TRPC4 产品
(Transient Receptor Potential Cation Channel, Subfamily C, Member 4 (TRPC4))
Categories
This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].
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Featured TRPC4 Categories
Recommended TRPC4 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human, Mouse, Rat
Application
IHC
Validations
- (17)
Cat. No.
ABIN571659
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat
Application
WB, IHC
Validations
- (5)
Cat. No.
ABIN2776213
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (3)
Cat. No.
ABIN570934
Quantity
100 μg
Datasheet
Datasheet
Recommended TRPC4 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6208207
Quantity
96 tests
Datasheet
Datasheet
Recommended TRPC4 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3118839
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
- (1)
Cat. No.
ABIN3137354
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3130418
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TRPC4 Products
: "Intestinal myofibroblast TRPC6 channel may contribute to stenotic fibrosis in Crohn's disease." in: Inflammatory bowel diseases, Vol. 21, Issue 3, pp. 496-506, (2015) (PubMed).: "Novel role for TRPC4 in regulation of macroautophagy by a small molecule in vascular endothelial cells." in: Biochimica et biophysica acta, Vol. 1853, Issue 2, pp. 377-87, (2015) (PubMed).
: "Decreased anxiety-like behavior and Gαq/11-dependent responses in the amygdala of mice lacking TRPC4 channels." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 34, Issue 10, pp. 3653-67, (2014) (PubMed).
: "Increased expression of TRPC4 channels associated with erectile dysfunction in diabetes." in: Andrology, Vol. 2, Issue 4, pp. 550-8, (2014) (PubMed).
: "Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility." in: The Journal of biological chemistry, Vol. 288, Issue 46, pp. 32941-51, (2013) (PubMed).
: "Selective G?i subunits as novel direct activators of transient receptor potential canonical (TRPC)4 and TRPC5 channels." in: The Journal of biological chemistry, Vol. 287, Issue 21, pp. 17029-39, (2012) (PubMed).
: "Mechanisms and roles of muscarinic activation in guinea-pig adrenal medullary cells." in: American journal of physiology. Cell physiology, Vol. 303, Issue 6, pp. C635-44, (2012) (PubMed).
: "Mass spectrometric analysis of novel phosphorylation sites in the TRPC4? channel." in: Rapid communications in mass spectrometry : RCM, Vol. 26, Issue 17, pp. 1965-70, (2012) (PubMed).
: "Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes." in: The Journal of biological chemistry, Vol. 285, Issue 50, pp. 39171-9, (2010) (PubMed).
: "Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 8, pp. 2425-37, (2009) (PubMed).
Synonyms and alternative names related to TRPC4
transient receptor potential cation channel subfamily C member 4 (TRPC4), short transient receptor potential channel 4 (LOC100538928), transient receptor potential cation channel subfamily C member 4 (trpc4), transient receptor potential cation channel, subfamily C, member 4 (Trpc4), transient receptor potential cation channel subfamily C member 4 (Trpc4), CCE1, HTRP-4, HTRP4, STRPC4, TRP4, Trp4, TRPC4, TRPC5, Trrp4Protein level used designations for TRPC4
- transient receptor potential 4
- transient receptor potential cation channel, subfamily C, member 5
- transient receptor potential cation channel, subfamily C, member 4
- short transient receptor potential channel 4-like
- short transient receptor potential channel 4
- trp-related protein 4
- capacitative calcium entry channel Trp4
- putative capacitative calcium entry channel
- receptor-activated cation channel TRP4
- transient receptor protein 4
- CCE1
- capacitative calcium entry channel 1
- transient receptor potential channel 4
- transient receptor potential protein 4
- transient receptor potential cation channel TRPC4 middle region 2
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