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USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. 再加上，我们可以发USP14 抗体 (88) 和 USP14 试剂盒 (5)和数多这个蛋白质的别的产品。
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Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma
our report demonstrates significant value in targeting USP14/UCHL5 (显示 UCHL5 蛋白) with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation
USP14 promotes prostate cancer progression.
without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.
USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1 (显示 BECN1 蛋白)
USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.
USP14 participates in CAM-DR of MM through acting as a bridge between Bcl-xl (显示 BCL2L1 蛋白) apoptotic pathway and Wnt (显示 WNT2 蛋白)-signaling pathways and may be represented as a good candidate for pursuing clinical trials in MM.
Results show that USP14 mRNA is overexpressed in hepatocellular carcinoma (HCC) tissues and inversely correlates with miR-4782-3p level which binds to USP14 3'UTR to regulate its expression.
Results found USP14 amplification and overexpression in many different cancers. Its overexpression in low-expression cell lines promoted cell proliferation and migration, whereas its downregulation suppressed tumor cell proliferation, increased apoptosis rate, and decreased cell migration and invasion suggesting an oncogenic role in various types of cancer.
Increased USP14 expression in patients with breast cancer was associated with a poorer prognosis.
USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.
Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.
USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.
Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.
Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.
miR-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation.
overexpression of HA-USP14 increased TNFalpha (显示 TNF 蛋白)
Oxidative stress increasd USP14 expression, and beta-carotene dose-dependently inhibited increased expression in mouse skeletal muscle myotubes.
ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 (显示 UCHL5 蛋白) to activate ATP hydrolysis and enhance their own destruction
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme 14
, tRNA-guanine transglycosylase, 60-kD subunit
, ubiquitin carboxyl-terminal hydrolase 14
, ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
, ubiquitin thioesterase 14
, ubiquitin thiolesterase 14
, ubiquitin-specific processing protease 14
, ubiquitin-specific-processing protease 14
, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
, ubiquitin domain-containing protein
, dUB-type TGT for deubiquitinating enzyme
, ubiquitin specific protease 14
, universal stress protein
, queuine tRNA-ribosyltransferase
, ubiquitin carboxyl-terminal hydrolase 14-like