SIGIRR 抗体
(Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
Acts as a negative regulator of the Toll-like and IL-1R receptor signaling pathways. Attenuates the recruitment of receptor-proximal signaling components to the TLR4 receptor, probably through an TIR-TIR domain interaction with TLR4. Through its extracellular domain interferes with the heterodimerization of Il1R1 and IL1RAP (By similarity).
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Latest Publications for our SIGIRR 抗体
: "Toll-like receptors." in: Annual review of immunology, Vol. 21, pp. 335-76, (2003) (PubMed).: "Innate immune recognition." in: Annual review of immunology, Vol. 20, pp. 197-216, (2002) (PubMed).
Aliases for SIGIRR 抗体
single Ig and TIR domain containing (SIGIRR) 抗体single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (Sigirr) 抗体
single immunoglobulin and toll-interleukin 1 receptor (TIR) domain (sigirr) 抗体
single Ig and TIR domain containing (Sigirr) 抗体
AI256711 抗体
RGD1306732 抗体
sc:d148 抗体
TIR8 抗体
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