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anti-Insulin Receptor Substrate 1 (IRS1) 抗体产品概述

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anti-Insulin Receptor Substrate 1 抗体 (IRS1)
在www.antibodies-online.cn可供593 Insulin Receptor Substrate 1 (IRS1) 抗体的30不同的供货商。 再加上,我们可以发Insulin Receptor Substrate 1 试剂盒 (45)Insulin Receptor Substrate 1 蛋白 (6)和数多这个蛋白质的别的产品。 总共668 Insulin Receptor Substrate 1产品已列进来了。
别名:
G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu

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引用最多的anti-Insulin Receptor Substrate 1 抗体

  1. Human Polyclonal IRS1 Primary Antibody for EIA, IF - ABIN500072 : Giovannone, Scaldaferri, Federici, Porzio, Lauro, Fusco, Sbraccia, Borboni, Lauro, Sesti: Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential. in Diabetes/metabolism research and reviews 2001 (PubMed)
    Show all 4 references for ABIN500072

  2. Human Polyclonal IRS1 Primary Antibody for IHC (p), WB - ABIN196978 : Ozes, Akca, Mayo, Gustin, Maehama, Dixon, Donner: A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 4 references for ABIN196978

  3. Human Polyclonal IRS1 Primary Antibody for IF, IHC - ABIN1531876 : Simon-Szabó, Kokas, Mandl, Kéri, Csala: Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. in PLoS ONE 2014 (PubMed)
    Show all 2 references for ABIN1531876

  4. Human Polyclonal IRS1 Primary Antibody for EIA - ABIN118052 : Cho, Nam, An, Lim: Replicable and shape-controllable fabrication of electrospun fibrous scaffolds for tissue engineering. in Journal of nanoscience and nanotechnology 2013 (PubMed)
    Show all 2 references for ABIN118052

  5. Human Polyclonal IRS1 Primary Antibody for ELISA, WB - ABIN129580 : Shah, Hunter: Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. in Molecular and cellular biology 2006 (PubMed)

  6. Human Polyclonal IRS1 Primary Antibody for IF, IHC - ABIN1532908 : Araki, Sun, Haag, Chuang, Zhang, Yang-Feng, White, Kahn: Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. in Diabetes 1993 (PubMed)

更多抗Insulin Receptor Substrate 1的相互作用对抗体

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. TBC1D4 (显示 TBC1D4 抗体), insulin receptor (显示 INSR 抗体) and GLUT4 (显示 SLC2A4 抗体) showed altered expression in some tissues in pre-diabetic pigs.

  2. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Human Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (显示 IRS2 抗体) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (显示 INSR 抗体) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

  2. IRS1 Gene Polymorphism is associated with Autism Spectrum Disorder.

  3. High IRS1 expression is associated with hepatocellular carcinoma.

  4. In the renal proximal tubule, insulin (显示 INS 抗体) signaling via IRS1 is inhibited, while insulin (显示 INS 抗体) signaling via IRS2 (显示 IRS2 抗体) is preserved. Insulin (显示 INS 抗体) signaling via IRS2 (显示 IRS2 抗体) continues to stimulate sodium reabsorption in the proximal tubule and causes sodium retention, edema, and hypertension.

  5. miR-195 inhibits tumor angiogenesis through suppressing IRS1-VEGF axis.

  6. The Arg(972) IRS-1 polymorphism is associated with increased risk and disease activity/severity of rheumatoid arthritis, and therefore may be a potential prognostic factor for RA.

  7. In this exploratory analysis, IRS1, ENNP1 and TRIB3 (显示 TRIB3 抗体), known to be associated with type 2 diabetes and harboring genes playing a prominent role in mediating insulin (显示 INS 抗体) signaling, may modulate a number of cardiometabolic phenotypes in patients of Italian ancestry with newly-diagnosed type 2 diabetes.

  8. In accordance with previous studies, our findings suggest that the IRS1 G972R R allele and RR+GR genotype have protective effects for colorectal cancer (CRC (显示 CALR 抗体)) in overweight/obese patients and for obesity in patients with CRC (显示 CALR 抗体).

  9. FRET-based translocation assays reveal that insulin (显示 INS 抗体) promotes the association of both p62 (显示 GTF2H1 抗体) and aPKC with the insulin (显示 INS 抗体)-regulated scaffold IRS-1.

  10. HCV NS5A favors serine phosphorylation of IRS-1, promoting insulin (显示 INS 抗体) resistance through IRS-1 serine phosphorylation and increased gluconeogenesis.

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Acute knockdown of Insr (显示 INSR 抗体) or both Irs1 and Irs2 (显示 IRS2 抗体) in adipocytes increased Adipoq (显示 ADIPOQ 抗体) mRNA expression but reduced adiponectin (显示 ADIPOQ 抗体) secretion.

  2. Concentration of SOCS-3 (显示 SOCS3 抗体) protein and coimmunoprecipitation of SOCS-3 (显示 SOCS3 抗体) protein with both the IR-beta subunit (显示 POLG 抗体) as well as IRS-1 was found to be decreased by 4-HIL

  3. Authors propose that insulin (显示 INS 抗体)/IGF-1 (显示 IGF1 抗体) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (显示 PROP1 抗体) longevity phenotype.

  4. within the hepatic compartment, mTORC1 --> S6K (显示 RPS6KB1 抗体) signaling regulates Akt (显示 AKT1 抗体) largely through IRS (显示 IARS 抗体)-independent means with little effect upon physiologic insulin (显示 INS 抗体) sensitivity.

  5. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (显示 FAM126A 抗体) development and progression.

  6. Insulin receptor substrate-1-mediated insulin (显示 INS 抗体) signal transduction may be an important factor in the treatment of cognitive decline induced by insulin (显示 INS 抗体) resistance.

  7. Full Length Irs-1 transcript functions as a bifunctional RNA during myogenic differentiation.

  8. melatonin can ameliorate insulin (显示 INS 抗体) sensitivity by inhibiting Ser307 phosphorylation in IRS-1

  9. Most importantly, treatment of cells with the RhoA (显示 RHOA 抗体)/ROCK inhibitor, Y-27632, which among its many effects also inhibited serine 636 phosphorylation of IRS-1, had profound effects on cell-substratum adhesion

  10. Results indicate that although IRS (显示 IARS 抗体) isoforms (irs1 and irs2 (显示 IRS2 抗体)) play divergent roles in the developmental regulation of cardiac size, these isoforms exhibit nonredundant roles in mediating the hypertrophic and metabolic response of the heart to exercise.

Rabbit Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (显示 FTO 抗体) genes regulates body weight in rabbits.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (显示 PAX6 抗体) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) 抗原简介

Antigen Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

  • insulin receptor substrate 2 (irs2) 抗体
  • insulin receptor substrate 1 (IRS1) 抗体
  • insulin receptor substrate 1 (Irs1) 抗体
  • insulin receptor substrate 1 (irs1) 抗体
  • G972R 抗体
  • HIRS-1 抗体
  • irs-1 抗体
  • IRS1 抗体
  • irs1-a 抗体
  • IRS1IRM 抗体
  • irsu 抗体

Protein level used designations for IRS1

IRS-1 , insulin receptor substrate 1 , pp185 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

GENE ID SPECIES
394823 Xenopus (Silurana) tropicalis
429126 Gallus gallus
459985 Pan troglodytes
100271862 Felis catus
100294708 Sus scrofa
100607873 Nomascus leucogenys
3667 Homo sapiens
16367 Mus musculus
25467 Rattus norvegicus
429262 Gallus gallus
538598 Bos taurus
100512686 Sus scrofa
100716939 Cavia porcellus
486148 Canis lupus familiaris
100339981 Oryctolagus cuniculus
101102293 Ovis aries
399299 Xenopus laevis
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