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The protein encoded by UPK1A is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. 再加上，我们可以发UPK1A 蛋白 (6) 和 和数多这个蛋白质的别的产品。
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Human Polyclonal UPK1A Primary Antibody for EIA, WB - ABIN955479
Wang, Min, Glockshuber, Sun, Kong: Uropathogenic E. coli adhesin-induced host cell receptor conformational changes: implications in transmembrane signaling transduction. in Journal of molecular biology 2009
Show all 3 Pubmed References
Down-regulation of UPK1A suppresses proliferation and enhances apoptosis of bladder transitional cell carcinoma cells.
expression of UPKIa was a promising predictor for poor outcome of colorectal cancer patients
Reduced expression of uroplakin 1A is associated with gastric adenocarcinoma.
Loss of UPK1A is associated with esophageal squamous cell carcinoma.
uroplakin Ia is expressed in urinary bladder transitional cell carcinoma
determined the genomic structure of the uroplakin Ia gene and defined the position of a transcriptional start site
The authors show by cryo-electron microscopy that FimH binding to the extracellular domain of UP Ia induces global conformational changes in the entire UP receptor complex, including a coordinated movement of the tightly bundled transmembrane helices.
mouse urothelium responds to the adhesion of type 1-fimbriated UPEC by activating dual ligand/receptor system, one between FimH adhesin and uroplakin Ia and another between lipopolysaccharide and Tlr4.
These data support a model in which SNX31 mediates the endocytic degradation of uroplakins.
The despites a lower level of expression, UPIa maintain its plaque association in urothelial preneoplastic lesions.
structure of the major membrane protein complex from urinary bladder epithelial cells by cryo-electron crystallography
Localization of uroplakin Ia, the urothelial receptor for bacterial adhesin FimH, on the six inner domains of the 16 nm urothelial plaque particle
analysis of glycan structures of uroplakins Ia and Ib
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions.
, uroplakin 1A
, uroplakin Ia
, uroplakin IA