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NUCB2 encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. 再加上，我们可以发Nucleobindin 2 试剂盒 (43) 和 Nucleobindin 2 蛋白 (28)和数多这个蛋白质的别的产品。
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Cow (Bovine) Polyclonal NUCB2 Primary Antibody for IHC, WB - ABIN2774832
Linē, Stengrēvics, Slucka, Li, Jankevics, Rees: Serological identification and expression analysis of gastric cancer-associated genes. in British journal of cancer 2002
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Human Polyclonal NUCB2 Primary Antibody for ICC, IF - ABIN4338639
Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. in Journal of proteomics 2012
Human Polyclonal NUCB2 Primary Antibody for IAC, IEM - ABIN2452060
Taniguchi, Taniura, Niinobe, Takayama, Tominaga-Yoshino, Ogura, Yoshikawa: The postmitotic growth suppressor necdin interacts with a calcium-binding protein (NEFA) in neuronal cytoplasm. in The Journal of biological chemistry 2000
It is confirmed herein that nesfatin-1 can regulate appetite in the pig and affect the gonadotropic axis of the prepubertal pig
Suggest that catecholaminergic and c-fos immunoreactive NUCB2/nesfatin-1 neurons could contribute in the anorexigenic effects of the mycotoxin deoxynivalenol.
Patients with schizophrenia had significantly higher serum nesfatin-1 levels compared to healthy controls.
This study finds that soccer matches performed different workout times have strong stimulatory effects on irisin (显示 FNDC5 抗体) levels in all subjects but nesfatin-1 response varied among the subjects and it did not change significantly in afternoon match.
serum nesfatin-1 concentrations were inversely correlated with atrial fibrillation development.
In all trimesters of human pregnancy, NUCB2/nesfatin-1 was highly expressed in syncytiotrophoblast. In addition, there was a significant increase in NUCB2 expression in human primary trophoblast cells induced to syncytialise.
Data suggest that circulating nesfatin-1 levels are up-regulated in patients newly diagnosed with type 2 diabetes; non-newly diagnosed patients treated with antidiabetic medications exhibit lower circulating nesfatin-1 levels. [META-ANALYSIS, REVIEW]
Data suggest that levels of nesfatin-1 in maternal serum and cord blood are up-regulated in women with gestational diabetes (GD) as compared to control pregnant women; nesfatin-1 also appears to be up-regulated in subcutaneous abdominal adipose tissue in GD. This study was conducted in China in women of the Han ethnicity.
expressions of p-Akt/Akt and p-GSK-3beta/GSK-3beta in the myocardium of MI group rats were significantly increased by nesfatin-1 administration, suggesting that nesfatin-1, which appears to possess anti-apoptotic and anti-inflammatory properties, may confer protection against ISO-induced MI via an Akt/GSK-3beta-dependent mechanism.
Study demonstrated that high expression level of NUCB2 was significantly associated with poor clinical outcome of patient with non-metastatic clear cell renal cell carcinoma (显示 MOK 抗体).
The multifunctional biological actions of nesfatin-1 propelled this peptide as a therapeutic target, and as a potential biomarker of diseases. However, a better and comprehensive understanding of tissue specific effects of nesfatin-1 is critical prior to exploring its possible use in the detection and treatment of diseases.
Data indicate that nesfatin-1/NUCB-2 enhanced migration, invasion and epithelial-mesenchymal transition (EMT (显示 ITK 抗体)) in colon cancer cells through LKB1 (显示 STK11 抗体)/AMPK (显示 PRKAA1 抗体)/TORC1 (显示 CRTC1 抗体)/ZEB1 (显示 ZEB1 抗体) pathways in vitro and in vivo.
Polymorphism in the exon 1, 2, 3, 4, 5, 6, 7, 8, 9, 10 and 11 of bovine NUCB2 gene was detected in 686 individuals from three Chinese cattle breeds.
NUCB2/nesfatin-1 is expressed in mouse placenta. Significant expression of NUCB2 in primary trophoblast cells during syncytialisation.
The results demonstrate a novel role of PDK1 (显示 PDPK1 抗体) in AgRP (显示 AGRP 抗体) neurons to counteract the high salt diet-induced hypertension by preventing hyperactivation of paraventricular nucleus nesfatin-1 neurons.
Nesfatin-1 promotes the differentiation of brown adipocytes likely through the mTOR (显示 FRAP1 抗体) dependent mechanism.
Because Kv channel inhibition enhances insulin (显示 INS 抗体) secretion under high glucose conditions, our present data suggest a possible mechanism of nesfatin-1 on enhancing glucose-stimulated insulin (显示 INS 抗体) secretion through regulation of ion channels rather than its unidentified receptor.
Tension receptor mechanosensitivity was unaffected by nesfatin-1 in SLD and fasted mice, but was inhibited in HFD mice. In conclusion, Nesfatin-1 modulates gastric vagal afferent mechanosensitivity in a nutritional state dependent manner.
Nesfatin-1 acts directly on hypothalamic neurons and gonadotropes to elicit a generally positive influence on the endocrine milieu regulating reproduction in mice. Reproductive hormones, in turn, modulate brain and pituitary NUCB2/nesfatin-1.
The results reveal that the endogenous NUCB2/nesfatin-1 in PVN regulates PVN AVP (显示 AVP 抗体) and oxytocin and consequently the fluid and energy balance.
Study provides evidence for direct regulation of hepatic lipid metabolism by nesfatin-1 through an AMPK (显示 PRKAA1 抗体)-dependent mechanism.
reproductive-endocrine regulation through hypothalamus-pituitary-ovary axis may contribute to nesfatin-1/NUCB2 expression in the pituitary gland.
new information on the cell specific localization of NUCB2/nesfatin-1 in the intestinal mucosa, and a novel function for nesfatin-1 in modulating intestinal CCK (显示 CCK 抗体) and PYY expression and secretion
This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains.
, DNA-binding protein NEFA
, gastric cancer antigen Zg4
, nucleobinding 2