anti-人 Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon 抗体 for Immunofluorescence (Paraffin-embedded Sections)

Recommended Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Antibody (supplied by: Log in to see )

抗原
Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) 抗体
  • zgc:100844
  • IKBKE
  • MGC130907
  • IKK-E
  • IKK-i
  • IKKE
  • IKKI
  • AW558201
  • IKKepsilon
  • Ikki
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
  • inhibitor of nuclear factor kappa B kinase subunit epsilon
  • inhibitor of nuclear factor kappa B kinase subunit epsilon L homeolog
  • inhibitor of kappaB kinase epsilon
  • IKBKE
  • ikbke
  • ikbke.L
  • Ikbke
抗原表位
pSer172
17
15
12
10
10
9
8
7
7
6
6
6
4
3
3
2
1
1
1
1
1
适用
人, 小鼠, 大鼠
117
54
28
2
2
2
2
1
1
1
1
1
宿主

108
29
克隆类型
多克隆
标记
非结合性
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
1
1
应用范围
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
116
64
49
20
14
4
4
2
2
1
选项
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产品编号 ABIN1387735
$ 328.90
加上运输费 $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
4 ABIN754033 IF (p) IHC (p) WB Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN902020 IF (p) Alexa Fluor 488 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN902019 IF (p) Alexa Fluor 350 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN902022 IF (p) Alexa Fluor 647 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN754037 IF (p) Cy5 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN754036 IF (p) Cy3 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN754039 IF (p) Cy7 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN754038 IF (p) Cy5.5 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN754040 IF (p) FITC Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN902021 IF (p) Alexa Fluor 555 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN2814703 IF (p) Alexa Fluor 594 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN5005220 IF (p) Alexa Fluor 750 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN5005219 IF (p) Alexa Fluor 680 Rabbit IgG AA 530-580 Log in to see Polyclonal 0
1 ABIN872297 IF (p) IHC (p) WB Rabbit IgG pThr501 Log in to see Polyclonal 0

General

抗原 Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) 抗体
抗原表位 pSer172
(17), (15), (12), (10), (10), (9), (8), (7), (7), (6), (6), (6), (4), (3), (3), (2), (1), (1), (1), (1), (1)
适用 人, 小鼠, 大鼠
(117), (54), (28), (2), (2), (2), (2), (1), (1), (1), (1), (1)
宿主
(108), (29)
克隆类型
多克隆
标记 非结合性
(5), (5), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
应用范围 Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(116), (64), (49), (20), (14), (4), (4), (2), (2), (1)
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产品细节

目标详细情况 使用细节 贮存及处理 图像
纯化方法 Purified by Protein A.
免疫原 KLH conjugated synstic phosphopeptide derived from human IKKi/IKKE around the phosphorylation site of Ser172 [FV(p-S)VY]
亚型 IgG

目标详细情况

产品细节 使用细节 贮存及处理 图像 回页首
抗原
别名 IKKi (IKBKE Antibody 摘要)
背景

Serine/threonine kinase that plays an essential role in regulating inflammatory responses to viral infection, through the activation of the type I IFN, NF-kappa-B and STAT signaling. Also involved in TNFA and inflammatory cytokines, like Interleukin-1, signaling. Following activation of viral RNA sensors, such as RIG-I-like receptors, associates with DDX3X and phosphorylates interferon regulatory factors (IRFs), IRF3 and IRF7, as well as DDX3X. This activity allows subsequent homodimerization and nuclear translocation of the IRF3 leading to transcriptional activation of pro-inflammatory and antiviral genes including IFNB. In order to establish such an antiviral state, IKBKE forms several different complexes whose composition depends on the type of cell and cellular stimuli. Thus, several scaffolding molecules including IPS1/MAVS, TANK, AZI2/NAP1 or TBKBP1/SINTBAD can be recruited to the IKBKE-containing-complexes. Activated by polyubiquitination in response to TNFA and interleukin-1, regulates the NF-kappa-B signaling pathway through, at least, the phosphorylation of CYLD. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. In addition, is also required for the induction of a subset of ISGs which displays antiviral activity, may be through the phosphorylation of STAT1 at 'Ser-708'. Phosphorylation of STAT1 at 'Ser-708' seems also to promote the assembly and DNA binding of ISGF3 (STAT1:STAT2:IRF9) complexes compared to GAF (STAT1:STAT1) complexes, in this way regulating the balance between type I and type II IFN responses. Protects cells against DNA damage-induced cell death. Also plays an important role in energy balance regulation by sustaining a state of chronic, low-grade inflammation in obesity, wich leads to a negative impact on insulin sensitivity. Phosphorylates AKT1.

Synonyms: IKKE, IKKI, IKK-E, IKK-i, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, I-kappa-B kinase epsilon, IKK-epsilon, IkBKE, Inducible I kappa-B kinase, KIAA0151

基因ID 9641
UniProt Q14164
途径 TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

使用细节

产品细节 目标详细情况 贮存及处理 图像 回页首
应用备注 WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
限制 仅限研究用

贮存及处理

产品细节 目标详细情况 使用细节 图像 回页首
状态 Liquid
浓度 1 μg/μL
缓冲液 Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
储存液 Sodium azide
注意事项 This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
储存条件 -20 °C
储存方法 Store at -20°C
有效期 12 months

图像

产品细节 目标详细情况 使用细节 贮存及处理 回页首
厂商提供的图像
Flow Cytometry (FACS) image for anti-Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) (pSer172) antibody (ABIN1387735) Mouse spleen cells probed with Rabbit Anti-IKKi(Ser172) Polyclonal Antibody at 1:100...