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NAMPT encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. 再加上，我们可以发NAMPT 抗体 (365) 和 NAMPT 试剂盒 (123)和数多这个蛋白质的别的产品。
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Human NAMPT Protein expressed in Escherichia coli (E. coli) - ABIN1344091
Yonezawa, Haga, Kobayashi, Takahashi, Obara: Visfatin is present in bovine mammary epithelial cells, lactating mammary gland and milk, and its expression is regulated by cAMP pathway. in FEBS letters 2006
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Human NAMPT Protein expressed in Escherichia coli (E. coli) - ABIN413884
Šenolt, Kuklová, Cerezo, Hulejová, Filková, Bošanská, Pecha, Pavelka, Haluzík, Vencovský: Adipokine profile is modulated in subcutaneous adipose tissue by TNFα inhibitors in patients with rheumatoid arthritis. in Annals of the rheumatic diseases 2011
Show all 2 Pubmed References
Mouse (Murine) NAMPT Protein expressed in Escherichia coli (E. coli) - ABIN1344090
Brown, Onyango, Ramanjaneya, Conner, Patel, Dunmore, Randeva: Visfatin regulates insulin secretion, insulin receptor signalling and mRNA expression of diabetes-related genes in mouse pancreatic beta-cells. in Journal of molecular endocrinology 2010
Rat (Rattus) NAMPT Protein expressed in HEK-293 Cells - ABIN1344283
Spinnler, Gorski, Stolz, Schuster, Garten, Beck-Sickinger, Engelse, de Koning, Körner, Kiess, Maedler: The adipocytokine Nampt and its product NMN have no effect on beta-cell survival but potentiate glucose stimulated insulin secretion. in PLoS ONE 2013
Mouse (Murine) NAMPT Protein expressed in Escherichia coli (E. coli) - ABIN413887
Kanda, Hau, Tada, Tatsuta, Sato, Watanabe: Visfatin enhances CXCL8, CXCL10, and CCL20 production in human keratinocytes. in Endocrinology 2011
In summary, NAMPT is produced in human spermatozoa in a maturation-dependent manner.
Non-surgical periodontal treatment resulted in a significant reduction in gingival crevicular fluid and serum visfatin levels. Furthermore, visfatin levels increased with inflammation and decreased following periodontal treatment. Our findings suggest that visfatin is an inflammatory biomarker of periodontal disease
Accordingly, our results demonstrated that NAMPT is a prognostic marker in melanoma, and the identificationofNAMPT-E2F2 (显示 E2F2 蛋白)-SIRT1 (显示 SIRT1 蛋白) pathway establishes another link between NAMPT and apoptosis events in melanoma, with therapeutic implications for this deadly cancer.
systemic circulating NAMPT levels were closely associated with NAMPT release from corresponding cultured PBMCs. In conclusion, NAMPT is selectively increased in states of acute but not chronic inflammation in children
It focusing on NAMPT immunometabolic function as a metabokine, NAMPT secretion, NAMPT mechanism of action and possible roles in the cancer micro-environment.
Authors show the gene encoding nicotinic acid phosphoribosyltransferase (显示 NAPRT1 蛋白) (NAPRT), a second NAD(+)-producing enzyme, is amplified and overexpressed in a subset of common types of cancer, including ovarian cancer.
This study shows that expression of SDF-1alpha, eNOS (显示 NOS3 蛋白) and VEGF (显示 VEGFA 蛋白) were significantly higher in uterine leiomyoma than myometrium with a different expression pattern according to the size of uterine leiomyoma. However, expressions of visfatin and leptin (显示 LEP 蛋白) had no significant differences between the two groups.
Results indicate that increased serum visfatin levels are associated with poor prognosis of hepatocellular carcinoma (HCC (显示 FAM126A 蛋白)), and visfatin may be a potential therapeutic target of HCC (显示 FAM126A 蛋白).
Nampt expression is a reliable marker of progression in cervical dysplasia and squamous cell carcinoma.
Visfatin increases the nuclear translocation of Akt (显示 AKT1 蛋白) and its binding with ABCC1 (显示 ABCC1 蛋白). These data showed that visfatin can decrease doxorubicin sensitivity of Non-small-cell lung cancer cells via activation of Akt (显示 AKT1 蛋白)/MRP1 (显示 MDM4 蛋白).
NAMPT-mediated NAD(+) biosynthesis in adipocytes regulates adipose tissue function and multi-organ insulin (显示 INS 蛋白) sensitivity in mice.
NAMPT-mediated NAD(+) biosynthesis is essential for vision in mice.
NAMPT is involved in key basic cellular functions.
role of Nampt in regulating osteoblast differentiation in primary mouse bone marrow-derived mesenchymal stem cells (BM-MSCs); Nampt expression was progressively elevated during BM-MSCs osteogenic differentiation
The results suggest that NCOA6 (显示 NCOA6 蛋白) stimulates insulin (显示 INS 蛋白) secretion, at least partially, by modulating Nampt expression in pancreatic beta-cells.
the protein expression levels of TIMP-2 (显示 TIMP2 蛋白) and PBEF in cloned placentae, were examined.
NAMPT inhibited endothelial progenitor cell senescence through an SIRT1 (显示 SIRT1 蛋白) AS lncRNA/miR (显示 MLXIP 蛋白)-22/SIRT1 (显示 SIRT1 蛋白) pathway
Visfatin upregulated CD36 (显示 CD36 蛋白) and SRA (显示 MSR1 蛋白) expression and downregulated ABCA1 (显示 ABCA1 蛋白) and ABCG1 (显示 ABCG1 蛋白) expression, subsequently increased ox-LDL uptake and decreased cholesterol efflux, and finally promoted foam cell formation via the PI3K- and ERK (显示 EPHB2 蛋白)-dependent pathways.
results support a novel, important role for Nampt-mediated NAD(+) biosynthesis in long-term depression and in the function of GluN2B (显示 GRIN2B 蛋白)-containing NMDARs
extracellular NAMPT can be actively released by melanoma cells in vitro.
In a wild boar x Meishan F2 family nicotinamide phosphoribosyltransferase nicotinamide phosphoribosyltransferase SNP 669T>C was associated with muscling, fat deposition, growth and fattening, meat quality and other traits.
cloning and characterization of porcine visfatin and its three alternate splicing variants is reported; sequence analysis indicated that variant 1 is the predominant form among species.
The porcine visfatin gene cannot be considered as a marker of fat accumulation since the highest visfatin expression levels were associated with the leaner (显示 CACNA1A 蛋白) animals.
Exposure to follicular fluid transiently increased the transcript levels of IL8 (显示 IL8 蛋白) and PTGS2 (显示 PTGS2 蛋白), and decreased the expression of SOD2 (显示 SOD2 蛋白), GPX3 (显示 GPX3 蛋白), DAB2 (显示 DAB2 蛋白), and NR3C1 (显示 NR3C1 蛋白). TNF (显示 TNF 蛋白) and IL6 (显示 IL6 蛋白) levels were also decreased while those of NAMPT were unaffected.
the presence of 35bp-insertion in visfatin gene may influence the birth weight and bodyweight in 6-month-old cows.
These results indicate that mammary epithelial cells express the visfatin protein and secrete them into the milk.
This gene encodes a protein that catalyzes the condensation of nicotinamide with 5-phosphoribosyl-1-pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. The protein belongs to the nicotinic acid phosphoribosyltransferase (NAPRTase) family and is thought to be involved in many important biological processes, including metabolism, stress response and aging. This gene has a pseudogene on chromosome 10.
, pre-B cell-enhancing factor
, pre-B-cell colony enhancing factor 1
, pre-B-cell colony-enhancing factor 1
, pre-B-cell colony-enhancing factor 1 homolog
, Nicotinamide phosphoribosyltransferase
, nicotinamide phosphoribosyltransferase
, pre-B-cell colony-enhancing factor-like protein