Use your antibodies-online credentials, if available.
E-cadherin silencing relies on the formation of a complex between the paRNA and microRNA-guided Argonaute 1 (显示 EIF2C1 蛋白) that, together, recruit SUV39H1 (显示 SUV39H1 蛋白) and induce repressive chromatin modifications in the gene promoter
The results show how E-cadherin instructs the assembly of the LGN/NuMA complex at cell-cell contacts, and define a mechanism that couples cell division orientation to intercellular adhesion.
Low CDH1 expression is associated with pancreatic cancer.
the dysregulation of TET2/E-cadherin/beta-catenin (显示 CTNNB1 蛋白) regulatory loop is a critical oncogenic event in HCC (显示 FAM126A 蛋白) progression
At the molecular level, transcription of the adherens junction protein E (显示 CRISP1 蛋白)-cadherin is upregulated on nicotinic acid addition, leading to accumulation of E-cadherin protein at the cell-cell boundary. This can be attributed to nicotinic acid's ability to facilitate the ubiquitination and degradation of Snail1 (显示 SNAI1 蛋白), a transcription factor that represses E-cadherin expression.
down-regulation of USP48 (显示 USP48 蛋白) increases E-cadherin expression and epithelial barrier integrity through reducing TRAF2 (显示 TRAF2 蛋白) stability
AnxA5 (显示 ANXA5 蛋白) 2D-network mediates E-cadherin mobility in the plasmalemma that triggers human trophoblasts aggregation and thereby cell fusion.
The disassociation of the beta-catenin (显示 CTNNB1 蛋白)/E-cadherin complex in the osteoblast membrane under stretch loading and the subsequent translocation of beta-catenin (显示 CTNNB1 蛋白) into the nucleus may be an intrinsic mechanical signal transduction mechanism.
The presence of E-cadherin decreases cortical contractility during mitosis through a signaling cascade leading to multipolar divisions, and its knockout promotes clustering and survival of cells with multiple centrosomes.
E-cadherin expression is not significantly linked to metastatic disease in pancreatic ductal adenocarcinoma.
These results provide the first in vivo evidence that Flotillins regulate E-cadherin-mediated cell-cell junctions to allow epiboly progression.
These collective findings indicate that loss of Bit1 (显示 PTRH2 蛋白) expression contributes to the acquisition of malignant phenotype of human lung epithelial cells via Erk (显示 MAPK1 蛋白) activation-induced suppression of E-cadherin expression.
In zebrafish, E-cadherin is expressed in lens epithelium, whereas N-cadherin (显示 CDH2 蛋白) is required for lens fiber growth
These data indicate that emi1 (显示 FBXO5 蛋白) deficiency-induced defects in vivo are due to the dysregulation of an APC/C-Cdh1 molecular axis.
without Chp (显示 CHP 蛋白) signaling, E-cadh shifts to intracellular vesicles rather than the adhesive contacts needed for directed cell movement during epiboly
Downregulation of E-cadherin gene may cause omphalocele in the Cd chick model by disrupting CRT (显示 CALR 蛋白)-mediated Ca(2 (显示 CA2 蛋白)+) signaling and AJs.
analyzed expression patterns of three zebrafish classical (type I) cadherins (cadherin-1, -2, and -4) in the embryonic zebrafish cranial ganglia and lateral line system
cadherin-1 is detected in the epidermis of the embryonic limb buds and the larval pectoral fins of zebrafish
hab/E-cadherin is necessary for the cell rearrangements that spread the teleost blastoderm over the yolk
Lgl2 (显示 LLGL2 蛋白) and E-cadherin act antagonistically to control the localisation of integrin alpha 6 (显示 ITGA6 蛋白) during the formation of hemidesmosomes in the developing epidermis
E-cadherin/beta-catenin (显示 CTNNB1 蛋白) complex plays an important role in mediating the morphological remodeling of porcine trophoblast cells during placental development.
E-cadherin mRNA/protein were up-regulated in all flutamide-treated corpus luteum of mid- and late pregnancy.
In pig kidney, strong E-cadherin expression was observed in the basolateral plasma membrane of the tubular epithelial cells. E-cadherin immunolabeling was not detected in glomeruli or blood vessels of pig kidney.
Localisation of NANOG (显示 NANOG 蛋白), OCT4 (显示 POU5F1 蛋白), and E-CADHERIN in porcine pre- and peri (显示 PLIN1 蛋白)-implantation embryos.
The epiblast expressed epithelial markers, MUC1 (显示 MUC1 蛋白) and E-CADHERIN, and the pluripotency markers, DNMT3B (显示 DNMT3B 蛋白) and CRIPTO (显示 TDGF1 蛋白).
JNK deficient embryos also have increased intercellular adhesion and defects in e-cadherin localization. Conversely, embryos with overactive JNK have epidermal fragility, increased E-cadherin internalization, and increased membrane localized clathrin.
the switch from E- to N-cadherin (显示 CDH2 蛋白) during epithelial-mesenchymal transition is essential for acquisition of Contact inhibition of locomotion behavior.
Data identify an E-cadherin-dependent mechanical circuit that integrates adhesion, contractile forces and biochemical signaling to drive the polarized organization of junctional tension necessary to build an in vivo epithelial barrier.
E-cadherin expression is reduced in prenatal pancreatic islets of Bmpr1a-deleted mice.
Real-time PCR showed E-cad mRNA decreased in SCC25 while increased in RAW 264.7 of the indirect cell co-culture model, and immunofluoresence (IF) observed the evident switch of E-cad staining from SCC25 to RAW 264.7
Study found that E-cad is crucial for proper morphogenesis and cell movements during gastrulation indicating that a tight spatio-temporal control of cadherin expression is mandatory for morphogenesis independent of their function in tissue sorting.
NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression.
Stretch induced p120 (显示 CTNND1 蛋白) degradation and the endocytosis of E-cadherin, which induced beta-catenin (显示 CTNNB1 蛋白) translocation into the nucleus, a key event in lung injury progress and repair.
IGF-II-mediated loss of E-cadherin is central in developing hepatomegaly in mice and abnormal cell growth in the hepatoma cell line
Overall, hypoxia-induced activation of Twist/miR (显示 MLXIP 蛋白)-214/E-cadherin axis is involved in the EMT (显示 ITK 蛋白) of TECs, and anti-miR (显示 MLXIP 蛋白)-214 may be an attractive strategy to ameliorate the progression of renal fibrosis.
Study shows that over time, epithelial tumor cells undergo epithelial state to a mesenchymal-like state changes (including loss of E-cadherin expression) during primary tumor growth and E-cadherin is re-expressed in metastatic tumor cells.
Neutrophil elastase has the capacity to cleave E-cad and interfere with its cell-cell adhesion function in acutely injured lung epithelium.
Transfection of zygotes with 100 and 200 nM E-cadherin siRNA led to a 72 and 38% reduction, respectively, in E-cadherin mRNA relative abundance in Day 7 blastocysts compared with controls.
E-cadherin and beta-catenin (显示 CTNNB1 蛋白) were distributed not only at the cell to cell boundary but throughout the cytoplasm in binucleate trophoblast cells
Results describe the effect of suppression of connexin 43 (显示 GJA1 蛋白) and E-cadherin on the development, mRNA and protein expression of bovine blastocysts cultured in vitro or in vivo.
This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function is thought to contribute to progression in cancer by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. Identified transcript variants arise from mutation at consensus splice sites.
, cadherin 1, E-cadherin (epithelial)
, calcium-dependent adhesion protein, epithelial
, cell-CAM 120/80
, epithelial cadherin
, hypothetical protein LOC368517
, cadherin 1, epithelial
, half baked
, cadherin 1, type 1, E-cadherin (epithelial)
, liver cell adhesion molecule
, liver cell adhesion protein
, Epithelial cadherin