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TFCP2 encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. 再加上，我们可以发Transcription Factor CP2 蛋白 (8) 和 Transcription Factor CP2 试剂盒 (7)和数多这个蛋白质的别的产品。
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Dog (Canine) Monoclonal TFCP2 Primary Antibody for IF, WB - ABIN968193
Shirra, Zhu, Huang, Pallas, Hansen: One exon of the human LSF gene includes conserved regions involved in novel DNA-binding and dimerization motifs. in Molecular and cellular biology 1994
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High expression of CP2c was significantly correlated with patient age, and higher histological grade, stage, and small and large vessel invasion in HCC (显示 FAM126A 抗体) tissues.
FQI1 mediates alteration of the tumor epigenome by DNMT1 (显示 DNMT1 抗体)-LSF complex disruption, leading to aberrant DNA methylation (显示 HELLS 抗体) and gene expression.
The results suggest potential roles of LSF (TFCP2 ) as a growth regulator through control of the transcription of p21CIP1 (显示 CDKN1A 抗体) in melanocytes and melanoma cells as well as a biomarker for nevus.
Complement proteins C7 and CFH (显示 CFH 抗体) control the stemness of liver cancer cells via LSF-1 pathway.
LSF is an important mediator in colorectal carcinoma tumorigenesis and progression, and LSF expression is an important index for and prognostic prediction.
Antiproliferative small-molecule inhibitors of transcription factor LSF reveal oncogene (显示 RAB1A 抗体) addiction to LSF in hepatocellular carcinoma
Secreted OPN (显示 SPP1 抗体), induced by LSF, activates c-Met via a potential interaction between OPN (显示 SPP1 抗体) and its cell surface receptor CD44 (显示 CD44 抗体). A significant correlation was observed among LSF, OPN (显示 SPP1 抗体), and activated c-Met levels in HCC (显示 FAM126A 抗体).
Inhibition of MMP-9 (显示 MMP9 抗体) significantly abrogated LSF-induced angiogenesis as well as in vivo tumorigenesis, thus reinforcing the role of MMP-9 (显示 MMP9 抗体) in facilitating LSF function.
Data suggest that LSF is a key mediator of the Notch1 (显示 NOTCH1 抗体) signaling pathway, suggesting that it might be a novel therapeutic target for the treatment of hepatocellular carcinoma.
Study show that CRTR-1 (显示 TFCP2L1 抗体) is generally an activator of transcription (显示 STAT1 抗体) and that it modulates the activity of other family members, CP2 (显示 CP 抗体), NF2d9 (显示 UBP1 抗体) and altNF2d9, in a cell specific manner.
The transcription factor CP2 upregulated miR (显示 MLXIP 抗体)-144 expression, which partially contributed to the suppression of COX-2 (显示 COX2 抗体) in mGCs.
that yin yang 1 (显示 YY1 抗体) strongly localizes in the spermatogonial stem cells and co-localizes heterogeneously with CP2c to permit spermatogenesis
present study shows that a transcription factor previously unrelated with epithelial-mesenchymal transition (EMT (显示 ITK 抗体)), TFCP2c/LSF/LBP-1c, was translocated to the nucleus and bound to the fibronectin (显示 FN1 抗体) promoter upon EMT (显示 ITK 抗体) induction by Snail1 (显示 SNAI1 抗体)
the binding of Pin1 (显示 PIN1 抗体) at the Thr (显示 TRH 抗体)-329-Pro-330 motif in LSF permits isomerization by Pin1 (显示 PIN1 抗体) of the peptide bonds at the nearby phosphorylated SP motifs (Ser (显示 SIGLEC1 抗体)-291 and Ser (显示 SIGLEC1 抗体)-309) to the trans configuration, thereby facilitating their dephosphorylation.
CP2 contributes to the pathogenesis of Alzheimer's disease by inducing transferrin (显示 Tf 抗体) expression via up-regulating its transcription.
CP2 is a major factor in the regulation of globin expression in human and mouse erythroid cells, and CP2 binding to the globin gene promoter is essential for the enhanced transcription of globin genes in erythroid differentiation.
CP2 plays important role during bone development by activating BMP4 (显示 BMP4 抗体) transcription
A novel murine splice isoform of CP2, CP2b (显示 CYP27B1 抗体), which is identical to CP2a except that it has an additional 36 amino acids encoded by an extra exon was identified and characterized.
findings demonstrate that the APLP2-intracellular C-terminal domains interact with CP2 transcription factor in the nucleus and induce the expression of glycogen synthase kinase 3beta
This gene encodes a transcription factor that binds the alpha-globin promoter and activates transcription of the alpha-globin gene. The encoded protein regulates erythroid gene expression, plays a role in the transcriptional switch of globin gene promoters, and it activates many other cellular and viral gene promoters. The gene product interacts with certain inflammatory response factors, and polymorphisms of this gene may be involved in the pathogenesis of Alzheimer's disease.
transcription factor CP2
, cCP2 transcription factor
, SAA3 enhancer factor
, alpha-globin transcription factor CP2