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|抗原||Met Proto-Oncogene (MET) 抗体|
|抗原表位||AA 1-935 其他选择|
|标记||This MET antibody is un-conjugated 其他选择|
|Supplier||Log in to see|
MET抗体详情MET目标详情 使用细节 贮存及处理 References for anti-MET antibody (ABIN2001505) 图像
|特异性||Canine HGFR / c-MET|
|产品特性||Produced in rabbits immunized with purified, recombinant Canine HGFR / c-MET (rCanine HGFR / c-MET, ABIN2008842 NP_001002963.1, Met 1-Leu 935,. HGFR / c-MET specific IgG was purified by Canine HGFR / c-MET affinity chromatography.|
|纯化方法||purified by affinity chromatography|
|过滤||0.2 μm filtered|
|免疫原||Recombinant Canine HGFR / c-MET protein (ABIN2008842)|
MET目标详情MET抗体详情 使用细节 贮存及处理 References for anti-MET antibody (ABIN2001505) 图像 回页首
|别名||MET (MET Antibody 摘要)|
|背景||Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.|
|途径||RTK signaling, Carbohydrate Homeostasis, Synaptic Membrane, Signaling of Hepatocyte Growth Factor Receptor|
使用细节MET抗体详情 MET目标详情 贮存及处理 References for anti-MET antibody (ABIN2001505) 图像 回页首
ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Canine MET. The detection limit for Canine MET is approximately 0.00975 ng/well.
贮存及处理MET抗体详情 MET目标详情 使用细节 References for anti-MET antibody (ABIN2001505) 图像 回页首
|缓冲液||0.2 μm filtered solution in PBS with 5 % trehalose|
|注意事项||Avoid repeated freeze-thaw cycles.|
|储存条件||4 °C,-20 °C,-80 °C|
This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
References for anti-MET antibody (ABIN2001505)MET抗体详情 MET目标详情 使用细节 贮存及处理 图像 回页首
Socoteanu, Mott, Alpini, Frankel: "c-Met targeted therapy of cholangiocarcinoma." in: World journal of gastroenterology : WJG, Vol. 14, Issue 19, pp. 2990-4, 2008
McGill, Haq, Nishimura, Fisher: "c-Met expression is regulated by Mitf in the melanocyte lineage." in: The Journal of biological chemistry, Vol. 281, Issue 15, pp. 10365-73, 2006