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ODC1 encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine.
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Human Polyclonal ODC1 Primary Antibody for WB - ABIN518504
Ramot, Tiede, Bíró, Abu Bakar, Sugawara, Philpott, Harrison, Pietilä, Paus: Spermidine promotes human hair growth and is a novel modulator of human epithelial stem cell functions. in PLoS ONE 2011
Human Monoclonal ODC1 Primary Antibody for IF, IP - ABIN518505
Selmi, de Saint-Jean, Jallas, Garin, Hogarty, Bénard, Puisieux, Marabelle, Valsesia-Wittmann: TWIST1 is a direct transcriptional target of MYCN and MYC in neuroblastoma. in Cancer letters 2014
molecular cloning of species-specific enzyme and its antizyme-mediated degradation
Extracellular polyamines induced proliferation and cancer cell migration by inducing ODC and SSAT (显示 SAT1 抗体) expression, and the Akt1 (显示 AKT1 抗体)-mediated pathway.
Ornithine decarboxylase (ODC) plays a key role in prostate tumorigenesis and that the polyamine pathway is altered as early as high-grade prostate intraepithelial neoplasia (HGPIN).
Findings suggest that targeting ornithine decarboxylase 1 (ODC1) could be an attractive option for molecular therapy of hepatocellular carcinoma (HCC (显示 FAM126A 抗体)).
Binding of RS1 (显示 RS1 抗体)-Reg (显示 EXTL3 抗体) to ODC1 inhibits the enzymatic activity at low intracellular glucose, which is blunted at high intracellular glucose.
mechanistic study of the molecular interactions between antizyme inhibitor and its interacting proteins CCND1 (显示 CCND1 抗体) and ornithine decarboxylase
We earlier presented evidence for a physical interaction between ODC and SPR (显示 SPR 抗体) and we showed that RNAi-mediated knockdown of SPR (显示 SPR 抗体) expression significantly reduced native ODC enzyme activity and impeded Neuroblastoma (显示 ARHGEF16 抗体) cell proliferation.
Bag-1 (显示 BAG1 抗体) indirectly affects cell survival through c-Myc (显示 MYC 抗体) activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content.
High ODC expression is associated with Medulloblastoma.
Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN).
Data suggest that down-regulation of ODC (using siRNA or pharmacologic inhibitor) in bone marrow-derived mesenchymal stem cells results in reduced intracellular polyamines (putrescine, spermidine, and spermine) and enhanced osteogenesis.
Translation of ODC is therefore integral to cytoplasmic maturation, protecting metaphase II oocytes from reactive oxygen species-induced apoptosis.
We demonstrate that ornithine decarboxylase (ODC) regulates M1 activation during Helicobacter pylori and Citrobacter rodentium infection. Deletion of Odc in macrophages resulted in increased inflammation and decreased bacterial persistence in mouse models. The enhanced M1 response was due to alterations in histone modifications, resulting in changes in chromatin structure and up-regulated transcription.
these data support the hypothesis that TTP (显示 ZFP36 抗体) plays a role in the post-transcriptional regulation of the ODC mRNA transcript.
the Myc (显示 MYC 抗体)-ODC axis plays a critical role in the cellular transformation induced by myeloproliferative neoplasm-associated JAK2 (显示 JAK2 抗体) V617F mutant
Introduction of a fluorine atom at C3 of 3-deazauridine shifts its antimetabolic activity from inhibition of CTP synthetase (显示 CTPS 抗体) to inhibition of orotidylate decarboxylase, an early event in the de novo pyrimidine nucleotide biosynthesis pathway.
Androgens act via the AR to upregulate Odc1 in skeletal muscle myoblasts, and Odc1 promotes myoblast proliferation and delays differentiation.
the immunosuppression promoted by increased epidermal ODC is mediated by a reduction in cytokine levels, which suppresses dendritic cell migration and reduces immune cell infiltration to the site of hapten application
HuR (显示 ELAVL1 抗体) plays a causative role in ODC up-regulation during nonmelanoma skin cancer development by binding to and stabilizing the ODC transcript.
Overexpression of a dominant-negative ornithine decarboxylase in mouse skin: effect on enzyme activity and papilloma formation
In B16-F1 cells HGF (显示 HGF 抗体) increased AP-1 (显示 JUN 抗体) activity and the mRNA expression of various AP-1 (显示 JUN 抗体) subunits. HGF (显示 HGF 抗体)-induced transcription of mouse ODC was largely due to triggering of AP-1 (显示 JUN 抗体) pathway.
This gene encodes the rate-limiting enzyme of the polyamine biosynthesis pathway which catalyzes ornithine to putrescine. The activity level for the enzyme varies in response to growth-promoting stimuli and exhibits a high turnover rate in comparison to other mammalian proteins. Originally localized to both chromosomes 2 and 7, the gene encoding this enzyme has been determined to be located on 2p25, with a pseudogene located on 7q31-qter.
ornithine decarboxylase 1
, ornithine decarboxylase
, group IV decarboxylase
, Ornithine decarboxylase
, Ornitine decarboxylase
, ODC 1