TRKA 蛋白 (NTRK1)产品概述

Full name:
Neurotrophic Tyrosine Kinase, Receptor, Type 1 蛋白 (NTRK1)
在www.antibodies-online.cn可供29 Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) 蛋白的9不同的供货商。 再加上,我们可以发TRKA 抗体 (452)TRKA 试剂盒 (37)和数多这个蛋白质的别的产品。 总共542 TRKA产品已列进来了。
别名:
C80751, CAPM1, CFTD, CTRKA, hscp30, MTC, NEM1, OK/SW-cl.5, p140-TrkA, Tkr, TM-5, TM3, TM5, TM30, TM30nm, TPMsk3, Trk, Trk-A, TRK1, trkA
列出全部蛋白 基因 基因ID UniProt
NTRK1 4914 P04629
NTRK1 18211 Q3UFB7
NTRK1 59109 P35739

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引用最多的TRKA 蛋白

  1. Human TRKA Protein expressed in Human Cells - ABIN2003909 : Bossemeyer, Borchard, Dosch, Helmer, Epstein, Booth, Bakker: K+-transport protein TrkA of Escherichia coli is a peripheral membrane protein that requires other trk gene products for attachment to the cytoplasmic membrane. in The Journal of biological chemistry 1989 (PubMed)
    Show all 5 references for 2003909

  2. Human TRKA Protein expressed in Escherichia coli (E. coli) - ABIN2003907 : Varsano, Dong, Niesman, Gacula, Lou, Ma, Testa, Yates, Farquhar: GIPC is recruited by APPL to peripheral TrkA endosomes and regulates TrkA trafficking and signaling. in Molecular and cellular biology 2006 (PubMed)
    Show all 5 references for 2003907

  3. Human TRKA Protein expressed in Human Cells - ABIN2003911 : Perrone, Paladino, Mazzone, Nitsch, Gulisano, Zurzolo: Functional interaction between p75NTR and TrkA: the endocytic trafficking of p75NTR is driven by TrkA and regulates TrkA-mediated signalling. in The Biochemical journal 2004 (PubMed)
    Show all 5 references for 2003911

  4. Rat (Rattus) TRKA Protein expressed in Human Cells - ABIN2009588 : Holtzman, Kilbridge, Li, Cunningham, Lenn, Clary, Reichardt, Mobley: TrkA expression in the CNS: evidence for the existence of several novel NGF-responsive CNS neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 1995 (PubMed)
    Show all 5 references for 2009588

  5. Dog (Canine) TRKA Protein expressed in Human Cells - ABIN2008971 : Lin, Quevedo, Brewer, Bell, Testa, Grimes, Miller, Kaplan: APPL1 associates with TrkA and GIPC1 and is required for nerve growth factor-mediated signal transduction. in Molecular and cellular biology 2006 (PubMed)
    Show all 5 references for 2008971

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Zebrafish Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) interaction partners

  1. By immunohistochemistry, the localization of Neurotrophinss has been observed mainly in Purkinje cells; TrkA and TrkB (显示 NTRK2 蛋白)-receptors in cells and fibers of granular and molecular layers. TrkC (显示 NTRK3 蛋白) was faintly detected

  2. TrkA-like immunoreactivity was the only Trk detected, and it was restricted to the somata of crypt sensory neurons, their central processes being apparently unreactive.

Rabbit Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) interaction partners

  1. report describing differential expression of proteins and mRNA for NGF (显示 NGFB 蛋白) and its cognate receptors, NTRK1 and NGFR (显示 NGFR 蛋白), in the male sex organs of rabbits

Human Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) interaction partners

  1. analysis of NTRK1 transcripts in peripheral blood cells of the patient revealed an influence of the variant on mRNA splicing. The C>A transversion generated a novel splice-site, which led to the incorporation of 10 intronic bases into the NTRK1 mRNA and consequently to a non-functional gene product.

  2. A novel nonsense mutation and a known splice-site mutation were detected in NTRK1 in two siblings and were shown to be associated with congenital insensitivity to pain with anhidrosis.

  3. NT3 (显示 NTF3 蛋白) upregulates cellular proliferation, extracellular matrix protein production, and collagen deposition in human aortic valve interstitial cells through the Trk-Akt (显示 AKT1 蛋白)-cyclin D1 (显示 CCND1 蛋白) cascade.

  4. NTRK1 gene fusion in spitzoid neoplasms results in tumors with Kamino bodies and were typically arranged in smaller nests with smaller predominantly spindle-shaped cells, occasionally forming rosettes.

  5. expression levels of tropomyosin 3 (TPM3 (显示 TPM3 蛋白)) were higher in stage III ESCC tissue compared with stage I (P<0.05). The findings of the present study identified twelve proteins, which are closely associated with ESCC invasion and metastasis, apoptosis and cell signal transduction.

  6. Results suggest that NTRK1 oncogenic activation through gene fusion defines a novel and distinct subset of soft tissue tumors resembling lipofibromatosis (LPF), but displaying cytologic atypia and a neural immunophenotype, provisionally named LPF-like neural tumors.

  7. This review highlights treatment options, including clinical trials for ROS1 rearrangement, RET fusions, NTRK1 fusions, MET exon skipping, BRAF mutations, and KRAS mutations.

  8. ShcD (显示 SHC4 蛋白) binds to active Ret (显示 RET 蛋白), TrkA, and TrkB (显示 NTRK2 蛋白) neurotrophic factor (显示 NTF3 蛋白) receptors predominantly via its phosphotyrosine-binding (PTB (显示 PTBP1 蛋白)) domain.

  9. Based on these current developments, the present review provides not only a broad overview of the biological effects of NGF-TrkA-p75NTR on cancer cells and their microenvironment, but also explains why NGF and its receptors are going to evoke major interest as promising therapeutic anti-cancer targets in the coming decade.

  10. TrkA misfolding and aggregation induced by some Insensitivity to Pain with Anhidrosis mutations disrupt the autophagy homeostasis causing neurodegeneration.

Mouse (Murine) Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) interaction partners

  1. These findings suggest that by interacting with PlexA4 (显示 PLXNA4 蛋白), TrkA plays a crucial role in redirecting local Sema3A (显示 SEMA3A 蛋白) signaling to retrograde axonal transport, thereby regulating dendritic GluA2 (显示 GRIA2 蛋白) localization and patterning.

  2. proposal that KIF1A (显示 KIF1A 蛋白) is essential for the survival and function of sensory neurons because of the TrkA transport and its synergistic support of the NGF (显示 NGFB 蛋白)/TrkA/PI3K signaling pathway

  3. As a result, overexpression of PTP (显示 SLC25A3 蛋白)-MEG2 (显示 PTPN9 蛋白) down-regulates NGF (显示 NGFB 蛋白)/TrkA signaling and blocks neurite outgrowth and differentiation

  4. TrkA misfolding and aggregation induced by some Insensitivity to Pain with Anhidrosis mutations disrupt the autophagy homeostasis causing neurodegeneration.

  5. USP36 actions extend beyond TrkA because the presence of USP36 interferes with Nedd4-2 (显示 NEDD4L 蛋白)-dependent Kv7.2 (显示 KCNQ2 蛋白)/3 channel regulation.

  6. functional PAP (显示 ASAP1 蛋白)(thorn) neurons are essential for the analgesic effect, which is mediated by NGF (显示 NGFB 蛋白)-trkA signaling.

  7. Dimeric dipeptide mimetics of the nerve growth factor Loop 4 and Loop 1 activate TRKA with different patterns of intracellular signal transduction.

  8. Data show that lysophosphatidic acid (LPA) induces phosphorylation of trkA receptor (TrkA) through lysophosphatidic acid receptor 1 (LPA1 (显示 LPAR1 蛋白)) binding to TrkA

  9. adult homozygous TrkAC knock-in mice displayed severe deficits in acute and tissue injury-induced pain, representing the first viable adult Trk mouse mutant with a pain phenotype

  10. IL-6 (显示 IL6 蛋白) may act as a new potential cumulus expansion-related transcript, which may be involved in the integration of TrkA and EGF (显示 EGF 蛋白) signaling in affecting expansion of cumulus oocyte complexes.

蛋白简介TRKA (NTRK1)

蛋白简介

This gene encodes a member of the tropomyosin family of actin-binding proteins involved in the contractile system of striated and smooth muscles and the cytoskeleton of non-muscle cells. Tropomyosins are dimers of coiled-coil proteins that polymerize end-to-end along the major groove in most actin filaments. They provide stability to the filaments and regulate access of other actin-binding proteins. In muscle cells, they regulate muscle contraction by controlling the binding of myosin heads to the actin filament. Mutations in this gene result in autosomal dominant nemaline myopathy, and oncogenes formed by chromosomal translocations involving this locus are associated with cancer. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with TRKA (NTRK1)

  • neurotrophic tyrosine kinase, receptor, type 1 (ntrk1)
  • neurotrophic tyrosine kinase, receptor, type 1 (NTRK1)
  • neurotrophic tyrosine kinase, receptor, type 1 (LOC100354292)
  • neurotrophic tyrosine kinase, receptor, type 1 (Ntrk1)
  • tropomyosin 3 (TPM3)
  • C80751 蛋白
  • CAPM1 蛋白
  • CFTD 蛋白
  • CTRKA 蛋白
  • hscp30 蛋白
  • MTC 蛋白
  • NEM1 蛋白
  • OK/SW-cl.5 蛋白
  • p140-TrkA 蛋白
  • Tkr 蛋白
  • TM-5 蛋白
  • TM3 蛋白
  • TM5 蛋白
  • TM30 蛋白
  • TM30nm 蛋白
  • TPMsk3 蛋白
  • Trk 蛋白
  • Trk-A 蛋白
  • TRK1 蛋白
  • trkA 蛋白

Protein level used designations for NTRK1

high affinity nerve growth factor receptor , tyrosine kinase receptor A , neurotrophic tyrosine kinase, receptor, type 1 , high affinity nerve growth factor receptor-like , tropomyosin-related kinase A , Oncogene TRK , TRK1-transforming tyrosine kinase protein , gp140trk , TrkA neurotrophin receptor , p140-TrkA , slow nerve growth factor receptor , trk , trk-A , trkA proto-oncogene receptor , neurotrophic tyrosine kinase receptor type 1 , tropomyosin receptor kinase , alpha-tropomyosin, slow skeletal , cytoskeletal tropomyosin TM30 , heat-stable cytoskeletal protein 30 kDa , tropomyosin alpha-3 chain , tropomyosin gamma , tropomyosin-5

GENE ID SPECIES
30546 Danio rerio
719670 Macaca mulatta
100064594 Equus caballus
100452269 Pongo abelii
100474165 Ailuropoda melanoleuca
457408 Pan troglodytes
490404 Canis lupus familiaris
100354292 Oryctolagus cuniculus
100585466 Nomascus leucogenys
100618744 Monodelphis domestica
4914 Homo sapiens
18211 Mus musculus
59109 Rattus norvegicus
353111 Bos taurus
396337 Gallus gallus
7170 Homo sapiens
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