Separase 抗体 (AA 767-816)
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Quick Overview for Separase 抗体 (AA 767-816) (ABIN1532260)
抗原
See all Separase (ESPL1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 767-816
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原理
- Separase Antibody
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特异性
- Separase Polyclonal Antibody detects endogenous levels of Separase protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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纯度
- > 95 %
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免疫原
- The antiserum was produced against synthesized peptide derived from human SEPARASE. AA range:767-816
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亚型
- IgG
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anti-Extra Spindle Poles Like 1 (ESPL1) (AA 586-701) antibody
ESPL1 适用: 人 WB, IHC (p) 宿主: 小鼠 Monoclonal 6H6 unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (pSer1126) antibodyESPL1 适用: 人 IHC (p), DB 宿主: 兔 Polyclonal RB7943 unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (AA 586-702) antibodyESPL1 适用: 人 ELISA, IHC, WB, IHC (p) 宿主: 小鼠 Monoclonal 6H6 unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) antibodyESPL1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (Tyr489) antibodyESPL1 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (AA 1220-1500) antibodyESPL1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (AA 1292-1495) antibodyESPL1 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) antibodyESPL1 适用: 小鼠 WB 宿主: 山羊 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (pSer801) antibodyESPL1 适用: 人 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Extra Spindle Poles Like 1 (ESPL1) (pSer801) antibodyESPL1 适用: 人, 小鼠 ELISA, IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:40000. Not yet tested in other applications.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 mg/mL
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缓冲液
- Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C/1 year
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有效期
- 12 months
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- Separase (ESPL1) (Extra Spindle Poles Like 1 (ESPL1))
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别名
- SEPARASE
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背景
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Synonyms: ESPL1, ESP1, KIAA0165, Separin, Caspase-like protein ESPL1, Extra spindle poles-like 1 protein, Separase
Background: Stable cohesion between sister chromatids before anaphase and their timely separation during anaphase are critical for chromosome inheritance. In vertebrates, sister chromatid cohesion is released in 2 steps via distinct mechanisms. The first step involves phosphorylation of STAG1 (MIM 604358) or STAG2 (MIM 300826) in the cohesin complex. The second step involves cleavage of the cohesin subunit SCC1 (RAD21, MIM 606462) by ESPL1, or separase, which initiates the final separation of sister chromatids (Sun et al., 2009 [PubMed 19345191]).[supplied by OMIM, Nov 2010],
Gene Name: ESPL1
Protein Name: Separin
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分子量
- 233 kDa
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基因ID
- 9700
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OMIM
- 604143
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UniProt
- Q14674
抗原
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