蛋白简介

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with USP2

• ubiquitin specific peptidase 2 (USP2) 抗体
• ubiquitin specific peptidase 2 (Usp2) 抗体
• ubiquitin specific peptidase 2a (usp2a) 抗体

• B930035K21Rik 抗体
• UBP-t 抗体
• Ubp41 抗体
• UBP46 抗体
• ubp52 抗体
• 显示所有的同义词和别名
• ubp66 抗体
• USP9 抗体
• zgc:92134 抗体

Protein level used designations for USP2

41 kDa ubiquitin-specific protease , deubiquitinating enzyme 2 , ubiquitin carboxyl-terminal hydrolase 2 , ubiquitin specific protease 12 , ubiquitin specific protease 9 , ubiquitin thioesterase 2 , ubiquitin-specific-processing protease 2 , ubiquitin specific protease 2 , ubiquitin thiolesterase 2 , ubiquitin-specific-processing protease testis , family of cysteine protease , ubiquitin specific protease 41 , ubiquitin specific protease 46 , ubiquitin specific protease 52 , ubiquitin specific protease 66