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|抗原||Calcium/calmodulin-Dependent Protein Kinase (CaM Kinase) II beta (CAMK2B) 抗体|
|适用||人, 小鼠, 大鼠 其他选择|
|标记||This CAMK2B antibody is un-conjugated 其他选择|
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
|Supplier||Log in to see|
CAMK2B抗体详情CAMK2B目标详情 使用细节 贮存及处理 图像
|特异性||This antibody detects endogenous levels of CaMKIIbeta/gamma/delta protein. (region surrounding Ser280)|
Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.
|纯度||> 95 % by SDS-PAGE|
CAMK2B目标详情CAMK2B抗体详情 使用细节 贮存及处理 图像 回页首
|别名||CAMK2B (CAMK2B Antibody 摘要)|
|背景||The Ca2+/calmodulin-dependent protein kinases (CaM kinases) comprise a structurally related subfamily of serine/threonine kinases which include CaMKI, CaMKII and CaMKIV. CaMKII is an ubiquitously expressed serine/threonine protein kinase that is activated by Ca2+ and calmodulin (CaM) and has been implicated in regulation of the cell cycle and transcription. There are four CaMKII isozymes, designated alpha, beta, gamma and delta, which may or may not be coexpressed in the same tissue type. CaMKIV is stimulated by Ca2+ and CaM but also requires phosphorylation by a CaMK for full activation. Stimulation of the T cell receptor CD3 signaling complex with an anti-CD3 monoclonal antibody leads to a 10-40-fold increase in CaMKIV activity. An additional kinase, CaMKK, functions to activate CaMKI through the specific phosphorylation of the regulatory threonine residue at position 177.Synonyms: CAM2, CAMKB, CAMKIIb, CaM kinase II subunit beta, CaM-kinase II beta chain, CaMK-II subunit beta, Calcium/calmodulin-dependent protein kinase type II beta chain|
|分子量||approx. 50, 65 kDa|
|途径||WNT signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling, Smooth Muscle Cell Migration, Regulation of long-term Neuronal Synaptic Plasticity|
使用细节CAMK2B抗体详情 CAMK2B目标详情 贮存及处理 图像 回页首
Western Blot: 1/500 - 1/1000. Immunohistochemistry: 1/50 - 1/200.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
贮存及处理CAMK2B抗体详情 CAMK2B目标详情 使用细节 图像 回页首
|缓冲液||Phosphate buffered saline (PBS), pH 7.2., 0.05 % sodium azide|
|注意事项||This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|注意事项||Avoid repeated freezing and thawing.|
|储存条件||4 °C/-20 °C|
|储存方法||Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.|
图像CAMK2B抗体详情 CAMK2B目标详情 使用细节 贮存及处理 回页首