Ubiquitin Specific Peptidase 14 蛋白 (USP14)

USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. 再加上,我们可以发USP14 抗体 (88)USP14 试剂盒 (5)和数多这个蛋白质的别的产品。

列出全部蛋白 基因 基因ID UniProt
USP14 9097 P54578
USP14 59025 Q9JMA1
大鼠 USP14 USP14 291796  
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Showing 10 out of 15 products:

产品编号 Origin 资源 标记 图像 规格 供应商 交付 价格 详细
Insect Cells His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells 小鼠 His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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大肠杆菌(E. Coli) His tag 100 μg Log in to see 15至19个工作日
$319.00
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大肠杆菌(E. Coli) His tag Validation with Western Blot 10 μg Log in to see 12至15个工作日
$460.85
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大肠杆菌(E. Coli) His tag   50 μg Log in to see 4 Days
$330.00
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HEK-293 Cells Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10至12个工作日
$785.40
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大肠杆菌(E. Coli) His tag   10 μg Log in to see 15至16个工作日
$212.50
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小麦胚 GST tag 10 μg Log in to see 11至12个工作日
$405.71
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酵母菌 Caenorhabditis elegans His tag   1 mg Log in to see 60至71个工作日
$3,384.33
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酵母菌 Pan troglodytes His tag   1 mg Log in to see 60至71个工作日
$3,397.17
详细

USP14 蛋白 by Origin and Source

Origin 在表达 标记
Human , , ,
, ,
Mouse (Murine)

更多Ubiquitin Specific Peptidase 14 (USP14)互动伙伴

Human Ubiquitin Specific Peptidase 14 (USP14) interaction partners

  1. Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma

  2. our report demonstrates significant value in targeting USP14/UCHL5 (显示 UCHL5 蛋白) with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation

  3. USP14 promotes prostate cancer progression.

  4. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  5. USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1 (显示 BECN1 蛋白)

  6. USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.

  7. USP14 participates in CAM-DR of MM through acting as a bridge between Bcl-xl (显示 BCL2L1 蛋白) apoptotic pathway and Wnt (显示 WNT2 蛋白)-signaling pathways and may be represented as a good candidate for pursuing clinical trials in MM.

  8. Results show that USP14 mRNA is overexpressed in hepatocellular carcinoma (HCC) tissues and inversely correlates with miR-4782-3p level which binds to USP14 3'UTR to regulate its expression.

  9. Results found USP14 amplification and overexpression in many different cancers. Its overexpression in low-expression cell lines promoted cell proliferation and migration, whereas its downregulation suppressed tumor cell proliferation, increased apoptosis rate, and decreased cell migration and invasion suggesting an oncogenic role in various types of cancer.

  10. Increased USP14 expression in patients with breast cancer was associated with a poorer prognosis.

Mouse (Murine) Ubiquitin Specific Peptidase 14 (USP14) interaction partners

  1. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  2. USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.

  3. Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.

  4. USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.

  5. Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.

  6. Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.

  7. miR-124 promotes neuronal survival under ischemic conditions via Usp14-dependent REST degradation.

  8. overexpression of HA-USP14 increased TNFalpha (显示 TNF 蛋白)

  9. Oxidative stress increasd USP14 expression, and beta-carotene dose-dependently inhibited increased expression in mouse skeletal muscle myotubes.

  10. ubiquitinated loosely folded proteins, after becoming bound to the 26 S, interact with Ubp6/Usp14 or Uch37 (显示 UCHL5 蛋白) to activate ATP hydrolysis and enhance their own destruction

蛋白简介USP14

蛋白简介

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Gene names and symbols associated with USP14

  • ubiquitin specific peptidase 14 (USP14)
  • peptidase C19 family protein (usp14)
  • ubiquitin specific peptidase 14 (Usp14)
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (usp14)
  • ubiquitin specific protease 14 (Bm1_28765)
  • ubiquitin specific peptidase 14 S homeolog (usp14.S)
  • ubiquitin specific peptidase 14 (usp14)
  • universal stress protein (RR_RS06480)
  • Ubiquitin carboxyl-terminal hydrolase 14 (usp-14)
  • 2610005K12Rik 蛋白
  • 2610037B11Rik 蛋白
  • AW107924 蛋白
  • ax 蛋白
  • C78769 蛋白
  • DDBDRAFT_0202821 蛋白
  • DDBDRAFT_0237695 蛋白
  • DDB_0202821 蛋白
  • DDB_0237695 蛋白
  • MGC69343 蛋白
  • MGC81945 蛋白
  • tgt 蛋白
  • USP14 蛋白
  • wu:fk63d09 蛋白
  • zgc:55949 蛋白

Protein level used designations for USP14

deubiquitinating enzyme 14 , tRNA-guanine transglycosylase, 60-kD subunit , ubiquitin carboxyl-terminal hydrolase 14 , ubiquitin specific protease 14 (tRNA-guanine transglycosylase) , ubiquitin thioesterase 14 , ubiquitin thiolesterase 14 , ubiquitin-specific processing protease 14 , ubiquitin-specific-processing protease 14 , ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) , ubiquitin domain-containing protein , ataxia , dUB-type TGT for deubiquitinating enzyme , ubiquitin specific protease 14 , universal stress protein , queuine tRNA-ribosyltransferase , ubiquitin carboxyl-terminal hydrolase 14-like

GENE ID SPECIES
9097 Homo sapiens
100090009 Ornithorhynchus anatinus
8617881 Dictyostelium discoideum AX4
59025 Mus musculus
291796 Rattus norvegicus
335736 Danio rerio
455325 Pan troglodytes
505106 Bos taurus
6100653 Brugia malayi
421063 Gallus gallus
447733 Xenopus laevis
448110 Xenopus (Silurana) tropicalis
480182 Canis lupus familiaris
698087 Macaca mulatta
3130489 Haloarcula marismortui ATCC 43049
100009078 Oryctolagus cuniculus
100013535 Monodelphis domestica
100394297 Callithrix jacchus
100473541 Ailuropoda melanoleuca
100586916 Nomascus leucogenys
175105 Caenorhabditis elegans
USP14 蛋白 (USP14) 精选生产商
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