anti-PTEN (PTEN) 抗体产品概述

Full name:
anti-Phosphatase and Tensin Homolog 抗体 (PTEN)
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别名:
10q23del, 2310035O07Rik, A130070J02Rik, AI463227, B430203M17Rik, BZS, CWS1, DEC, GLM2, MHAM, Mmac, MMAC1, PTEN1, PTENP1, TEP1
列出全部抗体 基因 基因ID UniProt
小鼠 PTEN PTEN 19211 O08586
大鼠 PTEN PTEN 50557  
 PTEN PTEN 5728 P60484

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更多抗PTEN的相互作用对抗体

Mouse (Murine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. these results demonstrate that miR (显示 MLXIP 抗体)-26b might participate in regulating adipogenic differentiation in 3T3-L1 cells by inhibiting the PTEN expression, further highlighting the importance of miRNA in adipogenesis.

  2. Studies indicate complex PTEN-cooperating tumor suppressor networks in different cancer types, with potential clinical implications.

  3. Studies indicate that progesterone receptor (显示 PGR 抗体) transgenic (Pgrcre/+) mitogen inducible gene 6 (Mig (显示 CXCL9 抗体)-6over) phosphatase and tensin homolog protein (Ptenf/f) knockout mice exhibited an increase of phospho-ERK1/2 (显示 MAPK1/3 抗体) and its target genes.

  4. Studies indicate that the Pten+/- genotype displayed neoplasia in multiple organs, including the endometrium and that the Pten is a key regulatory player in the PI3K/PTEN/AKT (显示 AKT1 抗体) pathway.

  5. Using an extensive collection of novel murine cell lines we have identified distinct roles for Kras and Pten on MUC1 (显示 MUC1 抗体) and EMT (显示 ITK 抗体) in vivo and in vitro. The data has implications for future design of combination therapies targeting Kras mutations, Pten deletions and MUC1 (显示 MUC1 抗体) vaccines.

  6. novel role for PTEN during infection and identify regulation of the PI3K pathway, a mechanism previously shown to silence autoreactive B cells, as a key physiological target to control antibody responses.

  7. This study demonstrated Pten Regulates Retinal Amacrine Cell Number by Modulating Akt (显示 AKT1 抗体), Tgfbeta (显示 TGFB1 抗体), and Erk (显示 EPHB2 抗体) Signaling in mice.

  8. Tregs ameliorated ICH (显示 ACE 抗体)-induced inflammatory injury by modulating microglia/macrophage polarization toward the M2 phenotype through the IL-10 (显示 IL10 抗体)/GSK3beta (显示 GSK3b 抗体)/PTEN axis

  9. Data show that macrophage M2 polarization was mediated through PTEN/PI3k/AKT (显示 AKT1 抗体) pathway activation.

  10. this study shows this study shows that infection-induced miR (显示 MLXIP 抗体)-21 promotes severe, steroid-insensitive allergic airway disease by reducing PTEN expression

Human Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN rs701848 and AKT1 (显示 AKT1 抗体) rs2494752 polymorphisms might be a candidate pharmacogenomic factor to assess the susceptibility of and response and prognosis prediction for interindividualized CE(A)F chemotherapy in breast cancer patients.

  2. Meta-analysis demonstrates that PTEN loss is of particular importance for predicting breast cancer aggressiveness and poor prognosis. PTEN is a potential drug target for the development of individualized treatment in breast cancer patients.

  3. PTENp1 was aberrantly expressed in oral squamous cell carcinoma. There was a positive correlation between the expression levels of PTENp1 and PTEN. Further, we showed that PTENp1 acted as a competing endogenous RNA that protects PTEN transcripts from being inhibited by miR (显示 MLXIP 抗体)-21, and consequently inhibited proliferation and colony formation and triggered S-G2 (显示 STRN3 抗体)/M cell cycle arrest through the AKT (显示 AKT1 抗体) pathway.

  4. Results indicate that p110alpha (显示 PIK3CA 抗体) primarily mediates PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体) signaling in HER2 (显示 ERBB2 抗体)+ PTEN deficient breast tumors whereas p110beta conditionally mediates HER2 (显示 ERBB2 抗体)/PI3K (显示 PIK3CA 抗体) signaling in the absence of p110alpha (显示 PIK3CA 抗体).

  5. Her-2 (显示 ERBB2 抗体)-positive metastatic breast cancers, PTEN positivity was significantly associated with progressive disease, but not with PFS or OS

  6. Findings indicate that Epstein-Barr virus(EBV)-encoded latent membrane protein 1 (LMP1 (显示 PDLIM7 抗体)), PI3K (显示 PIK3CA 抗体)/AKT (显示 AKT1 抗体), miR (显示 MLXIP 抗体)-21 and PTEN constitute a positive feedback loop and have a key role in LMP1 (显示 PDLIM7 抗体)-induced cancer stem cells (CSCs) in nasopharyngeal carcinoma (NPC (显示 NPC1 抗体)).

  7. Coexpression of SALL4 (显示 SALL4 抗体) with HDAC1 (显示 HDAC1 抗体) and/or HDAC2 (显示 HDAC2 抗体) was associated with PTEN underexpression and a poor prognosis in hepatocellular carcinoma.

  8. PTEN promoter methylation is an independent predictor for impaired survival with malignant melanoma.

  9. Studies indicate that frequently altered genes in type I carcinomas are TP53, K-Ras, PTEN, and ss-catenin.

  10. Study provide evidence that PTEN deletion and TMPRSS2 (显示 TMPRSS2 抗体)-ERG (显示 ERG 抗体) gene fusion were mutually exclusive in patients with prostate neoplasm. TMPRSS2 (显示 TMPRSS2 抗体)-ERG (显示 ERG 抗体) gene fusion was rare compared to peripheral zone tumors and to PTEN inactivation in T1a (显示 PDPN 抗体) transition zone tumors.

Pig (Porcine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN, FOXO3A (显示 FOXO3 抗体) and PKB (显示 AKT1 抗体) were expressed in a stage- and cell-specific manner during ovarian follicle formation and development in the fetal and neonatal pig.

Cow (Bovine) Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. the miR-17-92 cluster is involved in granulosa cell proliferation and differentiation by coordinately targeting the PTEN and BMPR2 (显示 BMPR2 抗体) genes.

  2. miR (显示 MYLIP 抗体)-26b participates in the inflammatory response of LPS (显示 IRF6 抗体)-stimulated bAMs by modulating the NF-kappaB (显示 NFKB1 抗体) pathway through targeting PTEN.

  3. Pten expression levels in the mammary glands of dairy cows, was investigated.

  4. These studies identify a key role for PTEN in the modulation of lipid mediators involved in adenosine diphosphate receptor-regulated endothelial signaling pathways involving eNOS (显示 NOS3 抗体) activation in vascular endothelial cells.

  5. Overexpressing PTEN enhanced fatty acid oxidation and assembly and secretion of VLDL in cultured hepatocytes.

  6. Inhibition of PTEN activity had no effect on cyclic strain-mediated cell proliferation but inhibited cyclic strain-mediated suppression of apoptosis

Xenopus laevis Phosphatase and Tensin Homolog (PTEN) interaction partners

  1. PTEN plays an important role in multicilia formation and cilia disassembly by controlling the phosphorylation of Dishevelled (显示 DVL2 抗体).

  2. PTEN negatively regulates growth cone phosphatidylinositol 3,4,5-trisphosphate levels and mediates chemorepulsion, whereas chemoattraction is PTEN-independent.

  3. PTEN-dependent slowing of axonal growth enables the establishment of stable nerve-muscle contacts that develop into neuromuscular junctions.

PTEN 抗原简介

Antigen Summary

This gene was identified as a tumor suppressor that is mutated in a large number of cancers at high frequency. The protein encoded this gene is a phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase. It contains a tensin like domain as well as a catalytic domain similar to that of the dual specificity protein tyrosine phosphatases. Unlike most of the protein tyrosine phosphatases, this protein preferentially dephosphorylates phosphoinositide substrates. It negatively regulates intracellular levels of phosphatidylinositol-3,4,5-trisphosphate in cells and functions as a tumor suppressor by negatively regulating AKT\\/PKB signaling pathway.

Alternative names and synonyms associated with PTEN

  • phosphatase and tensin homolog (Pten) 抗体
  • phosphatase and tensin homolog (PTEN) 抗体
  • phosphatase and tensin homolog (pten) 抗体
  • 10q23del 抗体
  • 2310035O07Rik 抗体
  • A130070J02Rik 抗体
  • AI463227 抗体
  • B430203M17Rik 抗体
  • BZS 抗体
  • CWS1 抗体
  • DEC 抗体
  • GLM2 抗体
  • MHAM 抗体
  • Mmac 抗体
  • MMAC1 抗体
  • PTEN1 抗体
  • PTENP1 抗体
  • TEP1 抗体

Protein level used designations for PTEN

mutated in multiple advanced cancers 1 , phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN , protein tyrosine phosphatase and tensin-like protein , phosphatase and tensin homolog deleted on chromosome ten , phosphatase and tensin homolog (mutated in multiple advanced cancers 1) , MMAC1 phosphatase and tensin homolog deleted on chromosome 10 , phosphatase and tensin-like protein , homolog of human mutated in multiple advanced cancers , protein/lipid phosphatase Pten

GENE ID SPECIES
19211 Mus musculus
50557 Rattus norvegicus
423675 Gallus gallus
5728 Homo sapiens
403832 Canis lupus familiaris
100156264 Sus scrofa
540786 Bos taurus
399142 Xenopus laevis
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