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TRPM2 产品

(Transient Receptor Potential Cation Channel, Subfamily M, Member 2 (TRPM2))

Categories

The protein encoded by this gene is a calcium-permeable cation channel that is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008].

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Featured TRPM2 Categories

TRPM2 抗体

High quality antibodies with extensive validation data.

TRPM2 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TRPM2 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ELISA, IF
Validations
  • (6)
Cat. No. ABIN7172859
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB, IHC, ELISA
Validations
  • (3)
Cat. No. ABIN7172857
Quantity 100 μL
Datasheet Datasheet
Reactivity Guinea Pig, Human, Mouse, Rat
Application WB, IHC, IHC (p)
Validations
  • (3)
Cat. No. ABIN490062
Quantity 50 μg
Datasheet Datasheet

Recommended TRPM2 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3074941
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3127490
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3096095
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TRPM2 Products

Gattkowski, Johnsen, Bauche, Möckl, Kulow, Garcia Alai, Rutherford, Fliegert, Tidow: "Novel CaM-binding motif in its NudT9H domain contributes to temperature sensitivity of TRPM2." in: Biochimica et biophysica acta. Molecular cell research, (2018) (PubMed).

Yee, Freestone, Bai, Lipski: "Paradoxical lower sensitivity of Locus Coeruleus than Substantia Nigra pars compacta neurons to acute actions of rotenone." in: Experimental neurology, Vol. 287, Issue Pt 1, pp. 34-43, (2016) (PubMed).

Chung, Asgar, Lee, Shim, Dumler, Ro: "The role of TRPM2 in hydrogen peroxide-induced expression of inflammatory cytokine and chemokine in rat trigeminal ganglia." in: Neuroscience, Vol. 297, pp. 160-9, (2015) (PubMed).

Rah, Kwak, Chung, Kim: "ADP-ribose/TRPM2-mediated Ca2+ signaling is essential for cytolytic degranulation and antitumor activity of natural killer cells." in: Scientific reports, Vol. 5, pp. 9482, (2015) (PubMed).

Vaisitti, Audrito, Serra, Buonincontri, Sociali, Mannino, Pagnani, Zucchetto, Tissino, Vitale, Coscia, Usai, Pepper, Gattei, Bruzzone, Deaglio: "The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting." in: Leukemia, Vol. 29, Issue 2, pp. 356-68, (2015) (PubMed).

Roberge, Roussel, Andersson, Meli, Vidal, Blandel, Lanner, Le Guennec, Katz, Westerblad, Lacampagne, Fauconnier: "TNF-α-mediated caspase-8 activation induces ROS production and TRPM2 activation in adult ventricular myocytes." in: Cardiovascular research, Vol. 103, Issue 1, pp. 90-9, (2014) (PubMed).

Lu, Xiang, Clemmer, Mittwede, Hester: "Oxidative stress increases pulmonary vascular permeability in diabetic rats through activation of transient receptor potential melastatin 2 channels." in: Microcirculation (New York, N.Y. : 1994), Vol. 21, Issue 8, pp. 754-60, (2014) (PubMed).

Moreau, Kirchberger, Swarbrick, Bartlett, Fliegert, Yorgan, Bauche, Harneit, Guse, Potter: "Structure-activity relationship of adenosine 5'-diphosphoribose at the transient receptor potential melastatin 2 (TRPM2) channel: rational design of antagonists." in: Journal of medicinal chemistry, Vol. 56, Issue 24, pp. 10079-102, (2013) (PubMed).

Melzer, Hicking, Göbel, Wiendl: "TRPM2 cation channels modulate T cell effector functions and contribute to autoimmune CNS inflammation." in: PLoS ONE, Vol. 7, Issue 10, pp. e47617, (2012) (PubMed).

Chung, Freestone, Lipski: "Expression and functional properties of TRPM2 channels in dopaminergic neurons of the substantia nigra of the rat." in: Journal of neurophysiology, Vol. 106, Issue 6, pp. 2865-75, (2011) (PubMed).

Synonyms and alternative names related to TRPM2

transient receptor potential cation channel subfamily M member 2 (TRPM2), transient receptor potential cation channel, subfamily M, member 2 (Trpm2), transient receptor potential cation channel, subfamily M, member 2 (trpm2), transient receptor potential cation channel subfamily C member 7 (TRPC7), transient receptor potential cation channel subfamily M member 2 (trpm2), transient receptor potential cation channel subfamily M member 2 (Trpm2), 9830168K16Rik, C79133, EREG1, KNP3, LTRPC2, NUDT9H, NUDT9L1, si:ch73-263b18.1, Trp7, TRPC7, TRPM2, Trpm2-predicted, Trrp7

Protein level used designations for TRPM2

  • LTrpC-2
  • estrogen-responsive element-associated gene 1 protein
  • long transient receptor potential channel 2
  • transient receptor potential cation channel subfamily M member 2
  • transient receptor potential channel 7
  • transient receptor potential melastatin family 2
  • transient receptor potential cation channel, subfamily M, member 2
  • transient receptor potential cation channel, subfamily C, member 7
  • transient receptor potential cation channel, subfamily C, member 7-like
  • transient receptor potential cation channel subfamily M member 2-like
  • transient receptor protein 7
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