TRKA Protein (AA 33-410) (Fc Tag)
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Quick Overview for TRKA Protein (AA 33-410) (Fc Tag) (ABIN7092732)
抗原
See all TRKA (NTRK1) 蛋白蛋白类型
宿主
资源
应用范围
纯度
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产品特性
- AA 33-410
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标记
- This TRKA protein is labelled with Fc Tag.
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原理
- Recombinant Human NTRK1 Protein with C-terminal human Fc tag
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特异性
- NTRK1(Ala33-Phe410) hFc(Glu99-Ala330)
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产品特性
- Extracellular Domain Protein
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纯化方法
- Purified from cell culture supernatant by affinity chromatography
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Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (Fc Tag)
NTRK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 90 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (Fc Tag)NTRK1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (His tag)NTRK1 宿主: 大鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1) (Active) protein (His tag)NTRK1 宿主: 小鼠 宿主: HEK-293 Cells Recombinant > 95 % as determined by SDS-PAGE Active
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应用备注
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Extracellular Domain Proteins (ECD) can be used as:
- Immunogens for antibody drug development
- Reagents used for CAR-T positive cell monitoring
- Reagents for antibody screening and functional testing
- Reagents for antibody affinity measurement
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说明
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The protein was produced using HEK293 mammalian cell secretion expression system to ensure the close-to-native structures and post-translational modifications of the target protein.
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Please see Certificate of Analysis for specific instructions of reconstitution.
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缓冲液
- Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
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储存条件
- -20 °C,-80 °C
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储存方法
- Store at -20°C to -80°C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80°C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
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有效期
- 12 months
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- TRKA (NTRK1) (Neurotrophic Tyrosine Kinase, Receptor, Type 1 (NTRK1))
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别名
- NTRK1
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背景
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MTC,p140-TrkA,TRK,Trk-A,TRK1,TRKA
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, cognitive disability and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq, Jul 2008] -
分子量
- predicted molecular mass of 67.4 kDa after removal of the signal peptide.The apparent molecular mass of NTRK1-hFc is 70-130 kDa due to glycosylation.
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UniProt
- P04629
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途径
- RTK signaling, Neurotrophin Signaling Pathway, cAMP Metabolic Process
抗原
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