Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription (By similarity).
Bainor, Deng, Wang, Lee, Cantor, Logan, David: "Chromatin-Associated Protein SIN3B Prevents Prostate Cancer Progression by Inducing Senescence." in: Cancer research, Vol. 77, Issue 19, pp. 5339-5348, (2017) (PubMed).
Rielland, Cantor, Graveline, Hajdu, Mara, Diaz, Miller, David: "Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression." in: The Journal of clinical investigation, Vol. 124, Issue 5, pp. 2125-35, (2014) (PubMed).
Dhanda, Lindberg, Olsson: "The human SIN3B corepressor forms a nucleolar complex with leukemia-associated ETO homologues." in: BMC molecular biology, Vol. 9, pp. 8, (2008) (PubMed).
Aliases for SIN3B 抗体
SIN3 transcription regulator family member B (sin3b) 抗体 SIN3 transcription regulator family member B (SIN3B) 抗体 SIN3 transcription regulator family member B S homeolog (sin3b.S) 抗体 SIN3 transcription regulator family member B (Sin3b) 抗体 transcriptional regulator, SIN3B (yeast) (Sin3b) 抗体 2810430C10Rik 抗体 fj63d08 抗体 si:dkey-6n6.6 抗体 wu:fj63d08 抗体