, the soluble IL-6Ra promotes the effect of IL-6.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
- 基因ID
- 10090
- UniProt
- Q00560
- 途径
- JAK/STAT Signaling, Cellular Glucan Metabolic Process, Autophagy, Smooth Muscle Cell Migration, Cancer Immune Checkpoints
-
You are here:
