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TRPC6 产品

(Transient Receptor Potential Cation Channel, Subfamily C, Member 6 (TRPC6))
The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009].

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Featured TRPC6 Categories

TRPC6 抗体

High quality antibodies with extensive validation data.

TRPC6 ELISA试剂盒

Reliable ELISA kits for a wide range of species.

TRPC6 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended TRPC6 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (7)
Cat. No. ABIN7441304
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, IHC
Validations
  • (4)
Cat. No. ABIN6149580
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Rat
Application WB, IHC (p)
Validations
  • (1)
  • (4)
Cat. No. ABIN3044146
Quantity 100 μg
Datasheet Datasheet

Recommended TRPC6 ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6960122
Quantity 96 tests
Datasheet Datasheet

Recommended TRPC6 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1323826
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3074745
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3122878
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our TRPC6 Products

Wang, Wang, Li: "TRPC1/TRPC3 channels mediate lysophosphatidylcholine-induced apoptosis in cultured human coronary artery smooth muscles cells." in: Oncotarget, Vol. 7, Issue 32, pp. 50937-50951, (2018) (PubMed).

Alonso-González, Cabo, San José, Gago, Suazo, García-Suárez, Cobo, Vega: "Human Digital Meissner Corpuscles Display Immunoreactivity for the Multifunctional Ion Channels Trpc6 and Trpv4." in: Anatomical record (Hoboken, N.J. : 2007), Vol. 300, Issue 6, pp. 1022-1031, (2018) (PubMed).

Wajdner, Farrington, Barnard, Peachell, Schnackenberg, Marino, Xu, Affleck, Begg, Seward: "Orai and TRPC channel characterization in FcεRI-mediated calcium signaling and mediator secretion in human mast cells." in: Physiological reports, Vol. 5, Issue 5, (2017) (PubMed).

Álvarez-Miguel, Cidad, Pérez-García, López-López: "Differences in TRPC3 and TRPC6 channels assembly in mesenteric vascular smooth muscle cells in essential hypertension." in: The Journal of physiology, (2016) (PubMed).

Takada, Furuya, Sokabe: "Mechanosensitive ATP release from hemichannels and Ca²⁺ influx through TRPC6 accelerate wound closure in keratinocytes." in: Journal of cell science, Vol. 127, Issue Pt 19, pp. 4159-71, (2014) (PubMed).

Anderson, Kim, Hagmann, Benzing, Dryer: "Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol." in: American journal of physiology. Cell physiology, Vol. 305, Issue 3, pp. C276-89, (2013) (PubMed).

Kim, Anderson, Wilson, Hagmann, Benzing, Dryer: "NOX2 interacts with podocyte TRPC6 channels and contributes to their activation by diacylglycerol: essential role of podocin in formation of this complex." in: American journal of physiology. Cell physiology, Vol. 305, Issue 9, pp. C960-71, (2013) (PubMed).

Li, Ding, Lopez, Takeshima, Ma, Allen, Eltit: "Impaired Orai1-mediated resting Ca2+ entry reduces the cytosolic [Ca2+] and sarcoplasmic reticulum Ca2+ loading in quiescent junctophilin 1 knock-out myotubes." in: The Journal of biological chemistry, Vol. 285, Issue 50, pp. 39171-9, (2010) (PubMed).

Ding, He, Zhou, Cheng, Yao, Lu, Cai, Jin, Dong, Xu, Wang: "Essential role of TRPC6 channels in G2/M phase transition and development of human glioma." in: Journal of the National Cancer Institute, Vol. 102, Issue 14, pp. 1052-68, (2010) (PubMed).

Potier, Gonzalez, Motiani, Abdullaev, Bisaillon, Singer, Trebak: "Evidence for STIM1- and Orai1-dependent store-operated calcium influx through ICRAC in vascular smooth muscle cells: role in proliferation and migration." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 8, pp. 2425-37, (2009) (PubMed).

Synonyms and alternative names related to TRPC6

transient receptor potential cation channel subfamily C member 6 (TRPC6), transient receptor potential cation channel, subfamily C, member 6 (Trpc6), transient receptor potential cation channel, subfamily C, member 6a (trpc6a), transient receptor potential cation channel subfamily C member 6 (Trpc6), transient receptor potential cation channel subfamily C member 6 (trpc6), AV025995, bZ1P14.9, FSGS2, LLHWJM002, LLHWJM003, LLHWJM004, mtrp6, si:rp71-1p14.9, TRP-6, TRP6, trp6, trpc6, Trrp6

Protein level used designations for TRPC6

  • TRP-6
  • short transient receptor potential channel 6
  • transient receptor protein 6
  • calcium entry channel
  • transient receptor potential cation channel, subfamily C, member 6
  • transient receptor potential channel subfamily C member 6
  • short transient receptor potential channel 6-like
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