Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G 蛋白 (PPM1G)

The protein encoded by PPM1G is a member of the PP2C family of Ser/Thr protein phosphatases.

列出全部蛋白 基因 基因ID UniProt
小鼠 PPM1G PPM1G 14208 Q61074
 PPM1G PPM1G 5496 O15355
大鼠 PPM1G PPM1G 259229  
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大肠杆菌(E. Coli) His tag 50 μg Log in to see 2至3个工作日
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$8,498.50
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 20至21个工作日
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大肠杆菌(E. Coli) His tag   50 μg Log in to see 4 Days
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
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大肠杆菌(E. Coli) His tag Validation with Western Blot 10 μg Log in to see 8至11个工作日
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大肠杆菌(E. Coli) His tag   10 μg Log in to see 15至16个工作日
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大肠杆菌(E. Coli) His tag   50 μg Log in to see 11至12个工作日
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引用最多的PPM1G 蛋白

  1. Human PPM1G Protein expressed in Wheat germ - ABIN1315916 : Khoronenkova, Dianova, Ternette, Kessler, Parsons, Dianov: ATM-dependent downregulation of USP7/HAUSP by PPM1G activates p53 response to DNA damage. in Molecular cell 2012 (PubMed)

  2. Human PPM1G Protein expressed in HEK-293 Cells - ABIN2729810 : Richter, Dayaram, Gilmartin, Ganji, Pemmasani, Van Der Key, Shohet, Donehower, Kumar: WIP1 phosphatase as a potential therapeutic target in neuroblastoma. in PLoS ONE 2015 (PubMed)

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Mouse (Murine) Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) interaction partners

  1. Nuclear phosphatase PPM1G in cellular survival and neural development.

Human Protein Phosphatase, Mg2+/Mn2+ Dependent, 1G (PPM1G) interaction partners

  1. PPM1G phosphatase directly binds 7SK RNA and the kinase inhibitor Hexim1 (显示 HEXIM1 蛋白) once P-TEFb (显示 CCNT1 蛋白) has been released from the 7SK snRNP (显示 LSM2 蛋白).

  2. Hypermethylation in the 3'-protein-phosphatase-1G (PPM1G) gene locus was associated with alcohol use disorder.

  3. PPM1G inactivates monomeric WWP2 (显示 WWP2 蛋白) and promotes the assembly of WWP2 (显示 WWP2 蛋白)-WWP1 (显示 WWP1 蛋白) heterodimeric complex.

  4. PPM1G dephosphorylates the P-TEFb (显示 CCNT1 蛋白) kinase T loop to disassemble the 7SK snRNP (显示 LSM2 蛋白).

  5. study has identified protein phosphatase PPM1G as a novel regulator of cap-dependent protein translation by negatively controlling the phosphorylation of 4E-BP1 (显示 EIF4EBP1 蛋白).

  6. ATM (显示 ATM 蛋白)-dependent downregulation of USP7/HAUSP (显示 USP7 蛋白) by PPM1G activates p53 (显示 TP53 蛋白) response to DNA damage

  7. The degradation of p21(WAF1/CIP1 (显示 CDKN1A 蛋白)) induced by PP2Cgamma was mediated in a proteasome-dependent manner.

  8. Protein phosphatase 2C gamma mediates histone dephosphorylation/exchange in response to DNA damage or checkpoint recovery in higher eukaryotes.

  9. PP2Cgamma modulates alternative splicing of specific pre-mRNAs coregulated by YB-1 (显示 YBX1 蛋白).

  10. an interplay between PPM1G and unrip (显示 STRAP 蛋白) determine compartment-specific phosphorylation patterns, localization, and function of the SMN (显示 STMN1 蛋白) complex

蛋白简介PPM1G

蛋白简介

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase is found to be responsible for the dephosphorylation of Pre-mRNA splicing factors, which is important for the formation of functional spliceosome. Studies of a similar gene in mice suggested a role of this phosphatase in regulating cell cycle progression.

Gene names and symbols associated with PPM1G

  • protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform (Ppm1g)
  • protein phosphatase, Mg2+/Mn2+ dependent 1G (PPM1G)
  • protein phosphatase, Mg2+/Mn2+ dependent, 1G (Ppm1g)
  • AI385652 蛋白
  • Fin13 蛋白
  • PP2CG 蛋白
  • PP2CGAMMA 蛋白
  • PPP2CG 蛋白

Protein level used designations for PPM1G

PP2C-gamma , fibroblast growth factor inducible 13 , fibroblast growth factor-inducible protein 13 , protein phosphatase 1C , protein phosphatase 1G , protein phosphatase 2C isoform gamma , protein phosphatase magnesium-dependent 1 gamma , PP2C, gamma , protein phosphatase 1G (formerly 2C), magnesium-dependent, gamma isoform , protein phosphatase 2, catalytic subunit, gamma isoform , protein phosphatase 2C gamma isoform , MCPP , magnesium-dependent calcium inhibitable phosphatase , protein phosphatase 1B

GENE ID SPECIES
14208 Mus musculus
5496 Homo sapiens
259229 Rattus norvegicus
286880 Bos taurus
475703 Canis lupus familiaris
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