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UMPS 产品

(Uridine Monophosphate Synthetase (UMPS))

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This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010].

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Featured UMPS Categories

UMPS 抗体

High quality antibodies with extensive validation data.

UMPS 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended UMPS 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet

Application WB, IHC
Validations
  • (1)
  • (6)
Cat. No. ABIN2783243
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA, IF
Validations
  • (1)
  • (4)
Cat. No. ABIN521259
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (3)
Cat. No. ABIN7175108
Quantity 100 μg
Datasheet Datasheet

Recommended UMPS 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324639
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1324637
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3075158
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our UMPS Products

Griffith, Mwenifumbo, Cheung, Paul, Pugh, Tang, Chittaranjan, Morin, Asano, Ally, Miao, Lee, Chan, Taylor, Severson, Hou, Griffith, Cheng, Novik, Moore, Luk, Owen, Brown, Morin, Gill, Tai, Marra: "Novel mRNA isoforms and mutations of uridine monophosphate synthetase and 5-fluorouracil resistance in colorectal cancer." in: The pharmacogenomics journal, Vol. 13, Issue 2, pp. 148-58, (2013) (PubMed).

Bardeleben, Sharma, Reeve, Bassilian, Frost, Hoang, Shi, Lichtenstein: "Metabolomics identifies pyrimidine starvation as the mechanism of 5-aminoimidazole-4-carboxamide-1-β-riboside-induced apoptosis in multiple myeloma cells." in: Molecular cancer therapeutics, Vol. 12, Issue 7, pp. 1310-21, (2013) (PubMed).

Koopman, Venderbosch, van Tinteren, Ligtenberg, Nagtegaal, Van Krieken, Punt: "Predictive and prognostic markers for the outcome of chemotherapy in advanced colorectal cancer, a retrospective analysis of the phase III randomised CAIRO study." in: European journal of cancer (Oxford, England : 1990), Vol. 45, Issue 11, pp. 1999-2006, (2009) (PubMed).

Ishikawa, Kondo, Yamaguchi, Sakamoto, Fujisawa: "Effect of varicocelectomy on patients with unobstructive azoospermia and severe oligospermia." in: BJU international, Vol. 101, Issue 2, pp. 216-8, (2008) (PubMed).

Synonyms and alternative names related to UMPS

Orotidine 5'-phosphate decarboxylase (umps-1), uridine monophosphate synthetase (umps), uridine monophosphate synthetase L homeolog (umps.L), uridine monophosphate synthetase (UMPS), uridine 5'-monophosphate synthase (LOC100556619), uridine monophosphate synthetase (Umps), 1700095D23Rik, AA408257, AL033308, BB164745, OPRT, UMPS, zgc:55702, zgc:55723

Protein level used designations for UMPS

  • Uridine MonoPhosphate Synthetase family member (umps-1)
  • uridine 5'-monophosphate synthase
  • uridine monophosphate synthetase
  • uridine monophosphate synthase
  • uridine monophosphate synthetase (orotate phosphoribosyl transferase and orotidine-5'-decarboxylase)
  • OMPdecase
  • OPRTase
  • UMP synthase
  • orotate phosphoribosyltransferase
  • orotidine 5'-phosphate decarboxylase
  • orotate phosphoribosyl transferase and orotidine-5'-decarboxylase
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