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MLF1 encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. 再加上，我们可以发MLF1 蛋白 (8) 和 MLF1 试剂盒 (3)和数多这个蛋白质的别的产品。
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Human Polyclonal MLF1 Primary Antibody for WB - ABIN517941
Hoh, Stowe, Turk, Stearns: Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. in PLoS ONE 2013
Human Polyclonal MLF1 Primary Antibody for WB - ABIN2785560
Li, Wu, Jiang, Liu, Wu, Inagaki, Izawa, Mizisin, Engvall, Shelton: Non-pathogenic protein aggregates in skeletal muscle in MLF1 transgenic mice. in Journal of the neurological sciences 2007
Show all 2 Pubmed References
Mutation in HTT (显示 HTT 抗体) causes Huntington's disease (HD); aggregates of mutated HTT (显示 HTT 抗体) cause apoptosis in neurons of HD patients. Data suggest that both MLF1 and MLF2 preferentially interact with mutated N-terminal HTT (显示 HTT 抗体); MLF1/MLF2 reduce number of neurons (Neuro2A cell line) containing mutant HTT (显示 HTT 抗体) aggregates and subsequent apoptosis. (HTT (显示 HTT 抗体) = Huntingtin (显示 HTT 抗体) protein; MLF = myeloid leukemia (显示 BCL11A 抗体) factor)
The data indicate that MLF1 serves as a proapoptotic antagonist that interacts with the HAX1 (显示 HAX1 抗体)/HtrA2-OMI (显示 HTRA2 抗体)/PARL (显示 PARL 抗体) (HOP (显示 STIP1 抗体)) mitochondrial complex to modulate cell survival.
SNP associated with neuroblastoma (显示 ARHGEF16 抗体) resides upstream of the MLF1. Gene silencing of MLF1 in neuroblastoma (显示 ARHGEF16 抗体) cells results in significant growth inhibition.
Data indicte that acute myeloid leukemia (显示 BCL11A 抗体) (AML (显示 RUNX1 抗体)) with NPM1 (显示 NPM1 抗体)-MLF1 and AML (显示 RUNX1 抗体) with NPM1 (显示 NPM1 抗体) mutations showed similar immunophenotypical and molecular features, including gene mutation patterns and gene expression profiling (GEP (显示 GNA12 抗体)).
The subcellular localization of full-length human MLF1 is 14-3-3epsilon-independent.
changes in the subcellular localization of NPM (显示 NPM1 抗体), due to alterations in the relative abundance of NPM (显示 NPM1 抗体) and NPM (显示 NPM1 抗体)-MLF1 proteins, may contribute to the enhanced myeloid progenitor activity of Npm (显示 NPM1 抗体) +/- cells
Data present the high-resolution crystal structure of this binding motif [MLF1(29-42)pSer34] in complex with 14-3-3epsilon and analyse the interaction with isothermal titration calorimetry.
MLF1 gene rearrangement is associated with acute myeloid leukemia (显示 BCL11A 抗体).
phosphorylation of 14-3-3 (显示 YWHAQ 抗体) binding site by MADM (显示 ADAM10 抗体)
These findings suggest that an NPM (显示 NPM1 抗体)/MLF1 fusion is the primary molecular abnormality in t(3;5) MDS (显示 PAFAH1B1 抗体) and AML (显示 RUNX1 抗体) with multilineage dysplasia, and that cases with NPM (显示 NPM1 抗体)/MLF1 may be clinically distinct from other MDS (显示 PAFAH1B1 抗体)-associated disease
Ectopically expressed MLF1 could be responsible for the pathological apoptosis in early myelodysplastic syndrome (MDS (显示 MECOM 抗体)) patients.
Mlf1 translocates between nucleus and cytoplasm, associates with a novel hnRNP, and influences gene expression
shuttling of MLF1 is critical for the regulation of cell proliferation and a disturbance in the shuttling balance increases the cell's susceptibility to oncogenic transformation
This gene encodes an oncoprotein which is thought to play a role in the phenotypic determination of hemopoetic cells. Translocations between this gene and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
myeloid leukemia factor 1
, myelodysplasia-myeloid leukemia factor 1
, hematopoietic lineage switch 7