This gene encodes a member of the sialic acid-binding immunoglobulin-like lectin family. These cell surface lectins are characterized by structural motifs in the immunoglobulin (Ig)-like domains and sialic acid recognition sites in the first Ig V set domain. This family member mediates anti-inflammatory and immunosuppressive signaling. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
Madge, Maggioni, Pascolutti, Amin, Waespy, Bellette, Thomson, Kelm, von Itzstein, Haselhorst: "Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy." in: Scientific reports, Vol. 6, pp. 36012, (2016) (PubMed).
Wang, Chow, Deng, Anderson, Weidner, Godwin, Bewtra, Zlotnik, Bui, Varki, Varki: "Expression of Siglec-11 by human and chimpanzee ovarian stromal cells, with uniquely human ligands: implications for human ovarian physiology and pathology." in: Glycobiology, Vol. 21, Issue 8, pp. 1038-48, (2011) (PubMed).
Clark, Gurney, Abaya, Baker, Baldwin, Brush, Chen, Chow, Chui, Crowley, Currell, Deuel, Dowd, Eaton, Foster, Grimaldi, Gu, Hass, Heldens, Huang, Kim, Klimowski, Jin, Johnson, Lee, Lewis, Liao, Mark et al.: "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. ..." in: Genome research, Vol. 13, Issue 10, pp. 2265-70, (2003) (PubMed).
Angata, Kerr, Greaves, Varki, Crocker, Varki: "Cloning and characterization of human Siglec-11. A recently evolved signaling molecule that can interact with SHP-1 and SHP-2 and is expressed by tissue macrophages, including brain microglia." in: The Journal of biological chemistry, Vol. 277, Issue 27, pp. 24466-74, (2002) (PubMed).
Aliases for SIGLEC11 抗体
sialic acid binding Ig like lectin 11 (SIGLEC11) 抗体