anti-Insulin Receptor Substrate 1 (IRS1) 抗体产品概述

Full name:
anti-Insulin Receptor Substrate 1 抗体 (IRS1)
在www.antibodies-online.cn可供586 Insulin Receptor Substrate 1 (IRS1) 抗体的30不同的供货商。 再加上,我们可以发Insulin Receptor Substrate 1 试剂盒 (50)Insulin Receptor Substrate 1 蛋白 (6)和数多这个蛋白质的别的产品。 总共666 Insulin Receptor Substrate 1产品已列进来了。
G972R, HIRS-1, irs-1, IRS1, irs1-a, IRS1IRM, irsu

所有可销售的anti-Insulin Receptor Substrate 1 抗体


引用最多的anti-Insulin Receptor Substrate 1 抗体

  1. Human Polyclonal IRS1 Primary Antibody for IHC (p), WB - ABIN196980 : Ozes, Akca, Mayo, Gustin, Maehama, Dixon, Donner: A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. in Proceedings of the National Academy of Sciences of the United States of America 2001 (PubMed)
    Show all 4 references for 196980

  2. Human Polyclonal IRS1 Primary Antibody for IF, IHC (p) - ABIN197466 : Tzatsos, Kandror: Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. in Molecular and cellular biology 2005 (PubMed)
    Show all 4 references for 197466

  3. Human Polyclonal IRS1 Primary Antibody for IF, IHC - ABIN1531876 : Simon-Szabó, Kokas, Mandl, Kéri, Csala: Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. in PLoS ONE 2014 (PubMed)
    Show all 2 references for 1531876

  4. Human Polyclonal IRS1 Primary Antibody for IF, ELISA - ABIN1531877 : Araki, Sun, Haag, Chuang, Zhang, Yang-Feng, White, Kahn: Human skeletal muscle insulin receptor substrate-1. Characterization of the cDNA, gene, and chromosomal localization. in Diabetes 1993 (PubMed)

  5. Human Polyclonal IRS1 Primary Antibody for IF (p), IHC (p) - ABIN749873 : Luo, Yang, Tang, Yao, Kong, He, Zhou: Kaempferol alleviates insulin resistance via hepatic IKK/NF-?B signal in type 2 diabetic rats. in International immunopharmacology 2015 (PubMed)

  6. Human Polyclonal IRS1 Primary Antibody for ELISA, WB - ABIN129580 : Shah, Hunter: Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. in Molecular and cellular biology 2006 (PubMed)

更多抗Insulin Receptor Substrate 1的相互作用对抗体

Pig (Porcine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. miR (显示 MYLIP 抗体)-146a-5p targets porcine insulin receptor (显示 INSR 抗体) and could inhibit its protein expression.

  2. TBC1D4 (显示 TBC1D4 抗体), insulin receptor (显示 INSR 抗体) and GLUT4 (显示 SLC2A4 抗体) showed altered expression in some tissues in pre-diabetic pigs.

  3. Association analysis of genotypes with growth traits, anatomy traits, meat quality traits and physiological biochemical indexes traits showed that different genotypes at locus 3,257 of IRS-1 have significant differences in carcass straight length in pigs.

Human Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Allele and genotype frequencies of rs1801278 in IRS1 showed significant differences between cases and controls for obstructive sleep apnea risk in Chinese Han population.

  2. Gly972Arg of IRS-1 polymorphisms are associated with polycystic ovary syndrome.

  3. G allele of the rs7578326 SNP in the LOC646736/IRS1 region is significantly associated with gestational diabetes mellitus.

  4. The results suggest that high glucose compromises the insulin (显示 INS 抗体) signaling pathway in the glomerulus, promoting a proapoptotic environment, with a possible critical step for this malfunction lying at the level of IRS-1 phosphorylation.

  5. The C-allele of IRS1 variant rs2943650 was significantly associated with higher Body Fat Percentage overall and was significantly associated with lower levels of fasting insulin, homeostatic model assessment of insulin resistance, hemoglobin A1c, and triglycerides and higher high-density lipoprotein cholesterol in United States Hispanics/Latinos.

  6. IRS-1 and IRS-2 (显示 IRS2 抗体) signaling interaction with the microtubule cytoskeleton and its response to AKT (显示 AKT1 抗体) determines the response to microtubule disruption in breast carcinoma cells

  7. Findings suggest that the induction of microRNA miR (显示 MLXIP 抗体)-1271 by saturated fatty acid palmitate promotes the development of insulin (显示 INS 抗体) resistance by targeting insulin receptor (INSR (显示 INSR 抗体)) and insulin receptor substrate 1 protein (IRS-1) in hepatocytes.

  8. The study results were suggestive of a positive association between Gly972Arg of IRS1 and PCOS in the south Indian population, while INS (显示 INS 抗体), IRS2 (显示 IRS2 抗体), PPAR-G (显示 ARF6 抗体) and CAPN10 (显示 CAPN10 抗体) failed to show any association with PCOS in our studied population.

  9. Consistent with these observations, LPIN1 (显示 LPIN1 抗体) levels were positively correlated with IRS1 expression in human breast cancer. Thus, our results indicate a mechanism by which IRS1 expression is increased in breast cancer, and LPIN1 (显示 LPIN1 抗体) may be a promising drug target for anticancer therapy

  10. Findings suggest that insulin receptor substrate -1 Gly972Arg polymorphism is associated with polycystic ovary syndrome in the Caucasian ethnicity, and insulin receptor substrate -2 (显示 IRS2 抗体) Gly1057Asp polymorphism is correlated with polycystic ovary syndrome in the Asian ethnicity. However, insulin receptor (显示 INSR 抗体) His 1058 C/T polymorphism may not be implicated in polycystic ovary syndrome.

Mouse (Murine) Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Insulin receptor substrate-1 time-dependently regulates bone formation by controlling collagen Ialpha2 expression via miR (显示 MLXIP 抗体)-342

  2. Irs1 was downregulated in the arcuate nucleus of type 2 diabetic mice.

  3. In conclusion, we have identified that ARL15 acts as an insulin (显示 INS 抗体)-sensitizing effector molecule to upregulate the phosphorylation of members of the canonical IR/IRS1/PDPK1 (显示 PDPK1 抗体)/AKT (显示 AKT1 抗体) insulin (显示 INS 抗体) pathway by interacting with its GAP ASAP2 (显示 ASAP2 抗体) and activating PDPK1 (显示 PDPK1 抗体). This research may provide new insights into GTPase (显示 RACGAP1 抗体)-mediated insulin (显示 INS 抗体) signalling regulation and facilitate the development of new pharmacotherapeutic targets for insulin (显示 INS 抗体) sensitizati

  4. These findings illuminate a new function of IRS-1: that of maintaining cells in their normal, differentiated state. Because IRS-1 is down-regulated in states of insulin (显示 INS 抗体) resistance that occur in response to metabolic stresses such as obesity and cytokine stimulation

  5. Decreased miR (显示 MLXIP 抗体)-33 levels can up-regulate IRS-2 (显示 IRS2 抗体) expression, which appears to compensate for the defects of the insulin (显示 INS 抗体) signaling pathway in Irs-1 deficient mice.

  6. Acute knockdown of Insr (显示 INSR 抗体) or both Irs1 and Irs2 (显示 IRS2 抗体) in adipocytes increased Adipoq (显示 ADIPOQ 抗体) mRNA expression but reduced adiponectin (显示 ADIPOQ 抗体) secretion.

  7. Concentration of SOCS-3 (显示 SOCS3 抗体) protein and coimmunoprecipitation of SOCS-3 (显示 SOCS3 抗体) protein with both the IR-beta subunit (显示 POLG 抗体) as well as IRS-1 was found to be decreased by 4-HIL

  8. Authors propose that insulin (显示 INS 抗体)/IGF-1 (显示 IGF1 抗体) cross talk and level of phosphorylation of specific IRS-1 serines may promote the Ames dwarf (显示 PROP1 抗体) longevity phenotype.

  9. within the hepatic compartment, mTORC1 --> S6K (显示 RPS6KB1 抗体) signaling regulates Akt (显示 AKT1 抗体) largely through IRS (显示 IARS 抗体)-independent means with little effect upon physiologic insulin (显示 INS 抗体) sensitivity.

  10. Sustained overexpression of HBx and IRS1 led to constitutive activation of a tripartite growth factor signal transduction cascade in the liver and was necessary and sufficient to promote HCC (显示 FAM126A 抗体) development and progression.

Rabbit Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. IRS1 gene was associated with growth traits in rabbits.Association between the IRS1 and FTO (显示 FTO 抗体) genes regulates body weight in rabbits.

Xenopus laevis Insulin Receptor Substrate 1 (IRS1) interaction partners

  1. Knock down of IRS-1 in neural tissue by specific antisense morpholino oligonucleotides (MO) resulted in abnormal eye formation accompanied by reduction of the eye-specific marker genes Rx1 and Pax6 (显示 PAX6 抗体) and a decreased cell proliferation.

Insulin Receptor Substrate 1 (IRS1) 抗原简介

Antigen Summary

This gene encodes a protein which is phosphorylated by insulin receptor tyrosine kinase. Mutations in this gene are associated with type II diabetes and susceptibility to insulin resistance.

Alternative names and synonyms associated with Insulin Receptor Substrate 1 (IRS1)

  • insulin receptor substrate 2 (irs2) 抗体
  • insulin receptor substrate 1 (IRS1) 抗体
  • insulin receptor substrate 1 (Irs1) 抗体
  • insulin receptor substrate 1 (irs1) 抗体
  • G972R 抗体
  • HIRS-1 抗体
  • irs-1 抗体
  • IRS1 抗体
  • irs1-a 抗体
  • IRS1IRM 抗体
  • irsu 抗体

Protein level used designations for IRS1

IRS-1 , insulin receptor substrate 1 , pp185 , XIRS-L , insulin receptor substrate 1-A , xIRS-1-A

394823 Xenopus (Silurana) tropicalis
429126 Gallus gallus
459985 Pan troglodytes
100271862 Felis catus
100294708 Sus scrofa
100607873 Nomascus leucogenys
3667 Homo sapiens
16367 Mus musculus
25467 Rattus norvegicus
429262 Gallus gallus
538598 Bos taurus
100512686 Sus scrofa
100716939 Cavia porcellus
486148 Canis lupus familiaris
100339981 Oryctolagus cuniculus
101102293 Ovis aries
399299 Xenopus laevis
anti-Insulin Receptor Substrate 1 (IRS1) 抗体 精选生产商