GDNF Family Receptor alpha 2 蛋白 (GFRA2)

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. 再加上,我们可以发GFRA2 抗体 (104)GFRA2 试剂盒 (3)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
GFRA2 2675 O00451
GFRA2 14586  
大鼠 GFRA2 GFRA2 25136  
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Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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HEK-293 Cells His tag 100 μg Log in to see 2至3个工作日
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人细胞 小鼠 His tag 100 μg Log in to see 14至16个工作日
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人细胞 His tag   50 μg Log in to see 4 Days
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人细胞 His tag 100 μg Log in to see 14至16个工作日
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人细胞 His tag   10 μg Log in to see 15至16个工作日
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HEK-293 Cells 非结合性 Validation with Western Blot 10 μg Log in to see 4至8个工作日
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HEK-293 Cells His tag Human GFR alpha-2, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 97%. 200 μg Log in to see 2至3个工作日
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酵母菌 Cow His tag   1 mg Log in to see 60至71个工作日
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GFRA2 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, ,
Mouse (Murine) , ,
,

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Human GDNF Family Receptor alpha 2 (GFRA2) interaction partners

  1. biophysical results show that the relative concentration of GFRa2 on cell surfaces can affect the functional affinity of NRTN through avidity effects.

  2. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase.

  3. High GFRalpha2 expression level leads to PTEN inactivation via Mir-17-5p up-regulation, promoting pancreatic tumor cell growth and chemoresistance.

  4. GFRA2 variants associated with diabetic neuropathic pain.

  5. GFRalpha2 is under-expressed in functioning adenomas and over-expressed in non-functioning adenomas, specifically gonadotropinomas

  6. In the cochlea, immunolabeling for GFRalpha-2 receptors was identified mainly in the cell bodies of the spiral neurons than in the nerve fibers. No structures in the organ of Corti were labeled with GFRalpha-2 receptor antibody

  7. The study shows co-localization of RET with GFRA1 and GFRA2 in myenteric ganglia of the adult human colon.

  8. GFRalpha-2 is associated with severe abdominal pain sensation in pancreatic cancer patients.

  9. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms.

  10. GFRA2 genetic variants, and age, may play a role in susceptibility to tardive dyskinesia.

  11. This study found nominally-significant evidence for interactions between GFRA1, 2 and 3 associated with schizophrenia and clozapine response, consistent with the locations of these three genes within linkage regions for schizophrenia.

  12. Both GFR alpha2a and GFR alpha2c, but not GFR alpha2b, promote neurite outgrowth in transfected Neuro2A cells.

  13. GFRalpha-2 were observed within sensory and motor nuclei of cranial nerves, dorsal column nuclei, olivary nuclear complex, reticular formation, pontine nuclei, locus caeruleus, raphe nuclei, substantia nigra, and quadrigeminal plate.

Mouse (Murine) GDNF Family Receptor alpha 2 (GFRA2) interaction partners

  1. The cardiac GFRA2 signaling pathway is distinct from the canonical pathway dependent on the RET tyrosine kinase.

  2. Ret and Gfra2 null mice display comparable early central projection deficits, but Gfra2 null rapidly adapting mechanoreceptors recover later.

  3. neurons switch their GFRalpha signaling pathways during postnatal development

  4. STAT3 phosphorylation by neurturin was found to be mediated specifically by GFRalpha2c and RET9 isoforms.

  5. Cholinergic innervation of gastric mucosa depends on neurturin-GFRalpha2 signalling but is dispensable for gastrin secretion and for basal and maximal acid output

  6. our data demonstrate that RET/GFRalpha signals are dispensable for thymic T cell development in vivo

  7. Transduction-function role for GFR alpha2/neurturin signalling in a specific class of sensory neurons.

  8. growth retardation in mice lacking GFRalpha2 is largely due to impaired salivary and pancreatic secretion and intestinal dysmotility.

  9. The cholinergic subpopulation of sympathetic neurons requires GFR alpha 2 signaling for soma size and for growth or maintenance of target innervation.

  10. The knockout mice of GFRalpha2 displayed significant impairment in contextual fear conditioning and conditioned taste aversion tests of memory.

  11. GFRalpha2 signaling is needed for development of the parasympathetic islet innervation that is critical for vagally induced hormone secretion.

  12. Critical role for endogenous GFRalpha2 signaling in maintaining the size and terminal innervation of the nonpeptidergic class of cutaneous nociceptors in vivo.

  13. Increased apoptosis of parasympathetic but not enteric neurons in the developing pancreas of mice lacking GFRalpha2.

  14. Demonstrate a role for GFRalpha2-expressing enteric neurons in the downstream signaling of the glucagon-like peptides to inhibit GI motility, but not in intestinal growth.

蛋白简介GFRA2

蛋白简介

Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with GFRA2

  • GDNF family receptor alpha 2 (GFRA2)
  • glial cell line derived neurotrophic factor family receptor alpha 2 (Gfra2)
  • GDNF family receptor alpha 2 (Gfra2)
  • GDNF family receptor alpha 2 (gfra2)
  • GDNF family receptor alpha 2a (gfra2a)
  • gdnfrb 蛋白
  • gfra2 蛋白
  • nrtnr-alpha 蛋白
  • ntnra 蛋白
  • NTNRALPHA 蛋白
  • retl2 蛋白
  • trnr2 蛋白

Protein level used designations for GFRA2

GDNF family receptor alpha-2 , GDNF receptor beta , GDNFR-alpha-2 , GDNFR-beta , GFR-alpha 2 , NTNR-alpha , PI-linked cell-surface accessory protein , RET ligand 2 , TGF-beta-related neurotrophic factor receptor 2 , TRN receptor, GPI-anchored , glial cell line derived neurotrophic factor receptor, beta , neurturin receptor alpha , GDNF receptor alpha-2 , GFR alpha 2 , GFR alpha-2 , GFR-alpha-2 , NRTNR-alpha , CDC42 binding protein kinase alpha (DMPK-like) , glial cell line derived neurotrophic factor family receptor alpha 2 , tyrosine kinase receptor ligand 2 , GDNF family receptor alpha 2 , GDNF family receptor alpha-2-like

GENE ID SPECIES
2675 Homo sapiens
14586 Mus musculus
100157850 Sus scrofa
25136 Rattus norvegicus
395993 Gallus gallus
514036 Bos taurus
100127717 Xenopus (Silurana) tropicalis
100171804 Pongo abelii
405794 Danio rerio
609172 Canis lupus familiaris
100475044 Ailuropoda melanoleuca
100727079 Cavia porcellus
100146260 Equus caballus
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