Recombinant PTEN 抗体 (pSer380)
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- 抗原 See all PTEN 抗体
- PTEN (Phosphatase and Tensin Homolog (PTEN))
- 抗体类型
- Recombinant Antibody
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抗原表位
- pSer380
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This PTEN antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA
- 交叉反应
- 人
- 纯化方法
- Affinity-chromatography
- 免疫原
- A synthesized peptide derived from human Phospho-PTEN (S380)
- 克隆位点
- 4D10
- 亚型
- IgG
- Top Product
- Discover our top product PTEN Primary Antibody
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anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104), (N-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05082 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104) antibodyPTEN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 2-403) antibodyPTEN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295), (C-Term) antibodyPTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5083 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 306-335) antibodyPTEN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295) antibodyPTEN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) antibodyPTEN 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (acLys402) antibodyPTEN 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 363-392) antibodyPTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39439 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (C-Term) antibodyPTEN 适用: 人, 小鼠, 大鼠, 犬, Pig, 猴 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- PTEN (Phosphatase and Tensin Homolog (PTEN))
- 别名
- PTEN (PTEN 产品)
- 别名
- 10q23del antibody, BZS antibody, CWS1 antibody, DEC antibody, GLM2 antibody, MHAM antibody, MMAC1 antibody, PTEN1 antibody, TEP1 antibody, 2310035O07Rik antibody, A130070J02Rik antibody, AI463227 antibody, B430203M17Rik antibody, Mmac antibody, PTENP1 antibody, wu:fc52g04 antibody, zgc:73086 antibody, fa11a08 antibody, fb73f10 antibody, fc83f12 antibody, fd16b10 antibody, fk90e11 antibody, pten antibody, si:bz1g13.4 antibody, wu:fa11a08 antibody, wu:fb73f10 antibody, wu:fc83f12 antibody, wu:fd16b10 antibody, wu:fk90e11 antibody, phosphatase and tensin homolog antibody, phosphatase and tensin homolog L homeolog antibody, phosphatase and tensin homolog A antibody, phosphatase and tensin homolog B antibody, PTEN antibody, Pten antibody, pten.L antibody, ptena antibody, ptenb antibody
- 背景
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Background: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.
Aliases: Phosphatidylinositol 3, 4, 5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN, Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog, PTEN, MMAC1, TEP1
- UniProt
- P60484
- 途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
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