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USP2 产品

(Ubiquitin Specific Peptidase 2 (USP2))

Categories

This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011].

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Featured USP2 Categories

USP2 抗体

High quality antibodies with extensive validation data.

USP2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended USP2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC (p)
Validations
  • (12)
  • (4)
Cat. No. ABIN388879
Quantity 400 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, IHC (p)
Validations
  • (4)
  • (4)
Cat. No. ABIN388877
Quantity 400 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC
Validations
  • (2)
Cat. No. ABIN7174279
Quantity 100 μL
Datasheet Datasheet

Recommended USP2 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6232795
Quantity 96 tests
Datasheet Datasheet

Recommended USP2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7420525
Quantity 100 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7420528
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
Cat. No. ABIN3096154
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our USP2 Products

Kitamura, Ishino, Shimamoto, Okabe, Miyamoto, Takahashi, Miyoshi: "Ubiquitin-Specific Protease 2 Modulates the Lipopolysaccharide-Elicited Expression of Proinflammatory Cytokines in Macrophage-like HL-60 Cells." in: Mediators of inflammation, Vol. 2017, pp. 6909415, (2018) (PubMed).

Ren, Zhao, Liu, Yuan, Cheng, Zuo, Qian, Liu, Guo, Zhang, Wang, Qian, Li, Ge, Dai, Xiong, Zheng: "Deubiquitinase USP2a Sustains Interferons Antiviral Activity by Restricting Ubiquitination of Activated STAT1 in the Nucleus." in: PLoS pathogens, Vol. 12, Issue 7, pp. e1005764, (2017) (PubMed).

Davis, Pragani, Fox, Shen, Parmar, Gaudiano, Liu, Tanega, McGee, Hall, McKnight, Shinn, Nelson, Chattopadhyay, DAndrea, Auld, DeLucas, Li, Boxer, Simeonov: "Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models." in: The Journal of biological chemistry, Vol. 291, Issue 47, pp. 24628-24640, (2017) (PubMed).

Boustani, Khoshnood, Nikpasand, Taleshi, Ahmadi, Yahaghi, Goudarzi: "Overexpression of ubiquitin-specific protease 2a (USP2a) and nuclear factor erythroid 2-related factor 2 (Nrf2) in human gliomas." in: Journal of the neurological sciences, Vol. 363, pp. 249-52, (2016) (PubMed).

Zhang, Zhao, Zhang, Zhao, Gao: "Ubiquitin-specific protease 2b negatively regulates IFN-? production and antiviral activity by targeting TANK-binding kinase 1." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 193, Issue 5, pp. 2230-7, (2014) (PubMed).

Kitamura, Kimura, Shimamoto, Okabe, Ito, Miyamoto, Naoe, Kikuguchi, Meek, Toda, Okamoto, Kanehira, Hase, Watarai, Ishizuka, El-Osta, Ohara, Miyoshi: "Ubiquitin-specific protease 2-69 in macrophages potentially modulates metainflammation." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 27, Issue 12, pp. 4940-53, (2013) (PubMed).

Tong, Buelow, Guha, Rausch, Yin: "USP2a protein deubiquitinates and stabilizes the circadian protein CRY1 in response to inflammatory signals." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25280-91, (2012) (PubMed).

Alonso, Magyar, Wang, Bisello, Friedman: "Ubiquitination-deubiquitination balance dictates ligand-stimulated PTHR sorting." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 26, Issue 12, pp. 2923-34, (2011) (PubMed).

Bedard, Yang, Gregory, Cyr, Suzuki, Yu, Chian, Hermo, OFlaherty, Smith, Clarke, Wing: "Mice lacking the USP2 deubiquitinating enzyme have severe male subfertility associated with defects in fertilization and sperm motility." in: Biology of reproduction, Vol. 85, Issue 3, pp. 594-604, (2011) (PubMed).

Oberfeld, Ruffieux-Daidié, Vitagliano, Pos, Verrey, Staub: "Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC)-ubiquitylating enzyme Nedd4-2." in: American journal of physiology. Renal physiology, Vol. 301, Issue 1, pp. F189-96, (2011) (PubMed).

Synonyms and alternative names related to USP2

ubiquitin specific peptidase 2 (USP2), ubiquitin specific peptidase 2 (Usp2), ubiquitin specific peptidase 2a (usp2a), B930035K21Rik, UBP-t, UBP41, Ubp41, UBP46, ubp52, ubp66, USP9, zgc:92134

Protein level used designations for USP2

  • 41 kDa ubiquitin-specific protease
  • deubiquitinating enzyme 2
  • ubiquitin carboxyl-terminal hydrolase 2
  • ubiquitin specific protease 12
  • ubiquitin specific protease 9
  • ubiquitin thioesterase 2
  • ubiquitin-specific-processing protease 2
  • ubiquitin specific protease 2
  • ubiquitin thiolesterase 2
  • ubiquitin-specific-processing protease testis
  • family of cysteine protease
  • ubiquitin specific protease 41
  • ubiquitin specific protease 46
  • ubiquitin specific protease 52
  • ubiquitin specific protease 66
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