SET Domain Containing (Lysine Methyltransferase) 8 抗体
(SET Domain Containing (Lysine Methyltransferase) 8 (SETD8))
Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates 'Lys-20' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53/TP53 at 'Lys-382', leading to repress p53/TP53-target genes (By similarity).
| Catalog no. | 产品 | 适用 | 宿主 / 克隆类型 | 应用 | 价格和交货时间 |
|---|---|---|---|---|---|
| SETD8 抗体 (AA 109-272) | 人 | 小鼠 Monoclonal |
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| SETD8 抗体 (AA 109-272) | 人 | 小鼠 Monoclonal |
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| SETD8 抗体 (N-Term) | 人 | 小鼠 Monoclonal |
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| SETD8 抗体 (AA 220-249) | 人 | 兔 Polyclonal |
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| SETD8 抗体 (N-Term) | 人, 小鼠 | 小鼠 Monoclonal |
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| SETD8 抗体 (N-Term) | 人, 小鼠 | 兔 Polyclonal |
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| SETD8 抗体 (AA 73-352) | 人 | 兔 Polyclonal |
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| SETD8 抗体 (N-Term) | 人 | 兔 Polyclonal |
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| SETD8 抗体 | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| SETD8 抗体 (C-Term) | 人 | 兔 Polyclonal |
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| SETD8 抗体 (N-Term) | 人, 小鼠 | 小鼠 Monoclonal |
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| SETD8 抗体 | 人 | 兔 Monoclonal |
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| SETD8 抗体 (Internal Region) | 人, 小鼠, 大鼠 | 兔 Polyclonal |
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| SETD8 抗体 (AA 136-258) | 人 | 兔 Polyclonal |
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| SETD8 抗体 (N-Term) | 人 | 小鼠 Monoclonal |
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| SETD8 抗体 (AA 263-393) | 人 | 兔 Polyclonal |
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| SETD8 抗体 (AA 362-393) | 人 | 兔 Polyclonal |
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| SETD8 抗体 (AA 25-53) | 人, 小鼠 | 兔 Polyclonal |
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| SETD8 抗体 (N-Term) (APC) | 人 | 小鼠 Monoclonal |
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| SETD8 抗体 (AA 362-393) (APC) | 人 | 兔 Polyclonal |
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Primary Antibody
- ELISA (ELISA: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 5E10F7
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- AA 109-272
Primary Antibody
- ELISA (ELISA: 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 7H1G10
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- AA 109-272
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
1 reference - 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 43AT551-86
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- FACS (Flow Cytometry: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB18964
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 220-249
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 43AT551-86
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 有验证图片)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB1415
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 25-53, N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IF (Immunofluorescence: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 73-352
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 克隆
- RB1417
- 标记
- unconjugated
- 抗体亚型
- Ig Fraction
- 抗原表位
- AA 362-393, C-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- 适用
- 人, 小鼠
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- 43AT890
- 标记
- unconjugated
- 抗体亚型
- IgG1
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 有验证图片)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人, 小鼠, 大鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- Internal Region
Primary Antibody
- IHC (Immunohistochemistry: 有验证图片)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 136-258
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 克隆
- G1F8
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗体亚型
- IgG
- 抗原表位
- AA 263-393
Primary Antibody
- WB (Western Blotting: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 362-393
Primary Antibody
- WB (Western Blotting: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- IHC (p) (Immunohistochemistry (Paraffin-embedded Sections): 所列应用)
- 适用
- 人, 小鼠
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- unconjugated
- 抗原表位
- AA 25-53
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- IHC (Immunohistochemistry: 所列应用)
- ICC (Immunocytochemistry: 所列应用)
- 适用
- 人
- 宿主
- 小鼠
- 克隆形成能力
- Monoclonal
- 标记
- APC
- 抗体亚型
- IgG1
- 抗原表位
- N-Term
Primary Antibody
- WB (Western Blotting: 所列应用)
- ELISA (ELISA: 所列应用)
- 适用
- 人
- 宿主
- 兔
- 克隆形成能力
- Polyclonal
- 标记
- APC
- 抗体亚型
- IgG
- 抗原表位
- AA 362-393
Latest Publications for our SET Domain Containing (Lysine Methyltransferase) 8 抗体
: "Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8." in: Biochemistry, Vol. 47, Issue 25, pp. 6671-7, (2010) (PubMed).
: "Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation." in: PLoS ONE, Vol. 2, Issue 8, pp. e763, (2010) (PubMed).
: "An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 19, pp. 6292-300, (2009) (PubMed).
: "Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19478-88, (2008) (PubMed).
: "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin." in: Molecular cell, Vol. 9, Issue 6, pp. 1201-13, (2002) (PubMed).
: "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase." in: Current biology : CB, Vol. 12, Issue 13, pp. 1086-99, (2002) (PubMed).
: "Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation." in: PLoS ONE, Vol. 2, Issue 8, pp. e763, (2010) (PubMed).
: "An miR-502-binding site single-nucleotide polymorphism in the 3'-untranslated region of the SET8 gene is associated with early age of breast cancer onset." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 19, pp. 6292-300, (2009) (PubMed).
: "Catalytic function of the PR-Set7 histone H4 lysine 20 monomethyltransferase is essential for mitotic entry and genomic stability." in: The Journal of biological chemistry, Vol. 283, Issue 28, pp. 19478-88, (2008) (PubMed).
: "PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin." in: Molecular cell, Vol. 9, Issue 6, pp. 1201-13, (2002) (PubMed).
: "Purification and functional characterization of SET8, a nucleosomal histone H4-lysine 20-specific methyltransferase." in: Current biology : CB, Vol. 12, Issue 13, pp. 1086-99, (2002) (PubMed).
Aliases for SET Domain Containing (Lysine Methyltransferase) 8 抗体
lysine methyltransferase 5A (KMT5A) 抗体lysine methyltransferase 5A (Kmt5a) 抗体
lysine methyltransferase 5Ab (kmt5ab) 抗体
lysine methyltransferase 5A S homeolog (kmt5a.S) 抗体
lysine methyltransferase 5Aa (kmt5aa) 抗体
2410195B05Rik 抗体
AA617402 抗体
AW536475 抗体
KMT5A 抗体
kmt5a 抗体
kmt5a-a 抗体
PR-Set7 抗体
PR-SET7 抗体
Pr-set7 抗体
RGD1305893 抗体
SET07 抗体
SET8 抗体
set8a 抗体
Setd8 抗体
setd8 抗体
setd8-a 抗体
setd8a 抗体
setd8b 抗体
wu:fc23f12 抗体
wu:fj33f02 抗体
zgc:153719 抗体
zgc:171649 抗体
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