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KMO encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. 再加上，我们可以发KMO 抗体 (72) 和 KMO 试剂盒 (21)和数多这个蛋白质的别的产品。
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Human KMO Protein expressed in HEK-293 Cells - ABIN2724434
Poda, Kobayashi, Nachane, Menon, Gandhi, Budac, Li, Campbell, Tagmose: Development of a Surface Plasmon Resonance Assay for the Characterization of Small-Molecule Binding Kinetics and Mechanism of Binding to Kynurenine 3-Monooxygenase. in Assay and drug development technologies 2015
Study shows that the development of depression-like behavior in the spared nerve injury model requires brain interleukin-1 signaling and activation of neuronal kynurenine 3-monoxygenase, while pain is independent of this pathway.
results demonstrate that the elimination of Kmo in mice is associated with multiple gene and functional alterations that appear to duplicate aspects of the psychopathology of several neuropsychiatric disorders.
These results suggest that increased KP metabolites reduced chemokine (显示 CCL1 蛋白) production, resulting in suppressed mortality upon KMO knockdown in EMCV infection. KP metabolites may thus provide an effective strategy for treating acute viral myocarditis.
The findings of this study suggested that KMO KO mice show antidepressants-responsive depressive-like behaviors and monoaminergic dysfunctions via abnormality of kynurenine metabolism with good validities as Major depressive disorder model.
Our data establish the candidacy of KMO as a causal factor for changes in the kidney leading to proteinuria and indicate a functional role for KMO and metabolites of the tryptophan pathway in podocytes
Mice lacking the enzyme kynurenine-3-monoxygenase (KMO) also showed no changes in hippocampal expression of several of these proteins or the 70-kDa and 100-kDa variants of Disrupted in Schizophrenia-1 (DISC1 (显示 DISC1 蛋白)).
KMO KO mice have a robust biochemical phenotype that protects against extrapancreatic tissue injury to the lung, kidney and liver in experimental acute pancreatitis-multiple organ dysfunction syndrome.
KMO knockout mice have alterations in the levels of several tryptophan metabolites.
expression of KMO by Th17 cells serves to limit their continuous exposure to physiological levels of endogenous aryl hydrocarbon receptor (显示 AHR 蛋白) ligands in vivo.
partial protection against cerebral malaria was observed in C57BL/6 mice treated with Ro 61-8048, an inhibitor of kynurenine-3-hydroxylase. Protection was associated with suppressed levels of picolinic acid within the brain.
results show the incidence of Postpartum Depression in the Chinese population to be 7.3%, with PDS (显示 SLC26A4 蛋白) characterized by increased serum 3-HydroxyKinurenine concentration and 3-HK/Kynurenine ratio, versus matched postpartum women without PDS (显示 SLC26A4 蛋白). Furthermore, polymorphisms of Kynurenine Monooxygenase rs1053230 are significantly associated with the incidence of PDS (显示 SLC26A4 蛋白).
A comprehensive review of the molecular properties of KMO, including its kinetics, reaction mechanism, and inhibitor structure-activity relationship (SAR (显示 SARDH 蛋白)), is not currently available and, thus, is our focus here
SiRNA knockdown of the pathway components Kynurenine 3-monooxygenase and quinolinate phosphoribosyl transferase caused cells to revert to a state of susceptibility to 3HK-mediated apoptosis.
These results suggest that KMO exhibits tumor-promoting effects towards hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)) and it may serve as a novel prognostic marker in HCC (显示 FAM126A 蛋白).
Results suggest that KMO variation influences a range of cognitive domains known to predict functional outcome in schizophrenia
Two KMO SNPs were observed more often in schizophrenia patient group compared with healthy controls.
findings from five independent cohorts suggest that genetic variation in KMO influences the risk for psychotic features in mania of bipolar disorder patients.
Study reporting on the first successful bacterial (Escherichia coli) expression of active FLAGtrade mark-tagged human KMO enzyme expressed in the soluble fraction and progress towards its purification.
analyzed association between KMO gene polymorphisms and CSF (显示 CSF2 蛋白) concentrations of kynurenic acid in patients with schizophrenia and controls. results suggest that the nonsynonymous KMO SNP rs1053230 influences CSF (显示 CSF2 蛋白) concentrations of KYNA.
The carboxyl-terminal region of pig liver L-kynurenine 3-monooxygenase plays a dual role as a mitochondrial-targeting signal and an enzyme.
This gene encodes a mitochondrion outer membrane protein that catalyzes the hydroxylation of L-tryptophan metabolite, L-kynurenine, to form L-3-hydroxykynurenine. Studies in yeast identified this gene as a therapeutic target for Huntington disease.
, kynurenine 3-monooxygenase
, L-kynurenine 3-monooxygenase Fpk