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UIMC1 抗体 (C-Term)

UIMC1 适用: 人 WB, FACS 宿主: 兔 Polyclonal RB48354 unconjugated
产品编号 ABIN1944736
发货至: 中国
  • 抗原 See all UIMC1 抗体
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    抗原表位
    • 6
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 567-601, C-Term
    适用
    • 31
    • 8
    • 5
    宿主
    • 28
    • 2
    • 1
    克隆类型
    • 31
    多克隆
    标记
    • 21
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This UIMC1 antibody is un-conjugated
    应用范围
    • 18
    • 9
    • 6
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS)
    纯化方法
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    免疫原
    This UIMC1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 567-601 amino acids from the C-terminal region of human UIMC1.
    克隆位点
    RB48354
    亚型
    Ig Fraction
    Top Product
    Discover our top product UIMC1 Primary Antibody
  • 应用备注
    WB: 1:1000. FC: 1:25
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    有效期
    6 months
  • Yan, Kim, Jetten: "RAP80, a novel nuclear protein that interacts with the retinoid-related testis-associated receptor." in: The Journal of biological chemistry, Vol. 277, Issue 35, pp. 32379-88, (2002) (PubMed).

  • 抗原
    UIMC1 (Ubiquitin Interaction Motif Containing 1 (UIMC1))
    别名
    UIMC1 (UIMC1 产品)
    别名
    UIMC1 antibody, RAP80 antibody, X2HRIP110 antibody, 9430016E08Rik antibody, D330018D10Rik antibody, D630032M02Rik antibody, RIP110 antibody, Rxrip110 antibody, RGD1307009 antibody, ubiquitin interaction motif containing 1 antibody, UIMC1 antibody, Uimc1 antibody
    背景
    Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Plays a central role in the BRCA1-A complex by specifically binding 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. Also weakly binds monoubiquitin but with much less affinity than 'Lys-63'-linked ubiquitin. May interact with monoubiquitinated histones H2A and H2B, the relevance of such results is however unclear in vivo. Does not bind Lys-48'-linked ubiquitin. May indirectly act as a transcriptional repressor by inhibiting the interaction of NR6A1 with the corepressor NCOR1.
    分子量
    79727
    基因ID
    51720
    UniProt
    Q96RL1
    途径
    DNA Damage Repair, Nuclear Hormone Receptor Binding, Positive Regulation of Response to DNA Damage Stimulus
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