anti-PHD Finger Protein 6 (PHF6) 抗体

PHF6 is a member of the plant homeodomain (PHD)-like finger (PHF) family. 再加上,我们可以发PHF6 蛋白 (7)PHF6 试剂盒 (4)和数多这个蛋白质的别的产品。

列出全部抗体 基因 基因ID UniProt
PHF6 84295 Q8IWS0
PHF6 70998 Q9D4J7
PHF6 100359714  
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antibodies-online.cn销售最多的anti-PHF6 抗体

Showing 10 out of 54 products:

产品编号 适用 宿主 标记 应用范围 图像 规格 供应商 交付 价格 详细
非结合性 WB WB Suggested Anti-PHF6 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:62500  Positive Control:  Human brain 100 μL Log in to see 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-PHF6 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2至3个工作日
Cow 非结合性 WB WB Suggested Anti-PHF6 Antibody Titration:  5.0ug/ml  Positive Control:  Jurkat cell lysate Sample Type: HEK293T cells transfected with a plasmid for over expression of myc-tagged PHF6Primary Dilution: 1:1000Secondary (goat anti-rabbit HRP) Dilution: 1:1000 100 μL Log in to see 2至3个工作日
非结合性 ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: PHF6 Antibody [NBP1-88646] - Staining of human colon shows strong nuclear positivity in glandular cells. Immunocytochemistry/Immunofluorescence: PHF6 Antibody [NBP1-88646] - Staining of human cell line U-251MG shows positivity in nucleus & nucleoli. 0.1 mL Log in to see 10至13个工作日
非结合性 ICC, IF, IHC (p), IP, IHC, WB Immunohistochemistry-Paraffin: PHF6 Antibody [ABIN2611761] - Detection of Mouse PHF6 by Immunohistochemistry. Sample: FFPE section of mouse renal cell carcinoma. Antibody: Affinity purified rabbit anti-PHF6 used at a dilution of 1:250. Detection: DAB staining using Immunohistochemistry Accessory Kit. 0.1 mL Log in to see 7至9个工作日
非结合性 ICC, IF, IHC, IHC (p), IP, WB Western Blot: PHF6 Antibody [ABIN2611772] - Image from a customer review testing on 293T cells. 0.1 mL Log in to see 7至9个工作日
非结合性 WB 100 μg Log in to see 11至14个工作日
Bat 非结合性 WB 100 μg Log in to see 11至14个工作日
非结合性 ICC, IF, IHC (p), IP, IHC, WB Western Blot: PHF6 Antibody [ABIN2611750] - Samples: Whole cell lysate from HeLa (5, 15 and 50 ug for WB; 1 mg for IP, 20% of IP loaded) and 293T (T; 50 ug) cells. Antibodies: Affinity purified rabbit anti-PHF6 antibody ABIN2611750 used for WB at 0.04 ug/ml (A) and 1 ug/ml (B) and used for IP at 3 ug/mg lysate. PHF6 was also immunoprecipitated by rabbit anti-PHF6 antibodies ABIN2611751 and ABIN2611752, which recognize downstream epitopes. Detection: Chemiluminescence with exposure times of 10 seconds (A) and 3 seconds (B). 0.1 mL Log in to see 7至9个工作日
非结合性 WB 100 μL Log in to see 16 Days

引用最多的anti-PHF6 抗体

  1. Human Polyclonal PHF6 Primary Antibody for ICC, IF - ABIN261177 : Meacham, Lawton, Soto-Feliciano, Pritchard, Joughin, Ehrenberger, Fenouille, Zuber, Williams, Young, Hemann: A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth. in Genes & development 2015 (PubMed)

  2. Human Polyclonal PHF6 Primary Antibody for ICC, IF - ABIN4345225 : Pontén, Jirström, Uhlen: The Human Protein Atlas--a tool for pathology. in The Journal of pathology 2008 (PubMed)


Human PHD Finger Protein 6 (PHF6) interaction partners

  1. EZH2 mutations coexisted with mutations of NOTCH1, IL7R, and PHF6 in the two Adult T-cell Acute Lymphoblastic Leukemia patients, and they responded poorly to chemotherapy and experienced difficult clinical histories and inferior outcomes

  2. PHF6 mutations occur at a low frequency in pediatric acute myeloid leukemia in both female and male patients

  3. PHF6 defects most likely result in their loss of function and have a substantial effect on the evolution into the aggressive types of myeloid neoplasms, associated with other concomitant genetic defects including RUNX1 mutations

  4. The mutations of the gene encoding plant homeodomain (PHD)-like finger protein 6 (PHF6) contribute to the pathogenesis of the X-linked intellectual disability disorder Borjeson-Forssman-Lehmann syndrome.

  5. PHF6 localizes to the sub-nucleolar fibrillar center where it binds to rDNA-coding sequences. PHF6 mediates the overall levels of ribosome biogenesis within a cell.

  6. Our results suggest that PHF6 may function as an oncogenic factor in several types of cancer. We also hypothesize that PHF6 may also play its role in a tissue-specific manner. Our findings suggest further investigations regarding the exact role of PHF6 in tumor types.

  7. Female phenotypes of Borjeson-Forssman-Lehmann syndrome patients with PHF6 mutations

  8. Our RBBP4-PHF6 complex structure provides insights into the molecular basis of PHF6-NuRD complex interaction and implicates a role for PHF6 in chromatin structure modulation and gene regulation.

  9. Phf6 is a "lineage-specific" cancer gene that plays opposing roles in developmentally distinct hematopoietic malignancies.

  10. The PHF6 tumor suppressor gene was targeted in acute lymphoblastic leukemia by microRNA-128-3p.

  11. Our report confirms that PHF6 loss in females results in a recognizable phenotype overlapping with Coffin-Siris syndrome and distinct from Borjeson-Forssman-Lehmann syndrome.

  12. Recurrent microdeletion was detected in Xq26.3, causing loss of PHF6 expression, a potential tumor suppressor gene, and the miR-424, which is involved in the development of acute myeloid leukemia.

  13. The findings show that de novo mutations in PHF6 in females result in a recognisable phenotype which overlap with Borjeson-Forssman-Lehmann syndrome but also has additional distinct features, thus adding a new facet to this disorder.

  14. these data support the hypothesis that PHF6 may function as a transcriptional repressor using its ePHD domains binding to the promoter region of its repressed gene

  15. Data suggest that mutations of PHF6 are associated with chronic myeloid leukemia (CML) progression.

  16. These results reveal that the key function of PHF6 is involved in regulating rRNA synthesis, which may contribute to its roles in cell cycle control, genomic maintenance, and tumor suppression.

  17. PHF6 interacts with the nucleosome remodeling and deacetylation complex and is localized primarily in the nucleoplasm and nucleolus.

  18. in T-cell acute lymphoblastic leukemia, PHF6 mutations are a recurrent genetic abnormality associated with mutations of NOTCH1, JAK1 and rearrangement of SET-NUP214.

  19. Our data suggest that PHF6 mutation might play a role in tumorigenesis not only of T-cell acute lymphoblatic leukemia, but also acute myelogenous leukemia and hepatocellular carcinoma.

  20. PHF6 as a tumor suppressor gene mutated in acute myeloid leukemias (AML) and extend the role of this X-linked tumor suppressor gene in the pathogenesis of hematologic tumors.

PHF6 抗原简介


This gene is a member of the plant homeodomain (PHD)-like finger (PHF) family. It encodes a protein with two PHD-type zinc finger domains, indicating a potential role in transcriptional regulation, that localizes to the nucleolus. Mutations affecting the coding region of this gene or the splicing of the transcript have been associated with Borjeson-Forssman-Lehmann syndrome (BFLS), a disorder characterized by mental retardation, epilepsy, hypogonadism, hypometabolism, obesity, swelling of subcutaneous tissue of the face, narrow palpebral fissures, and large ears. Alternate splicing results in multiple transcript variants, encoding different isoforms.

Gene names and symbols associated with anti-PHD Finger Protein 6 (PHF6) 抗体

  • PHD finger protein 6 (phf6) 抗体
  • PHD finger protein 6 L homeolog (phf6.L) 抗体
  • PHD finger protein 6 (PHF6) 抗体
  • PHD finger protein 6 (Phf6) 抗体
  • 2700007B13Rik 抗体
  • 4931428F02Rik 抗体
  • BFLS 抗体
  • BORJ 抗体
  • CENP-31 抗体
  • mKIAA1823 抗体
  • wu:fa22g03 抗体
  • zgc:55403 抗体

Protein level used designations for anti-PHD Finger Protein 6 (PHF6) 抗体

PHD finger protein 6 , PHD-like zinc finger protein , centromere protein 31

327070 Danio rerio
495066 Xenopus laevis
707390 Macaca mulatta
779543 Xenopus (Silurana) tropicalis
100151997 Sus scrofa
100225613 Taeniopygia guttata
100346149 Oryctolagus cuniculus
100379647 Monodelphis domestica
735789 Pan troglodytes
100054177 Equus caballus
84295 Homo sapiens
422235 Gallus gallus
612921 Canis lupus familiaris
518186 Bos taurus
70998 Mus musculus
100359714 Rattus norvegicus
100174671 Pongo abelii
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