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抗Human LRRC32 抗体:
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Human Monoclonal LRRC32 Primary Antibody for ELISA, IP - ABIN4230471
Tran, Shevach: Therapeutic potential of FOXP3(+) regulatory T cells and their interactions with dendritic cells. in Human immunology 2009
Show all 3 Pubmed References
Human Polyclonal LRRC32 Primary Antibody for FACS, WB - ABIN4331580
Macaulay, Thon, Tijssen, Steele, MacDonald, Meade, Burns, Rendon, Salunkhe, Murphy, Bennett, Watkins, He, Fitzgerald, Italiano, Maguire: Canonical Wnt signaling in megakaryocytes regulates proplatelet formation. in Blood 2013
Human Monoclonal LRRC32 Primary Antibody for WB - ABIN1981876
Wang, Zhu, Dong, Shi, Lu, Springer: GARP regulates the bioavailability and activation of TGF?. in Molecular biology of the cell 2012
GARP (显示 CNGB1 抗体) is a surface molecule of regulatory T cells with roles in the regulatory function and TGF-beta (显示 TGFB1 抗体) releasing [review]
Data show that the Treg activation marker GARP (glycoprotein A repetitions predominant) is expressed on primary melanoma.
High GARP (显示 CNGB1 抗体) expression is associated with pancreatic cancer and liver metastases from colorectal cancer.
study showed that stimulated, human B lymphocytes produce active TGF-beta1 (显示 TGFB1 抗体) from surface GARP (显示 CNGB1 抗体)/latent TGF-beta1 (显示 TGFB1 抗体) complexes with isotype switching to IgA (显示 IgA 抗体) production.
GARP (显示 CNGB1 抗体) plays an important role in the pathogenesis of atopic dermatitis.
CD4 (显示 CD4 抗体)(+) CD25 (显示 IL2RA 抗体)(+) GARP (显示 CNGB1 抗体)(+) Treg cells are defective in dilated cardiomyopathy patients and GARP (显示 CNGB1 抗体) seems to be a better molecular definition of the regulatory phenotype.
these results define the oncogenic effects of the GARP (显示 CNGB1 抗体)-TGFbeta (显示 TGFB1 抗体) axis in the tumor microenvironment
LRRC32 expression is significantly upregulated in human masticatory mucosa during wound healing
GARP (显示 CNGB1 抗体) deficiency leads to accumulation of sphingolipid synthesis intermediates, changes in sterol distribution, and lysosomal dysfunction.
since GARP (显示 CNGB1 抗体) functions as a transporter of transforming growth factor beta (TGFbeta (显示 TGFB1 抗体)), a cytokine with broad pleiotropic traits, GARP (显示 CNGB1 抗体) transcriptional attenuation by alternative promoters might provide a mechanism regulating peripheral TGFb (显示 TGFB1 抗体)
Data (including data from studies using knockout mice) suggest that Garp/Lrrc32 is involved in up-regulation of Tgfb3 (显示 TGFB3 抗体) and is essential for normal embryogenesis of palate; knockout of Garp causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 (显示 SMAD2 抗体) phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Tgfb3 (显示 TGFB3 抗体) = transforming growth factor beta 3 (显示 TGFB3 抗体); Smad2 (显示 SMAD2 抗体) = MAD homolog protein 2)
These results demonstrate the unexpected presence of GARP on Hepatic stellate cells and its significance in regard to the ability of Hepatic stellate cells to activate latent TGF-beta1 (显示 TGFB1 抗体) and thereby inhibit T cells.
GARP expression on MSCs contributed to their ability to inhibit T-cell responses in vitro.
We conclude that a missense mutation in VPS54 (显示 VPS54 抗体), an essential component of the Golgi-associated retrograde protein complex, not only prevents the formation of an acrosome but also initiates a cascade of metabolic abnormalities and a stress reaction.
These findings suggest a role for GARP in natural and induced Treg development through activation of bound latent TGF-beta (显示 TGFB1 抗体) and signaling, which negatively regulates GARP expression on Tregs.
GARP is a regulatory T cell specific cell surface molecule that mediates suppressive signals and induces Foxp3 (显示 FOXP3 抗体) expression
This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies.
leucine rich repeat containing 32
, leucine-rich repeat-containing protein 32
, leucine-rich repeat-containing protein 32-like
, glycoprotein A repetitions predominant