PICALM Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)
(1 reference)-
- 抗原 See all PICALM 蛋白
- PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
- 蛋白类型
- Recombinant
- 产品特性
- Transcript Variant 1
-
宿主
- 人
-
资源
- HEK-293 Cells
- 标记
- This PICALM protein is labelled with Myc-DYKDDDDK Tag.
- 应用范围
- Antibody Production (AbP), Standard (STD)
- 产品特性
-
- Recombinant human PICALM (transcript variant 1) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
- 纯度
- > 80 % as determined by SDS-PAGE and Coomassie blue staining
- Top Product
- Discover our top product PICALM 蛋白
-
Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (AA 1-610) protein (GST tag)
PICALM 宿主: 人 宿主: 小麦胚 Recombinant WB, ELISA, AP, AA
Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (AA 2-652) protein (His tag)Crystallography grade PICALM 宿主: 人 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
Phosphatidylinositol Binding clathrin Assembly Protein (PICALM) (AA 2-660) protein (His tag)Crystallography grade PICALM 宿主: 小鼠 宿主: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. WB, SDS, ELISA, Crys
-
- 应用备注
-
Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays - 说明
-
The tag is located at the C-terminal.
- 限制
- 仅限研究用
-
- 浓度
- 50 μg/mL
- 缓冲液
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
- 储存条件
- -80 °C
- 储存方法
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
-
-
: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).
-
: "Central role for PICALM in amyloid-β blood-brain barrier transcytosis and clearance." in: Nature neuroscience, Vol. 18, Issue 7, pp. 978-87, (2015) (PubMed).
-
- 抗原
- PICALM (Phosphatidylinositol Binding clathrin Assembly Protein (PICALM))
- 别名
- Picalm (PICALM 产品)
- 别名
- LAP-3 Protein, PEPS Protein, CALM Protein, CLTH Protein, LAP Protein, PAP180 Protein, fit-1 Protein, fit1 Protein, mKIAA4114 Protein, Calm Protein, leucine aminopeptidase 3 Protein, phosphatidylinositol binding clathrin assembly protein Protein, si:ch211-200p22.4 Protein, LAP3 Protein, PICALM Protein, Picalm Protein, si:ch211-200p22.4 Protein
- 背景
- This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(1011)(p13q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
- 分子量
- 70.6 kDa
- NCBI登录号
- NP_009097
- 途径
- Synaptic Membrane
-
