UHRF1 产品
(Ubiquitin-Like, Containing PHD and RING Finger Domains, 1 (UHRF1))
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This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Featured UHRF1 Categories
Recommended UHRF1 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, IF, IHC
Validations
- (7)
Cat. No.
ABIN3023232
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (9)
Cat. No.
ABIN5542545
Quantity
0.1 mg
Datasheet
Datasheet
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (2)
- (4)
Cat. No.
ABIN565416
Quantity
100 μg
Datasheet
Datasheet
Recommended UHRF1 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6971052
Quantity
96 tests
Datasheet
Datasheet
Recommended UHRF1 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7125644
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1324607
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3096266
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our UHRF1 Products
: "Transcription factor ICBP90 regulates the MIF promoter and immune susceptibility locus." in: The Journal of clinical investigation, Vol. 126, Issue 2, pp. 732-44, (2016) (PubMed).: "Inhibiting UHRF1 expression enhances radiosensitivity in human esophageal squamous cell carcinoma." in: Molecular biology reports, Vol. 40, Issue 9, pp. 5225-35, (2013) (PubMed).
: "M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, Issue 13, pp. 4828-33, (2012) (PubMed).
: "The USP7/Dnmt1 complex stimulates the DNA methylation activity of Dnmt1 and regulates the stability of UHRF1." in: Nucleic acids research, Vol. 39, Issue 19, pp. 8355-65, (2011) (PubMed).
: "DNMT1 stability is regulated by proteins coordinating deubiquitination and acetylation-driven ubiquitination." in: Science signaling, Vol. 3, Issue 146, pp. ra80, (2010) (PubMed).
: "Interplay between Np95 and Eme1 in the DNA damage response." in: Biochemical and biophysical research communications, Vol. 375, Issue 3, pp. 321-5, (2008) (PubMed).
: "Genomic structure and chromosomal mapping of the gene coding for ICBP90, a protein involved in the regulation of the topoisomerase IIalpha gene expression." in: Gene, Vol. 266, Issue 1-2, pp. 15-23, (2001) (PubMed).
: "ICBP90, a novel human CCAAT binding protein, involved in the regulation of topoisomerase IIalpha expression." in: Cancer research, Vol. 60, Issue 1, pp. 121-8, (2000) (PubMed).
Synonyms and alternative names related to UHRF1
ubiquitin like with PHD and ring finger domains 1 (UHRF1), ubiquitin-like, containing PHD and RING finger domains, 1 (Uhrf1), ubiquitin-like with PHD and ring finger domains 1 (Uhrf1), ubiquitin-like with PHD and ring finger domains 1 (uhrf1), ubiquitin like with PHD and ring finger domains 1 (Uhrf1), AL022808, fb97f09, hNP95, hUHRF1, ICBP90, Np95, NP95, RNF106, UHRF1, wu:fb97f09, zgc:63539Protein level used designations for UHRF1
- E3 ubiquitin-protein ligase UHRF1
- RING finger protein 106
- huNp95
- inverted CCAAT box-binding protein of 90 kDa
- nuclear protein 95
- nuclear zinc finger protein Np95
- transcription factor ICBP90
- ubiquitin-like PHD and RING finger domain-containing protein 1
- ubiquitin-like, containing PHD and RING finger domains, 1
- ubiquitin-like-containing PHD and RING finger domains protein 1
- mUhrf1
- liver regeneration-related protein LRRG126
- ubiquitin-like with PHD and ring finger domains 1
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