anti-Retinoblastoma 1 (RB1) 抗体产品概述

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anti-Retinoblastoma 1 抗体 (RB1)
在www.antibodies-online.cn可供628 Retinoblastoma 1 (RB1) 抗体的29不同的供货商。 再加上,我们可以发Retinoblastoma 1 试剂盒 (40)Retinoblastoma 1 蛋白 (16)和数多这个蛋白质的别的产品。 总共754 Retinoblastoma 1产品已列进来了。
别名:
OSRC, P105-RB, PP110, pRb, Rb, Rb-1, RB1, RB11, zgc:154147

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引用最多的anti-Retinoblastoma 1 抗体

  1. Human Polyclonal Retinoblastoma 1 Primary Antibody for EIA, IHC (p) - ABIN358210 : Wagner, Roemer: Retinoblastoma protein is required for efficient colorectal carcinoma cell apoptosis by histone deacetylase inhibitors in the absence of p21Waf. in Biochemical pharmacology 2005 (PubMed)
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  2. Human Polyclonal Retinoblastoma 1 Primary Antibody for EIA, IHC (p) - ABIN358212 : Yan, Bell, Breeden, Ellington: Aptamers: prospects in therapeutics and biomedicine. in Frontiers in bioscience : a journal and virtual library 2005 (PubMed)
    Show all 5 references for 358212

  3. Human Polyclonal Retinoblastoma 1 Primary Antibody for EIA, IHC (p) - ABIN358214 : Roesch, Becker, Meyer, Hafner, Wild, Landthaler, Vogt: Overexpression and hyperphosphorylation of retinoblastoma protein in the progression of malignant melanoma. in Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2005 (PubMed)
    Show all 5 references for 358214

  4. Human Polyclonal Retinoblastoma 1 Primary Antibody for EIA, IHC (p) - ABIN358211 : Lieman, Worley, Harbour: Loss of Rb-E2F repression results in caspase-8-mediated apoptosis through inactivation of focal adhesion kinase. in The Journal of biological chemistry 2005 (PubMed)
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  5. Human Polyclonal Retinoblastoma 1 Primary Antibody for DB, IHC (p) - ABIN389644 : Budde, Schneiderhan-Marra, Petersen, Brüne: Retinoblastoma susceptibility gene product pRB activates hypoxia-inducible factor-1 (HIF-1). in Oncogene 2005 (PubMed)
    Show all 2 references for 389644

  6. Human Monoclonal Retinoblastoma 1 Primary Antibody for FACS, IHC (fro) - ABIN180306 : Bártek, Vojt?sek, Grand, Gallimore, Lane: Cellular localization and T antigen binding of the retinoblastoma protein. in Oncogene 1992 (PubMed)
    Show all 2 references for 180306

  7. Human Polyclonal Retinoblastoma 1 Primary Antibody for FACS, IHC (p) - ABIN652516 : Connell-Crowley, Harper, Goodrich: Cyclin D1/Cdk4 regulates retinoblastoma protein-mediated cell cycle arrest by site-specific phosphorylation. in Molecular biology of the cell 1997 (PubMed)
    Show all 2 references for 652516

  8. Cow (Bovine) Polyclonal Retinoblastoma 1 Primary Antibody for WB - ABIN2777807 : Dasgupta, Sun, Wang, Fusaro, Betts, Padmanabhan, Sebti, Chellappan: Disruption of the Rb--Raf-1 interaction inhibits tumor growth and angiogenesis. in Molecular and cellular biology 2004 (PubMed)

更多抗Retinoblastoma 1的相互作用对抗体

Human Retinoblastoma 1 (RB1) interaction partners

  1. RB1 deficiency promotes cancer cell proliferation in part by enhancing mitochondrial function and identify tigecycline as a clinically approved drug for RB1-deficient triple negative breast cancer.

  2. this paper shows that patients with estrogen receptor (显示 ESR1 抗体) positive breast cancer expressing high Rb loss-of-function have significantly worse recurrence free survival compared to those with low Rb loss-of-function

  3. Combinatorial PX-866 and Raloxifene Decrease Rb Phosphorylation, Cyclin E2 (显示 CCNE2 抗体) Transcription, and Proliferation of MCF-7 Breast Cancer Cells

  4. TYROBP (显示 TYROBP 抗体) influences a batch of genes that are related to Alzheimer's disease; ZNF329 (显示 ZNF329 抗体) and RB1 significantly regulate those 'mesenchymal' gene expression signature genes for brain tumors. By merely leveraging gene expression data, Context Based Dependency Network (CBDN) can efficiently infer the existence of gene-gene interactions as well as their regulatory directions.

  5. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (显示 E2F1 抗体) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 (显示 CDK4 抗体) inhibitors in breast cancer for the development of more effective combination therapies.

  6. Here, we introduce a transcriptional signature to specifically track CDK2 (显示 CDK2 抗体) activity. It responds to genetic and chemical perturbations in the CDK (显示 CDK4 抗体)-RB-E2F (显示 E2F1 抗体) axis, correlates with mitotic rate in vitro and in vivo and reacts rapidly to changes in CDK2 (显示 CDK2 抗体) activity during cell cycle progression

  7. The N-Terminal phosphorylation of RB by p38 (显示 CRK 抗体) bypasses its inactivation by cyclin (显示 PCNA 抗体)-dependent kinases and prevents proliferation in cancer cells.

  8. Suggest frequent Rb1 deficiency as a possible driver molecular event in superficial acral fibromyxoma.

  9. The expression of Rb and MeCP2 (显示 MECP2 抗体) in patients with B-cell non-Hodgkin's lymphoma (B-NHL (显示 RTEL1 抗体)) showed that positive staining for MeCP2 (显示 MECP2 抗体) or Rb was significantly lower in B-NHL (显示 RTEL1 抗体) tumor tissues, and these changes were significantly and negatively correlated with the grade of B-NHL (显示 RTEL1 抗体).

  10. Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 (显示 CDK4 抗体) inhibitors releases Rb-mediated mTORC2 (显示 CRTC2 抗体) suppression. This, in turn, leads to elevated Akt (显示 AKT1 抗体) activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt (显示 AKT1 抗体) inhibitors.

Mouse (Murine) Retinoblastoma 1 (RB1) interaction partners

  1. Combined deletion of Vhl (显示 VHL 抗体), Trp53 (显示 TP53 抗体) and Rb1 specifically in renal epithelial cells in mice caused clear cell renal cell carcinoma (显示 MOK 抗体).

  2. The evidence has been presented that the retinoblastoma protein utilizes a cell-cycle-independent interaction with E2F1 (显示 E2F1 抗体) to recruit EZH2 (显示 EZH2 抗体) to diverse repeat sequences.

  3. The N-Terminal phosphorylation of RB by p38 (显示 CRK 抗体) bypasses its inactivation by cyclin (显示 PCNA 抗体)-dependent kinases and prevents proliferation in cancer cells.

  4. SUMO1 (显示 SUMO1 抗体) conjugation of RB and Lamin A/C (显示 LMNA 抗体) is modulated by the SUMO protease SENP1 (显示 SENP1 抗体) and that sumoylation of both proteins is required for their interaction.

  5. Inhibition of Rb phosphorylation by depleting cyclin D or using CDK4/6 (显示 CDK4 抗体) inhibitors releases Rb-mediated mTORC2 (显示 CRTC2 抗体) suppression. This, in turn, leads to elevated Akt (显示 AKT1 抗体) activation to confer resistance to chemotherapeutic drugs in Rb-proficient cells, which can be attenuated with Akt (显示 AKT1 抗体) inhibitors.

  6. The data presented here support a hypothesis in which RB1 and TP53 (显示 TP53 抗体) loss in prostate cancer derepresses Ezh2 (显示 EZH2 抗体) and Sox2 (显示 SOX2 抗体) factors, creating a stem cell-like epigenetic environment permissive for lineage plasticity

  7. systems-level control of cell cycle arrest by pRB (显示 PGR 抗体)-E2F (显示 E2F1 抗体) and p27 (显示 CDKN1B 抗体)-CDK (显示 CDK4 抗体) regulation, is reported.

  8. RB is necessary for the recruitment of the BRG1 (显示 SMARCA4 抗体) ATPase (显示 DNAH8 抗体) to DNA double-strand breaks, which stimulates DNA end resection and homologous recombination

  9. Findings implicate Rb1 in the regulation of the THO ribonucleoprotein complex.

  10. contribution of these precursors to the Rb(+/-) adipose phenotype is driven, at least in part, by interaction with BMP7 (显示 BMP7 抗体) pathway

Zebrafish Retinoblastoma 1 (RB1) interaction partners

  1. Our results indicate that Rb-Raf-1 (显示 RAF1 抗体) interaction plays an important role in spontaneous hair cell regeneration in zebrafish

  2. our analysis of zebrafish rb1 mutants reveals a previously unknown yet critical role for rb1 during retinotectal tract development and visual function.

  3. Zebrafish usp39 (显示 USP37 抗体) regulates embryonic pituitary homeostasis by targeting rb1 and e2f4 (显示 E2F4 抗体) expression, respectively, contributing to increased adenohypophyseal sensitivity to these altered cell cycle regulators

Retinoblastoma 1 (RB1) 抗原简介

Antigen Summary

The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Alternative names and synonyms associated with Retinoblastoma 1 (RB1)

  • retinoblastoma 1 (including osteosarcoma) (RB1) 抗体
  • retinoblastoma 1 (RB1) 抗体
  • Retinoblastoma-associated protein (rb) 抗体
  • retinoblastoma 1 (Rb1) 抗体
  • retinoblastoma 1 (rb1) 抗体
  • OSRC 抗体
  • P105-RB 抗体
  • PP110 抗体
  • pRb 抗体
  • Rb 抗体
  • Rb-1 抗体
  • RB1 抗体
  • RB11 抗体
  • zgc:154147 抗体

Protein level used designations for anti-Retinoblastoma 1 (RB1) 抗体

retinoblastoma 1 (including osteosarcoma) , retinoblastoma protein 1 , retinoblastoma-associated protein , Retinoblastoma-associated protein , retinoblastoma 1 , retinoblastoma-associated protein-like , retinoblastoma suspectibility protein , pp105 , retinoblastoma protein , Retinoblastoma 1 (including osteosarcoma) , pRb , rb , p104 , spc , retinoblastoma, susceptibility

GENE ID SPECIES
449604 Pan troglodytes
452715 Pan troglodytes
704871 Macaca mulatta
100217687 Taeniopygia guttata
100380330 Salmo salar
100397928 Callithrix jacchus
5925 Homo sapiens
19645 Mus musculus
476915 Canis lupus familiaris
100057080 Equus caballus
24708 Rattus norvegicus
386582 Gallus gallus
777733 Danio rerio
534712 Bos taurus
100716297 Cavia porcellus
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