TNNT3 产品
(Fast Skeletal Troponin T (TNNT3))
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The binding of Ca(2+) to the trimeric troponin complex initiates the process of muscle contraction. Increased Ca(2+) concentrations produce a conformational change in the troponin complex that is transmitted to tropomyosin dimers situated along actin filaments. The altered conformation permits increased interaction between a myosin head and an actin filament which, ultimately, produces a muscle contraction. The troponin complex has protein subunits C, I, and T. Subunit C binds Ca(2+) and subunit I binds to actin and inhibits actin-myosin interaction. Subunit T binds the troponin complex to the tropomyosin complex and is also required for Ca(2+)-mediated activation of actomyosin ATPase activity. There are 3 different troponin T genes that encode tissue-specific isoforms of subunit T for fast skeletal-, slow skeletal-, and cardiac-muscle. This gene encodes fast skeletal troponin T protein\; also known as troponin T type 3. Alternative splicing results in multiple transcript variants encoding additional distinct troponin T type 3 isoforms. A developmentally regulated switch between fetal/neonatal and adult troponin T type 3 isoforms occurs. Additional splice variants have been described but their biological validity has not been established. Mutations in this gene may cause distal arthrogryposis multiplex congenita type 2B (DA2B). [provided by RefSeq, Oct 2009].
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Featured TNNT3 Categories
TNNT3 抗体
High quality antibodies with extensive validation data.
TNNT3 ELISA试剂盒
Reliable ELISA kits for a wide range of species.
TNNT3 蛋白
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended TNNT3 抗体
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
- (2)
Cat. No.
ABIN563217
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human, Mouse
Application
WB, ELISA, IHC, ICC, IF
Validations
- (2)
Cat. No.
ABIN6257189
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Chicken, Human, Quail
Application
WB, ELISA, IHC, IHC (p), IHC (fro)
Validations
- (2)
Cat. No.
ABIN462336
Quantity
50 μg
Datasheet
Datasheet
Recommended TNNT3 ELISA试剂盒
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6963595
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970896
Quantity
96 tests
Datasheet
Datasheet
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
Cat. No.
ABIN6970897
Quantity
96 tests
Datasheet
Datasheet
Recommended TNNT3 蛋白
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1323292
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3074520
Quantity
1 mg
Datasheet
Datasheet
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN3130583
Quantity
1 mg
Datasheet
Datasheet
Latest Publications for our TNNT3 Products
: "Calpain inhibition rescues troponin T3 fragmentation, increases Cav1.1, and enhances skeletal muscle force in aging sedentary mice." in: Aging cell, Vol. 15, Issue 3, pp. 488-98, (2016) (PubMed).: "Hypothyroidism and its rapid correction alter cardiac remodeling." in: PLoS ONE, Vol. 9, Issue 10, pp. e109753, (2014) (PubMed).
: "Troponin T nuclear localization and its role in aging skeletal muscle." in: Age (Dordrecht, Netherlands), Vol. 35, Issue 2, pp. 353-70, (2013) (PubMed).
: "Nonmyofilament-associated troponin T3 nuclear and nucleolar localization sequence and leucine zipper domain mediate muscle cell apoptosis." in: Cytoskeleton (Hoboken, N.J.), Vol. 70, Issue 3, pp. 134-47, (2013) (PubMed).
: "Proteome dynamics during contractile and metabolic differentiation of bovine foetal muscle." in: Animal : an international journal of animal bioscience, Vol. 3, Issue 7, pp. 980-1000, (2012) (PubMed).
: "A novel mutation in TNNT3 associated with Sheldon-Hall syndrome in a Chinese family with vertical talus." in: European journal of medical genetics, Vol. 54, Issue 3, pp. 351-3, (2011) (PubMed).
Synonyms and alternative names related to TNNT3
troponin T3, fast skeletal type (TNNT3), troponin T3, skeletal, fast (Tnnt3), troponin T3, fast skeletal type S homeolog (tnnt3.S), troponin T3, fast skeletal type (Tnnt3), troponin T type 3 (skeletal, fast) (TNNT3), troponin T1, slow skeletal type (TNNT1), fTnT, Tnnt3, tnnt3a, Tnt, TNTF, TnTfProtein level used designations for TNNT3
- troponin T variant TnTx7-e16
- troponin T, fast skeletal muscle isoforms
- troponin T3, skeletal, fast
- fast skeletal muscle troponin T
- fast skeletal muscle troponin T3
- skeletal muscle fast-twitch TnT
- tnTf
- troponin T, fast skeletal muscle
- beta TnTF
- beta-TnTF
- fTnT
- troponin-T3, skeletal, fast
- troponin T fast skeletal muscle type
- fast skeletal troponin T beta-1 isoform
- skeletal troponin T alpha-1 isoform
- Fast skeletal muscle troponin T
- Troponin T, fast skeletal muscle
- fetal troponin T 1
- fetal troponin T 2
- troponin T 2f
- troponin T 2fa
- troponin T 4f
- troponin T1f
- troponin T type 1 (skeletal, slow)
- troponin T, slow skeletal muscle
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