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MLF1 抗体 (pThr78)

MLF1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN129686
发货至: 中国
  • 抗原 See all MLF1 抗体
    MLF1 (Myeloid Leukemia Factor 1 (MLF1))
    抗原表位
    • 13
    • 9
    • 8
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr78
    适用
    • 66
    • 40
    • 20
    • 1
    • 1
    宿主
    • 63
    • 5
    克隆类型
    • 65
    • 3
    多克隆
    标记
    • 39
    • 4
    • 4
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This MLF1 antibody is un-conjugated
    应用范围
    • 60
    • 27
    • 25
    • 19
    • 13
    • 9
    • 7
    • 4
    • 3
    • 3
    • 2
    Western Blotting (WB), ELISA
    交叉反应
    犬, 绵羊, Chimpanzee
    产品特性
    Concentration Definition: by UV absorbance at 280 nm
    免疫原
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids surrounding Thr78 of human MLF1IP protein.  The immunogen peptide is phosphorylated at Thr78.
    亚型
    IgG
    Top Product
    Discover our top product MLF1 Primary Antibody
  • 应用备注
    This affinity purified antibody has been tested for use in ELISA, western blotting and immunocytochemistry.  Specific conditions for reactivity should be optimized by the end user.  Expect a band approximately 65 kDa in size corresponding to MLF1IP protein by western blotting in the appropriately stimulated tissue, cell lysate or extract.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1.06 mg/mL
    缓冲液
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    储存液
    Sodium azide
    注意事项
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
  • Kang, Park, Yu, Soung, Yun, Bang, Seong, Yu, Garfield, Veenstra, Lee: "Self-regulated Plk1 recruitment to kinetochores by the Plk1-PBIP1 interaction is critical for proper chromosome segregation." in: Molecular cell, Vol. 24, Issue 3, pp. 409-22, (2006) (PubMed).

  • 抗原
    MLF1 (Myeloid Leukemia Factor 1 (MLF1))
    别名
    Mlf1 (MLF1 产品)
    别名
    MLF1 antibody, HLS7 antibody, myeloid leukemia factor 1 antibody, myeloid leukemia factor 1 L homeolog antibody, MLF1 antibody, mlf1.L antibody, mlf1 antibody, Mlf1 antibody
    背景
    This antibody is designed, produced, and is suitable for Cancer, Immunology and Nuclear Signaling research. Myeloid leukemia factor-1 (MLF1) Interacting Protein (also known as PBIP1, MLF1IP1, KLIP1 or KSHV latent nuclear antigen interacting protein 1) is a novel polo-like kinase 1 (Plk1) substrate.  Plk1 phosphorylation of MLF1IP induces ubiquitination and degradation of MLF1IP prior to the metaphase/ anaphase transition.  Several Plk1-dependent phosphorylation sites have been identified on MLF1IP by mass spectrometry.  Mutations of these sites stabilize MLF1IP and inhibit mitotic progression.  Subsequent in vitro and in vivo MLF1IP phosphorylation and stability assays have revealed that phosphorylation of Thr78 is critical for triggering Plk1-dependent MLF1IP degradation.  Expression of a non-degradable Thr78Ala mutant was sufficient to induce a mitotic block.  Timely phosphorylation of MLF1IP on Thr78 by Plk1 is critical for eliminating the MLF1IP-imposed mitotic block prior to anaphase onset.  MLF1IP is speculated to be a novel tumor suppressor,
    Synonyms: FLJ23468 antibody, HHV8 LNAIP1 antibody, ICEN24 antibody, Kaposi Sarcoma Herpesvirus latent nuclear antigen interacting protein 1 antibody
    基因ID
    79682, 38016935
    UniProt
    Q71F23
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