XRCC5 抗体
(X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 5 (Double-Strand-Break Rejoining) (XRCC5))
The protein encoded by this gene is the 80-kilodalton subunit of the Ku heterodimer protein which is also known as ATP-dependant DNA helicase II or DNA repair protein XRCC5. Ku is the DNA-binding component of the DNA-dependent protein kinase, and it functions together with the DNA ligase IV-XRCC4 complex in the repair of DNA double-strand break by non-homologous end joining and the completion of V(D)J recombination events. This gene functionally complements Chinese hamster xrs-6, a mutant defective in DNA double-strand break repair and in ability to undergo V(D)J recombination. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008].
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Latest Publications for our XRCC5 抗体
: "Downregulation of TMPRSS4 Enhances Triple-Negative Breast Cancer Cell Radiosensitivity Through Cell Cycle and Cell Apoptosis Process Impairment." in: Asian Pacific journal of cancer prevention : APJCP, Vol. 20, Issue 12, pp. 3679-3687, (2020) (PubMed).: "Histone H3K27 methylation modulates the dynamics of FANCD2 on chromatin to facilitate NHEJ and genome stability." in: Journal of cell science, Vol. 131, Issue 12, (2018) (PubMed).
: "BCL2-overexpressing prostate cancer cells rely on PARP1-dependent end-joining and are sensitive to combined PARP inhibitor and radiation therapy." in: Cancer letters, Vol. 423, pp. 60-70, (2018) (PubMed).
: "Impaired DNA double-strand break repair contributes to the age-associated rise of genomic instability in humans." in: Cell death and differentiation, Vol. 23, Issue 11, pp. 1765-1777, (2017) (PubMed).
: "Influence of XRCC4 expression in esophageal cancer cells on the response to radiotherapy." in: Medical molecular morphology, Vol. 50, Issue 1, pp. 25-33, (2016) (PubMed).
: "Expression of Ku70 predicts results of radiotherapy in prostate cancer." in: Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], Vol. 193, Issue 1, pp. 29-37, (2016) (PubMed).
: "Serum anti-Ku86 is a potential biomarker for early detection of hepatitis C virus-related hepatocellular carcinoma." in: Biochemical and biophysical research communications, Vol. 421, Issue 4, pp. 837-43, (2012) (PubMed).
: "Ku proteins interact with activator protein-2 transcription factors and contribute to ERBB2 overexpression in breast cancer cell lines." in: Breast cancer research : BCR, Vol. 11, Issue 6, pp. R83, (2010) (PubMed).
: "The cytoprotective drug amifostine modifies both expression and activity of the pro-angiogenic factor VEGF-A." in: BMC medicine, Vol. 8, pp. 19, (2010) (PubMed).
: "Androgen modulation of coregulator expression in prostate cancer cells." in: Molecular endocrinology (Baltimore, Md.), Vol. 23, Issue 4, pp. 572-83, (2009) (PubMed).
Aliases for XRCC5 抗体
X-ray repair cross complementing 5 (XRCC5) 抗体X-ray repair complementing defective repair in Chinese hamster cells 5 (Xrcc5) 抗体
X-ray repair cross complementing 5 (Xrcc5) 抗体
X-ray repair complementing defective repair in Chinese hamster cells 5 L homeolog (xrcc5.L) 抗体
AI314015 抗体
KARP-1 抗体
KARP1 抗体
Ku80 抗体
KU80 抗体
Ku86 抗体
KUB2 抗体
Kup80 抗体
NFIV 抗体
XRCC5 抗体
xrcc5-a 抗体
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