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SRF 产品

(Serum Response Factor (SRF))
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways\; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). [provided by RefSeq, Jul 2008].

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Featured SRF Categories

SRF 抗体

High quality antibodies with extensive validation data.

SRF ELISA试剂盒

Reliable ELISA kits for a wide range of species.

SRF 蛋白

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended SRF 抗体

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IF (p), IHC (p), IF (cc), IHC (fro)
Validations
  • (4)
Cat. No. ABIN686017
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (4)
Cat. No. ABIN520472
Quantity 100 μg
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
Cat. No. ABIN6255577
Quantity 100 μL
Datasheet Datasheet

Recommended SRF ELISA试剂盒

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6970415
Quantity 96 tests
Datasheet Datasheet
Reactivity Chicken
Analytical Method
Validations
Cat. No. ABIN1157693
Quantity 96 tests
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
Cat. No. ABIN5691922
Quantity 2 x 96 tests
Datasheet Datasheet

Recommended SRF 蛋白

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1321311
Quantity 10 μg
Datasheet Datasheet
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3130359
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3077546
Quantity 1 mg
Datasheet Datasheet

Latest Publications for our SRF Products

Park, Lee, Yeom, Heo, Lim: "Neuroprotective effect of Ruminococcus albus on oxidatively stressed SH-SY5Y cells and animals." in: Scientific reports, Vol. 7, Issue 1, pp. 14520, (2018) (PubMed).

Haikala, Marques, Turunen, Klefström: "Myc requires RhoA/SRF to reprogram glutamine metabolism." in: Small GTPases, pp. 1-9, (2016) (PubMed).

Werfel, Jungmann, Lehmann, Ksienzyk, Bekeredjian, Kaya, Leuchs, Nordheim, Backs, Engelhardt, Katus, Müller: "Rapid and highly efficient inducible cardiac gene knockout in adult mice using AAV-mediated expression of Cre recombinase." in: Cardiovascular research, Vol. 104, Issue 1, pp. 15-23, (2014) (PubMed).

Stern, Haverkamp, Sinske, Tedeschi, Naumann, Di Giovanni, Kochanek, Nordheim, Knöll: "The transcription factor serum response factor stimulates axon regeneration through cytoplasmic localization and cofilin interaction." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 48, pp. 18836-48, (2013) (PubMed).

Härmä, Knuuttila, Virtanen, Mirtti, Kohonen, Kovanen, Happonen, Kaewphan, Ahonen, Kallioniemi, Grafström, Lötjönen, Nees: "Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models." in: Oncogene, Vol. 31, Issue 16, pp. 2075-89, (2012) (PubMed).

Koegel, von Tobel, Schäfer, Alberti, Kremmer, Mauch, Hohl, Wang, Beer, Bloch, Nordheim, Werner: "Loss of serum response factor in keratinocytes results in hyperproliferative skin disease in mice." in: The Journal of clinical investigation, Vol. 119, Issue 4, pp. 899-910, (2009) (PubMed).

Petit, Lindskog, Larsson, Wasteson, Athley, Breuer, Angstenberger, Hertfelder, Mattsson, Nordheim, Nelander, Lindahl: "Smooth muscle expression of lipoma preferred partner is mediated by an alternative intronic promoter that is regulated by serum response factor/myocardin." in: Circulation research, Vol. 103, Issue 1, pp. 61-9, (2008) (PubMed).

Davis, Gupta, Pogwizd, Bacha, Jeevanandam, Gupta: "Increased expression of alternatively spliced dominant-negative isoform of SRF in human failing hearts." in: American journal of physiology. Heart and circulatory physiology, Vol. 282, Issue 4, pp. H1521-33, (2002) (PubMed).

Synonyms and alternative names related to SRF

serum response factor (Srf), serum response factor (SRF), serum response factor L homeolog (srf.L), serum response factor a (srfa), AW049942, AW240594, MCM1, RGD1559787, srf, srf-A, srf1, SRFX, XSRF

Protein level used designations for SRF

  • serum response factor
  • DreSrf1
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