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Phosphatidylinositol Binding clathrin Assembly Protein 蛋白

(Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10\;11)(p13\;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011].
PICALM Protein (AA 1-610) (GST tag) PICALM Protein (AA 1-610) (GST tag) PICALM Protein (AA 1-610) (GST tag) (ABIN1315001)

PICALM 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA

PICALM Protein (AA 2-652) (His tag) PICALM Protein (AA 2-652) (His tag) PICALM Protein (AA 2-652) (His tag) (ABIN3086159)

Crystallography grade PICALM 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

PICALM Protein (AA 2-660) (His tag) PICALM Protein (AA 2-660) (His tag) PICALM Protein (AA 2-660) (His tag) (ABIN3135908)

Crystallography grade PICALM 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys

Phosphatidylinositol Binding clathrin Assembly Protein 蛋白 by Grade

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Phosphatidylinositol Binding clathrin Assembly Protein 蛋白 by Origin

Find Phosphatidylinositol Binding clathrin Assembly Protein 蛋白 for a variety of species such as anti-Human Phosphatidylinositol Binding clathrin Assembly Protein, anti-Mouse Phosphatidylinositol Binding clathrin Assembly Protein, anti-Rat Phosphatidylinositol Binding clathrin Assembly Protein. The species listed below are among those available. Click on a link to go to the corresponding products.

Phosphatidylinositol Binding clathrin Assembly Protein 蛋白 by Source

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Phosphatidylinositol Binding clathrin Assembly Protein 蛋白 by 蛋白类型

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Phosphatidylinositol Binding clathrin Assembly Protein 蛋白 by 应用范围

Find Phosphatidylinositol Binding clathrin Assembly Protein 蛋白 validated for a specific application such as ELISA, WB, SDS, Crys. Some of the available applications are listed below. Click on a link to go to the corresponding products.

Popular Phosphatidylinositol Binding clathrin Assembly Protein 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
Cat. No. ABIN1315001
Quantity 10 μg
Datasheet Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3086159
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3135908
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (1)
Cat. No. ABIN2728884
Quantity 20 μg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
Cat. No. ABIN7408408
Quantity 100 μg
Datasheet Datasheet
Reactivity Rat
Source Yeast
Validations
Cat. No. ABIN1475689
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our Phosphatidylinositol Binding clathrin Assembly Protein 蛋白

Zhao, Sagare, Ma, Halliday, Kong, Kisler, Winkler, Ramanathan, Kanekiyo, Bu, Owens, Rege, Si, Ahuja, Zhu, Miller, Schneider, Maeda, Maeda, Sugawara, Ichida, Zlokovic: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).

Baig, Joseph, Tayler, Abraham, Owen, Williams, Kehoe, Love: "Distribution and expression of picalm in Alzheimer disease." in: Journal of neuropathology and experimental neurology, Vol. 69, Issue 10, pp. 1071-7, (2010) (PubMed).

Aliases for Phosphatidylinositol Binding clathrin Assembly Protein 蛋白

leucine aminopeptidase 3 (LAP3) 蛋白
phosphatidylinositol binding clathrin assembly protein (PICALM) 蛋白
phosphatidylinositol binding clathrin assembly protein (Picalm) 蛋白
si:ch211-200p22.4 (si:ch211-200p22.4) 蛋白
CALM 蛋白
Calm 蛋白
CLTH 蛋白
fit-1 蛋白
fit1 蛋白
LAP 蛋白
LAP-3 蛋白
mKIAA4114 蛋白
PAP180 蛋白
PEPS 蛋白
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