TFE3 抗体
(Transcription Factor E3 (TFE3))
The microphthalmia transcription factor/transcription factor E (MITF-TFE) family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors includes four family members: MITF, TFE3, TFEB and TFEC. The TEF3 protein encoded by this gene activates transcription through binding to the muE3 motif of the immunoglobulin heavy-chain enhancer. The TFEC protein forms heterodimers with the TEF3 protein and inhibits TFE3-dependent transcription activation. The TEF3 protein interacts with transcription regulators such as E2F3, SMAD3, and LEF-1, and is involved in TGF-beta-induced transcription, playing important roles in cell growth, proliferation, and osteoclast and macrophage differentiation. The TFE3 protein also activates hepatic IRS-2 gene, and induces hexokinase II (HK2) and insulin-induced gene 1 (INSIG1)\; it participates in insulin signaling and could be a therapeutic target for diabetes. This gene is also involved in chromosomal translocations, resulting in different fusion gene products in papillary renal cell carcinomas and alveolar soft part sarcomas, such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NonO (p54nrb)-TFE3 and ASPL-TFE3.[provided by RefSeq, Dec 2009].
recommended
TFE3 适用: 人, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
recommended
recommended
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Latest Publications for our TFE3 抗体
: "Hypoxia induces TFE3 expression in head and neck squamous cell carcinoma." in: Oncotarget, Vol. 7, Issue 10, pp. 11651-63, (2016) (PubMed).: "Resetting transcription factor control circuitry toward ground-state pluripotency in human." in: Cell, Vol. 158, Issue 6, pp. 1254-69, (2014) (PubMed).
: "Exit from pluripotency is gated by intracellular redistribution of the bHLH transcription factor Tfe3." in: Cell, Vol. 153, Issue 2, pp. 335-47, (2013) (PubMed).
: "Derivation of novel human ground state naive pluripotent stem cells. ..." in: Nature, Vol. 504, Issue 7479, pp. 282-6, (2013) (PubMed).
: "Inactivation of the FLCN tumor suppressor gene induces TFE3 transcriptional activity by increasing its nuclear localization." in: PLoS ONE, Vol. 5, Issue 12, pp. e15793, (2011) (PubMed).
: "Myc/Max and other helix-loop-helix/leucine zipper proteins bend DNA toward the minor groove." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 24, pp. 11779-83, (1993) (PubMed).
: "TFEC, a basic helix-loop-helix protein, forms heterodimers with TFE3 and inhibits TFE3-dependent transcription activation." in: Molecular and cellular biology, Vol. 13, Issue 8, pp. 4505-12, (1993) (PubMed).
: "TFE3: a helix-loop-helix protein that activates transcription through the immunoglobulin enhancer muE3 motif." in: Genes & development, Vol. 4, Issue 2, pp. 167-79, (1990) (PubMed).
: "A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins." in: Cell, Vol. 56, Issue 5, pp. 777-83, (1989) (PubMed).
Aliases for TFE3 抗体
transcription factor binding to IGHM enhancer 3 (TFE3) 抗体transcription factor E3 (Tfe3) 抗体
transcription factor binding to IGHM enhancer 3 (Tfe3) 抗体
transcription factor binding to IGHM enhancer 3 S homeolog (tfe3.S) 抗体
transcription factor binding to IGHM enhancer 3a (tfe3a) 抗体
bHLHe33 抗体
cb873 抗体
F830016E06Rik 抗体
RCCP2 抗体
RCCX1 抗体
RGD1559642 抗体
Tcfe3 抗体
Tfe-3 抗体
TFEA 抗体
zgc:109815 抗体
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