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The protein encoded by PPM1G is a member of the PP2C family of Ser/Thr protein phosphatases.
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Human PPM1G Protein expressed in Wheat germ - ABIN1315916
Khoronenkova, Dianova, Ternette, Kessler, Parsons, Dianov: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. in Molecular cell 2012
Human PPM1G Protein expressed in HEK-293 Cells - ABIN2729810
Richter, Dayaram, Gilmartin, Ganji, Pemmasani, Van Der Key, Shohet, Donehower, Kumar: WIP1 phosphatase as a potential therapeutic target in neuroblastoma. in PLoS ONE 2015
Nuclear phosphatase PPM1G in cellular survival and neural development.
PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 (显示 HEXIM1 蛋白) once P-TEFb (显示 CCNT1 蛋白) has been released from the 7SK snRNP (显示 LSM2 蛋白).
Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder.
PPM1G inactivates monomeric WWP2 (显示 WWP2 蛋白) and promotes the assembly of WWP2 (显示 WWP2 蛋白)-WWP1 (显示 WWP1 蛋白) heterodimeric complex.
PPM1G dephosphorylates the P-TEFb (显示 CCNT1 蛋白) kinase T loop to disassemble the 7SK snRNP (显示 LSM2 蛋白).
study has identified protein phosphatase PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosphorylation of 4E-BP1 (显示 EIF4EBP1 蛋白).
ATM (显示 ATM 蛋白)-dependent downregulation of USP7/HAUSP (显示 USP7 蛋白) by PPM1G activates p53 (显示 TP53 蛋白) response to DNA damage
The degradation of p21(WAF1/CIP1 (显示 CDKN1A 蛋白)) induced by PP2Cgamma was mediated in a proteasome-dependent manner.
Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes.
PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1 (显示 YBX1 蛋白).
an interplay between PPM1G and unrip (显示 STRAP 蛋白) determine compartment-specific phosphorylation patterns, localization, and function of the SMN (显示 STMN1 蛋白) complex
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.
, fibroblast growth factor inducible 13
, fibroblast growth factor-inducible protein 13
, protein phosphatase 1C
, protein phosphatase 1G
, protein phosphatase 2C isoform gamma
, protein phosphatase magnesium-dependent 1 gamma
, PP2C, gamma
, protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform
, protein phosphatase 2, catalytic subunit, gamma isoform
, protein phosphatase 2C gamma isoform
, magnesium-dependent calcium inhibitable phosphatase
, protein phosphatase 1B