UIMC1 产品
(Ubiquitin Interaction Motif Containing 1 (UIMC1))
Categories
Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B\; the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly Act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1 (By similarity).
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UIMC1 抗体
High quality antibodies with extensive validation data.
UIMC1 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
UIMC1 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
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Latest Publications for our UIMC1 Products
: "The Ubiquitin E3/E4 Ligase UBE4A Adjusts Protein Ubiquitylation and Accumulation at Sites of DNA Damage, Facilitating Double-Strand Break Repair." in: Molecular cell, Vol. 69, Issue 5, pp. 866-878.e7, (2019) (PubMed).: "Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury. ..." in: The Journal of clinical investigation, Vol. 129, Issue 2, pp. 786-801, (2019) (PubMed).
: "MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites." in: Scientific reports, Vol. 8, Issue 1, pp. 10888, (2018) (PubMed).
: "Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair." in: Cell, Vol. 175, Issue 2, pp. 558-570.e11, (2018) (PubMed).
: "The anaphase promoting complex impacts repair choice by protecting ubiquitin signalling at DNA damage sites." in: Nature communications, Vol. 8, pp. 15751, (2017) (PubMed).
: "Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 and RAP80 in Fanconi anemia pathway-deficient cells." in: Nucleic acids research, Vol. 44, Issue 2, pp. 648-56, (2016) (PubMed).
: "Triapine disrupts CtIP-mediated homologous recombination repair and sensitizes ovarian cancer cells to PARP and topoisomerase inhibitors." in: Molecular cancer research : MCR, Vol. 12, Issue 3, pp. 381-93, (2014) (PubMed).
: "Fine-tuning of DNA damage-dependent ubiquitination by OTUB2 supports the DNA repair pathway choice." in: Molecular cell, Vol. 53, Issue 4, pp. 617-30, (2014) (PubMed).
: "Rap80 protein recruitment to DNA double-strand breaks requires binding to both small ubiquitin-like modifier (SUMO) and ubiquitin conjugates." in: The Journal of biological chemistry, Vol. 287, Issue 30, pp. 25510-9, (2012) (PubMed).
: "NBA1/MERIT40 and BRE interaction is required for the integrity of two distinct deubiquitinating enzyme BRCC36-containing complexes." in: The Journal of biological chemistry, Vol. 286, Issue 13, pp. 11734-45, (2011) (PubMed).
Synonyms and alternative names related to UIMC1
ubiquitin interaction motif containing 1 (UIMC1), ubiquitin interaction motif containing 1 (Uimc1), 9430016E08Rik, D330018D10Rik, D630032M02Rik, RAP80, RGD1307009, RIP110, Rxrip110, UIMC1, X2HRIP110Protein level used designations for UIMC1
- ubiquitin interaction motif containing 1
- BRCA1-A complex subunit RAP80-like
- BRCA1-A complex subunit RAP80
- receptor-associated protein 80
- ubiquitin interaction motif-containing protein 1
- receptor associated protein 80
- retinoid X receptor-interacting protein 110
- retinoid x receptor interacting protein
- retinoid X receptor interacting protein 110
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