SIM1 and SIM2 genes are Drosophila single-minded (sim) gene homologs. The Drosophila sim gene encodes a transcription factor that is a master regulator of fruit fly neurogenesis. SIM2 maps within the so-called Down syndrome chromosomal region. Based on the mapping position, its potential function as transcriptional repressor and similarity to Drosophila sim, it is proposed that SIM2 may contribute to some specific Down syndrome phenotypes [provided by RefSeq, Jul 2008].
Spellman, Ahmed, Dubach, Gardiner: "Expression of trisomic proteins in Down syndrome model systems." in: Gene, Vol. 512, Issue 2, pp. 219-25, (2012) (PubMed).
Zhang, Xu, Cao, Wei, Yang, Uzan, Peng: "Celastrol regulates multiple nuclear transcription factors belonging to HSP90's clients in a dose- and cell type-dependent way." in: Cell stress & chaperones, Vol. 15, Issue 6, pp. 939-46, (2010) (PubMed).
Fei, Wu, Zhou, Wang, Wang, Yin, Wang, Qiu: "[Association study of SIM2 gene polymorphisms with susceptibility to congenital scoliosis in a Chinese Han population]." in: Zhonghua yi xue za zhi, Vol. 89, Issue 41, pp. 2888-93, (2010) (PubMed).