Separase 抗体
(Extra Spindle Poles Like 1 (ESPL1))
Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21\; MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010].
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93 results :
ESPL1
适用: 人
ELISA, WB, IHC (p)
宿主: 小鼠
Monoclonal
6H6
unconjugated
7 references
ESPL1
适用: 人, 小鼠
ELISA, IHC, WB, IF
宿主: 兔
Polyclonal
unconjugated
ESPL1
适用: 人
IHC (p), DB
宿主: 兔
Polyclonal
RB7943
unconjugated
1 reference
ESPL1
适用: 人, 小鼠
ELISA, IHC, WB, IF
宿主: 兔
Polyclonal
unconjugated
ESPL1
适用: 人
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
宿主: 兔
Polyclonal
unconjugated
ESPL1
适用: 人
ELISA, IF (cc), IF (p), IHC (p), IHC (fro), ICC
宿主: 兔
Polyclonal
unconjugated
ESPL1
适用: 人
IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 680
ESPL1
适用: 人
IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 750
ESPL1
适用: 人
IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 594
ESPL1
适用: 人
IF (cc), IF (p)
宿主: 兔
Polyclonal
AbBy Fluor® 594
Latest Publications for our Separase 抗体
: "MMTV-Espl1 transgenic mice develop aneuploid, estrogen receptor alpha (ER?)-positive mammary adenocarcinomas." in: Oncogene, Vol. 33, Issue 48, pp. 5511-22, (2014) (PubMed).: "Overexpression and constitutive nuclear localization of cohesin protease Separase protein correlates with high incidence of relapse and reduced overall survival in glioblastoma multiforme." in: Journal of neuro-oncology, Vol. 119, Issue 1, pp. 27-35, (2014) (PubMed).
: "Identification and Characterization of Separase Inhibitors (Sepins) for Cancer Therapy." in: Journal of biomolecular screening, Vol. 19, Issue 6, pp. 878-889, (2014) (PubMed).
: "The proteolytic activity of separase in BCR-ABL-positive cells is increased by imatinib." in: PLoS ONE, Vol. 7, Issue 8, pp. e42863, (2012) (PubMed).
: "Separase loss of function cooperates with the loss of p53 in the initiation and progression of T- and B-cell lymphoma, leukemia and aneuploidy in mice." in: PLoS ONE, Vol. 6, Issue 7, pp. e22167, (2011) (PubMed).
: "Calpain-1 cleaves Rad21 to promote sister chromatid separation." in: Molecular and cellular biology, Vol. 31, Issue 21, pp. 4335-47, (2011) (PubMed).
: "Overexpression and mislocalization of the chromosomal segregation protein separase in multiple human cancers." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 15, Issue 8, pp. 2703-10, (2009) (PubMed).
: "Functional interaction between BubR1 and securin in an anaphase-promoting complex/cyclosomeCdc20-independent manner." in: Cancer research, Vol. 69, Issue 1, pp. 27-36, (2009) (PubMed).
: "Separase is recruited to mitotic chromosomes to dissolve sister chromatid cohesion in a DNA-dependent manner." in: Cell, Vol. 137, Issue 1, pp. 123-32, (2009) (PubMed).
: "Regulation of the anaphase-promoting complex-separase cascade by transforming growth factor-beta modulates mitotic progression in bone marrow stromal cells." in: Molecular biology of the cell, Vol. 19, Issue 12, pp. 5446-55, (2008) (PubMed).
Aliases for Separase 抗体
extra spindle pole bodies like 1, separase (ESPL1) 抗体extra spindle poles like 1 (espl1) 抗体
extra spindle pole bodies 1, separase (Espl1) 抗体
extra spindle pole bodies like 1, separase (Espl1) 抗体
AL024103 抗体
AU045071 抗体
Cerp 抗体
ESP1 抗体
mp:zf637-3-001691 抗体
PRCE 抗体
SEPA 抗体
SSE 抗体
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