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USP14 产品

(Ubiquitin Specific Peptidase 14 (USP14))

Categories

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008].

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Featured USP14 Categories

USP14 抗体

High quality antibodies with extensive validation data.

USP14 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

USP14 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended USP14 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (1)
  • (8)
Cat. No. ABIN563939
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (5)
Cat. No. ABIN563938
Quantity 50 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
Cat. No. ABIN7174258
Quantity 100 μg
Datasheet Datasheet

Recommended USP14 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960351
Quantity 96 tests
Datasheet Datasheet

Recommended USP14 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324754
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324752
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096214
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our USP14 Products

Hyrskyluoto, Bruelle, Lundh, Do, Kivinen, Rappou, Reijonen, Waltimo, Petersén, Lindholm, Korhonen: "Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1?." in: Human molecular genetics, Vol. 23, Issue 22, pp. 5928-39, (2014) (PubMed).

Davila, Froeling, Tan, Bonnard, Boland, Snippe, Hibberd, Seielstad: "New genetic associations detected in a host response study to hepatitis B vaccine." in: Genes and immunity, Vol. 11, Issue 3, pp. 232-8, (2010) (PubMed).

Carrascal, Ovelleiro, Casas, Gay, Abian: "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment." in: Journal of proteome research, Vol. 7, Issue 12, pp. 5167-76, (2009) (PubMed).

Chen, Qin, Li, Walters, Wilson, Mei, Wilson: "The proteasome-associated deubiquitinating enzyme Usp14 is essential for the maintenance of synaptic ubiquitin levels and the development of neuromuscular junctions." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 29, Issue 35, pp. 10909-19, (2009) (PubMed).

Nagai, Kadowaki, Maruyama, Takeda, Nishitoh, Ichijo: "USP14 inhibits ER-associated degradation via interaction with IRE1alpha." in: Biochemical and biophysical research communications, Vol. 379, Issue 4, pp. 995-1000, (2009) (PubMed).

Mines, Goodwin, Limbird, Cui, Fan: "Deubiquitination of CXCR4 by USP14 is critical for both CXCL12-induced CXCR4 degradation and chemotaxis but not ERK ativation." in: The Journal of biological chemistry, Vol. 284, Issue 9, pp. 5742-52, (2009) (PubMed).

Koulich, Li, DeMartino: "Relative structural and functional roles of multiple deubiquitylating proteins associated with mammalian 26S proteasome." in: Molecular biology of the cell, Vol. 19, Issue 3, pp. 1072-82, (2008) (PubMed).

Reuter, Medhurst, Waisfisz, Zhi, Herterich, Hoehn, Gross, Joenje, Hoatlin, Mathew, Huber: "Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport." in: Experimental cell research, Vol. 289, Issue 2, pp. 211-21, (2003) (PubMed).

Puente, Sánchez, Overall, López-Otín: "Human and mouse proteases: a comparative genomic approach." in: Nature reviews. Genetics, Vol. 4, Issue 7, pp. 544-58, (2003) (PubMed).

Synonyms and alternative names related to USP14

ubiquitin specific peptidase 14 (USP14), peptidase C19 family protein (usp14), ubiquitin specific peptidase 14 (Usp14), ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (usp14), ubiquitin specific protease 14 (Bm1_28765), ubiquitin specific peptidase 14 S homeolog (usp14.S), ubiquitin specific peptidase 14 (usp14), universal stress protein (RR_RS06480), Ubiquitin carboxyl-terminal hydrolase 14 (usp-14), 2610005K12Rik, 2610037B11Rik, AW107924, ax, C78769, DDBDRAFT_0202821, DDBDRAFT_0237695, DDB_0202821, DDB_0237695, MGC69343, MGC81945, TGT, tgt, USP14, wu:fk63d09, zgc:55949

Protein level used designations for USP14

  • deubiquitinating enzyme 14
  • tRNA-guanine transglycosylase, 60-kD subunit
  • ubiquitin carboxyl-terminal hydrolase 14
  • ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
  • ubiquitin thioesterase 14
  • ubiquitin thiolesterase 14
  • ubiquitin-specific processing protease 14
  • ubiquitin-specific-processing protease 14
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
  • ubiquitin domain-containing protein
  • ataxia
  • dUB-type TGT for deubiquitinating enzyme
  • ubiquitin specific protease 14
  • universal stress protein
  • queuine tRNA-ribosyltransferase
  • ubiquitin carboxyl-terminal hydrolase 14-like
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