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抗Human Superoxide dismutase copper chaperone 抗体:
抗Mouse (Murine) Superoxide dismutase copper chaperone 抗体:
抗Rat (Rattus) Superoxide dismutase copper chaperone 抗体:
Human Monoclonal Superoxide dismutase copper chaperone Primary Antibody for IF, IHC (p) - ABIN523352
Spinazzi, Sghirlanzoni, Salviati, Angelini: Impaired copper and iron metabolism in blood cells and muscles of patients affected by copper deficiency myeloneuropathy. in Neuropathology and applied neurobiology 2014
Data indicate that transgenic plants expressing miR398-resistant forms of CSD1, CSD2 (显示 TGFB1 抗体) and CCS under the control of their native promoters are more sensitive to heat stress.
miR398 links expression of the three major chloroplast copper proteins, plastocyanin, CCS1 and Csd2 (显示 TGFB1 抗体), to copper availability.
CCS1 gene encodes both a cytosolic and a chloroplastic form of CCS1. miR398 directs the post-transcriptional regulation of CCS1 mRNAs by cleavage and AGO10-mediated translational repression. [CCS1]
Arabidopsis thaliana gene AtCCS encodes a functional homolog to yeast Ccs1p/Lys7p, a copper chaperone for SOD [AtCCS]
The structure and function of the CCS gene of A. thaliana, including its copper and protein binding domains, are reported.
In addition to Atox1 (显示 ATOX1 抗体), the human cytoplasm also contains Cu chaperones for loading of superoxide dismutase 1 (显示 SOD1 抗体) (i.e. CCS) and cytochrome c (显示 CYCS 抗体) oxidase in mitochondria (i.e. Cox17 (显示 COX17 抗体)). [review]
Human cytoplasmic copper chaperones Atox1 (显示 ATOX1 抗体) and CCS exchange copper ions in vitro
Coexpression of hCCS (显示 HCCS 抗体) in the presence of copper restores the correct maturation of the SOD1 (显示 SOD1 抗体) mutants and prevents the formation of the unstructured species, confirming that hCCS (显示 HCCS 抗体) also acts as a molecular chaperone (显示 HSP90AA1 抗体).
CCS mRNA and protein levels in the serum are not correlated with inflammatory processes.
CTR1 (显示 SLC31A1 抗体) silencing increased the protein levels of copper chaperone ATOX1 (显示 ATOX1 抗体) and copper chaperone for superoxide dismutase 1 (显示 SOD1 抗体) (CCS-1), but decreased copper chaperone for cytochrome c (显示 CYCS 抗体) oxidase (COX17 (显示 COX17 抗体)).
CCS1 serves as a specialized import receptor in mitochondria that facilitates the import and folding of SOD1 (显示 SOD1 抗体) and CCS1.
CCS-dependent copper acquisition and distribution largely occur at membrane interfaces and that this emerging role of the bilayer may reflect a general mechanistic aspect of cellular transition metal ion acquisition.
CCS-1 facilitates copper trafficking to the mitochondria, but does not affect the transfer of copper to the cytochrome c (显示 CYCS 抗体) oxidase.
The CCS mutation, p.Arg163Trp, causes reduced SOD1 (显示 SOD1 抗体) activity and may impair other mechanisms important for normal Cu homeostasis.
analysis of human superoxide dismutase 1 (hSOD1 (显示 SOD1 抗体)) maturation through interaction with human copper chaperone for SOD1 (hCCS (显示 HCCS 抗体))
results suggest that a SOD1 (显示 SOD1 抗体) supplement to healthy mice may not be necessary to modulate cell proliferation and neuroblast differentiation in the dentate gyrus
Small interfering RNA (siRNA) targeting CCS was introduced into metallothionein (显示 MT 抗体)-knockout mouse fibroblasts (MT-KO cells) and their wild type cells (MT-WT cells) to reveal the interactive role of CCS with other Cu-regulating proteins.
CCS is necessary for the efficient incorporation of copper into SOD1 (显示 SOD1 抗体) in motor neurons, but it does not modify the onset and progression of motor neuron disease in SOD1 (显示 SOD1 抗体)-mutant mice.
CCS-independent activation of mammalian SOD1 (显示 SOD1 抗体) involves glutathione
Associated with copper deficiency were higher levels of Ccs in erythrocytes.
A mechanism determining the abundance of CCS that is competitive with the process of copper delivery to SOD1 (显示 SOD1 抗体) is described, revealing a unique post-translational component of intracellular copper homeostasis.
These results establish that CCS/G93A SOD1 (显示 SOD1 抗体) mice manifest an isolated complex IV deficiency which may underlie a substantial part of mutant SOD1 (显示 SOD1 抗体)-induced mitochondrial cytopathy.
Study finds that as expected, CCS over-expression promotes oxidation of a wild-type SOD1 (显示 SOD1 抗体) disulfide; however, in the diseased G93A/CCS mouse, there was no increased oxidation of the mutant SOD1 (显示 SOD1 抗体) disulfide.
effects of copper chaperone for SOD1 on mitochondrial dysfunction are SOD1 (显示 SOD1 抗体) mutation dependent and correlate with SOD1 (显示 SOD1 抗体) redox susceptibility
Copper chaperone for superoxide dismutase specifically delivers Cu to copper/zinc superoxide dismutase and may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor.
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